Preparation method of high-flexibility nuclear magnetic resonance imaging contrast agents based on high molecular nanometer particles

Abstract

The invention relates to a nuclear magnetic resonance imaging contrast agent, in particular to a method of high-flexibility nuclear magnetic resonance imaging contrast agents based on high molecular nanometer particles prepared through fine emulsion polymenrization. The nuclear magnetic resonance imaging contrast agents are prepared from the composition of 1, 4, 7, 10-tetrazo heterocycle dodecane with long-chain alkane and gadolinium (Gd-DOTA for short) or the composition of diethylenetriamine pentaacetic acid and gadolinium (Gd-DTPA for short) for carrying out fine emulsion polymenrization preparation with high molecular monomers. The Gd-DOTA derivatives (Gd-DOTA derivatives for short) with the long-chain alkane and the Gd-DTPA derivatives (Gd- DTPA derivatives for short) with the long-chain alkane respectively have the structures as the first formula and the second formula, wherein the value of n is between 8 and 24.

Description

technical field The invention relates to a nuclear magnetic resonance imaging contrast agent, in particular to a method for preparing a high-sensitivity nuclear magnetic resonance imaging contrast agent based on polymer nanoparticles by miniemulsion polymerization. Background technique Magnetic resonance imaging (MRI) technology has received unprecedented attention and application in the field of modern medical diagnosis. It can provide people with high-quality three-dimensional soft tissue imaging pictures under the condition of avoiding ion radiation. It is the main technology for disease diagnosis in the field of modern medicine. one. The signal intensity obtained by MRI mainly depends on the hydrogen nucleus density and the relaxation rate of water protons at the examination site, and the difference in hydrogen nucleus density and relaxation time between different tissues in the human body, between normal tissues and diseased tissues in the same tissue It is the main ba...

AI Technical Summary

Problems solved by technology

Although these small-molecule MRI contrast agents are stable, low-toxic and have good imaging effects, due to the low relaxation rate, more contrast agents need to be injected each time, which increases some potential safety hazards, and these The excretion speed of contrast agent molecules in the human body is fast, and it is easy to penetrate from blood vessels to the cytoplasm, which is not conducive to blood vessel imaging

Although studies have shown that combining small molecule contrast agents with dendrimers through certain chemical constructions can greatly increase their relaxation rate and prolong their circulation time in blood (J Biol Inorg Chem (2007) 12: 406-420 ), but its application is restricted by the difficulty of synthesizing and purifying dendrimers

It has also been found that small molecule contrast agents with long-chain alkanes exist in a micellar state in a higher concentration of aqueous solution (J Biol Inorg Chem (2002) 7: 757-769), and the contrast agents at this time also have higher However, because micelles cannot exist stably at low concentrations, this directly leads to their inability to be applied clinically

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