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Method for recovering fumaric acid from tiamulin production mother solution

A technology of tiamulin and fumaric acid, which is applied in chemical instruments and methods, separation/purification of carboxylic acid compounds, water/sludge/sewage treatment, etc., can solve the problem of increasing the production cost of tiamulin. Wastewater treatment load, waste of resources and other issues, to achieve the effect of saving treatment costs, reducing production costs, and high recovery rate

Active Publication Date: 2010-10-06
浙江拜克生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This treatment method not only causes a waste of resources, but also increases the production cost of the product tiamulin, and increases the load of wastewater treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Put 500ml of Taimiao salt mother liquor whose content has been detected in a 1000ml reaction bottle (the content of fumaric acid is 7.1%, the content of tiamiaoline is 5%, remove methanol under the pressure of -0.08Mpa, add 320ml of water and 160ml of butyl acetate , add about 120ml of 40% NaOH to adjust the pH>10, stir for 10min, and let stand to separate layers. The oil layer is recovered and treated separately. The water layer is adjusted to PH at 1-2 with 15% sulfuric acid, stirred for 30min, and filtered after fumaric acid is completely precipitated. Wash the fumaric acid crystals with dilute sulfuric acid, and then dry the crystals to obtain 30 g of fumaric acid with a purity of 98.1% and a yield of 82.6%.

Embodiment 2

[0028] Put 500ml of Taimiao salt mother liquor with detected content in a 1000ml reaction bottle (the content of fumaric acid is 8%, the content of tiamiaoline is 5.5%, remove methanol under the pressure of -0.08Mpa, add 400ml of water and 200mlMIBK, add about 150ml of 40% NaOH to adjust the pH to > 10, stir for 30 minutes, and let stand to separate layers. The oil layer is recovered and treated separately. The water layer is adjusted to a pH of 1-2 with 15% hydrochloric acid, and stirred for 30 minutes. After all the fumaric acid is precipitated, filter and wash with dilute hydrochloric acid Fumaric acid crystals were then dried to obtain 33 g of fumaric acid with a purity of 99.2% and a yield of 81.1%.

Embodiment 3

[0030] Put 500ml of Taimiao salt mother liquor with detected content in a 1000ml reaction bottle (the content of fumaric acid is 6.2%, the content of tiamiaoline is 4.5%, remove methanol under the pressure of -0.08Mpa, add 280ml of water and 350mlMIBK, add about 105ml of 40% NaOH to adjust the pH to > 10, stir for 30 minutes, and let stand to separate layers. The oil layer is recovered and treated separately. The water layer is adjusted to a pH of 1-2 with 15% hydrochloric acid, stirred for 30 minutes, and after fumaric acid is completely precipitated, filter and wash with dilute hydrochloric acid Fumaric acid crystals were then dried to obtain 27g of fumaric acid with a purity of 98.9% and a yield of 86.1%.

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Abstract

The invention belongs to the technical field of industrial sewage treatment, in particular to a method for recovering fumaric acid from liquid wastes containing the fumaric acid or fumarates, which are generated in tiamulin production mother solution. The method comprises the following steps: (1) carrying out decompression desolvation on the mother solution to remove an organic solvent to obtain a desolvation solution; (2) adding water the volume of which is 0.5-2.0 times of the desolvation solution and an organic extracting agent the volume of which is 0.3-1.0 time of the desolvation solution to the desolvation solution, and sufficiently stirring; (3) regulating the pH value of the mixed solution obtained in the step 2 to be greater than 10, evenly stirring and then standing for layering, removing an oil layer and preserving a water layer; and (4) adding acid to the water layer so as to regulate the pH value of the water layer to be 1-2 to separate out the fumaric acid and filtering to obtain the fumaric acid. The fumaric acid has high yield and low cost.

Description

technical field [0001] The invention belongs to the technical field of industrial wastewater treatment, and in particular relates to a method for recovering fumaric acid from liquid waste containing fumaric acid or fumarate produced in tiamulin production mother liquor. Background technique [0002] Tiamulin fumarate is a special antibiotic for veterinary use. It was first developed by the Swiss company Novartis in the 1970s. It has the characteristics of quick-acting, broad-spectrum, antibacterial, anti-asthma, and high safety. It has a strong curative effect on single or combined infections caused by mycoplasma, chlamydia, salmonella, staphylococci, etc. Tiamulin fumarate has become one of the top ten veterinary antibiotics in the world due to its superior curative effect. It is mainly used for acute and chronic respiratory diseases of livestock and poultry. , Actinobacillus pleuropneumonia, ileitis, colitis, edema and other diseases. Tiamulin fumarate has incomparable e...

Claims

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Application Information

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IPC IPC(8): C07C57/15C07C51/42C02F1/58
Inventor 余中宝余炜陈明伟赵祖亮
Owner 浙江拜克生物科技有限公司
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