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Sulfadiazine silver controlled-release gel and preparation method thereof

A technology of silver sulfadiazine and silver controlled-release gel, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve pain, quantification is difficult to accurately control, and the action time is short, etc. problem, to achieve the effect of controlling wound infection, promoting healing, and relieving transient pain

Inactive Publication Date: 2010-10-13
SANITARY EQUIP INST ACAD OF MILITARY MEDICAL SCI PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the deficiencies of the prior art silver sulfadiazine ointment in the treatment of wound infection, such as short action time, pain, and difficult quantitative control, and provide a sulfadiazine that has a good moisturizing effect, is easy to remove, and is also beneficial to wound healing. Silver Controlled Release Gel

Method used

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  • Sulfadiazine silver controlled-release gel and preparation method thereof
  • Sulfadiazine silver controlled-release gel and preparation method thereof
  • Sulfadiazine silver controlled-release gel and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0039] A kind of sulfadiazine silver controlled-release gel is made by following method:

[0040] (1) Under the condition of avoiding light, mix 0.001g of silver sulfadiazine and 20ml of 0.005g / ml sodium alginate aqueous solution to form a suspension, pour it on the glass plate mold, make its natural flow edge smooth, and avoid Under light conditions, freeze at -5°C for 5 hours, thaw at room temperature for 3 hours, and repeat freezing-thawing 5 times;

[0041] (2) get the water-soluble chitosan aqueous solution of 0.01g / ml of 100ml, add the calcium chloride of 1g, fully stir, make it dissolve, make water-soluble chitosan-calcium chloride mixed solution; Step (1 ) prepared product immersed in the water-soluble chitosan-calcium chloride mixed solution, placed for 10min, after removing the glass plate mold, rinsed 3 times with deionized water to obtain the silver sulfadiazine controlled-release gel.

[0042] The extract of the sulfadiazine silver controlled-release gel prepared...

Embodiment 2

[0044] A silver sulfadiazine controlled-release gel is characterized in that it is made by the following method:

[0045] (1) Under dark conditions, mix 0.1g of silver sulfadiazine and 20ml of 0.05g / ml sodium alginate aqueous solution into a suspension, and pour it on the glass plate mold to make its natural flow edge smooth. Under dark conditions, freeze at -20°C for 20 hours, thaw at room temperature for 7 hours, and repeat freezing-thawing 10 times;

[0046] (2) get the water-soluble chitosan aqueous solution of 0.005g / ml of 500ml, add the calcium chloride of 50g, fully stir, make it dissolve, make water-soluble chitosan-calcium chloride mixed solution; Step (1 ) The product prepared was immersed in the water-soluble chitosan-calcium chloride mixed solution, placed for 5min, and after removing the glass plate mold, rinsed 4 times with deionized water to obtain the silver sulfadiazine controlled-release gel.

[0047] The appearance of the silver sulfadiazine controlled-rele...

Embodiment 3

[0049] A silver sulfadiazine controlled-release gel is characterized in that it is made by the following method:

[0050] (1) Under the condition of avoiding light, mix 0.01g of silver sulfadiazine and 20ml of 0.01g / ml sodium alginate aqueous solution to form a suspension, pour it on the glass plate mold, make its natural flow edge smooth, and avoid Under light conditions, freeze at -10°C for 5 hours, thaw at room temperature for 1 hour, and repeat freezing-thawing 4 times;

[0051] (2) get the water-soluble chitosan aqueous solution of 0.05g / ml of 50ml, add the calcium chloride of 0.25g, fully stir, make it dissolve, make water-soluble chitosan-calcium chloride mixed solution; Step ( 1) The prepared product was submerged in the water-soluble chitosan-calcium chloride mixed solution, placed for 60 min, and after the glass plate mold was removed, rinsed 5 times with deionized water to obtain the silver sulfadiazine controlled-release gel.

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Abstract

The invention discloses sulfadiazine silver controlled-release gel which is prepared by the following method: (1) evenly mixing sulfadiazine silver and sodium alginate aqueous solution into a suspension in darkness, pouring the suspension onto a glass plate mold to make same naturally and smoothly flow, freezing and unfreezing at the room temperature in darkness; (2) adding calcium chloride to water-soluble chitosan solution, and fully mixing until the calcium chloride is dissolved to obtain the water-soluble chitosan-calcium chloride mixture; and (3) immersing the prepared product in step (1) in the water-soluble chitosan-calcium chloride mixture, holding, removing the glass plate mold and rinsing to obtain the sulfadiazine silver controlled-release gel. The sulfadiazine silver controlled-release gel of the invention has good biocompatibility and achieves the effects of stopping bleeding and helping healing; and the sulfadiazine silver controlled-release gel achieves good effect of moisture preservation and is favorable for healing the wound surface and easily applied and removed, thus relieving the pain of the sick and wounded caused by secondary wound.

Description

technical field [0001] The invention relates to a controlled-release gel of sulfa drugs and a preparation method thereof. Background technique [0002] When a large area of ​​skin is damaged due to bombing, burns, and ulcers, the wound tissue is exposed and opens the door for bacteria. In addition, skin necrosis and blood plasma exudation provide a good environment for bacteria to multiply, especially in hot and humid environments. There are many types, large numbers, and rapid reproduction. The critical number of infection (105 / g tissue) can be reached 8 hours after injury, which can easily lead to a series of pathophysiological changes in the wounded, making the injury more complicated and serious, thereby increasing the number of infections. Trauma complications, mortality and disability. Thus, the timely selection of appropriate antibiotics is the key to treatment. If oral or intravenous administration is adopted, the medicine takes a long time to pass through the bloo...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/635A61K47/36A61P17/02
Inventor 邢楠田丰杨健何春年刘红刘长军李钒
Owner SANITARY EQUIP INST ACAD OF MILITARY MEDICAL SCI PLA
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