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Urushiol compound and medicinal composition thereof, preparation method and application thereof

A compound, urushiol technology, applied in the application field of anti-cancer drugs, can solve the problems of no pharmacological reports on anti-tumor angiogenesis and NF-kappaB inhibitory effect, no tumor cell line inhibitory effect, etc.

Inactive Publication Date: 2010-08-18
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report on the inhibitory effect of phenolic compounds in dried lacquer on various tumor cell lines in the prior art, nor is there any pharmacological report on its anti-tumor angiogenesis and NF-kappaB inhibitory effect

Method used

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  • Urushiol compound and medicinal composition thereof, preparation method and application thereof
  • Urushiol compound and medicinal composition thereof, preparation method and application thereof
  • Urushiol compound and medicinal composition thereof, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation and structural identification of structural formula (I) urushiol compound and derivatives:

[0028] Take 17kg of dry resin dry paint (Toxicodendron vernicifluum) from Rhus verniciflua Stokes, crush it, soak and extract with 80% ethanol for 3 times (15L, 10L, 10L), and then soak the residue once more with acetone (8L) , the extracts were combined and concentrated under reduced pressure to obtain 400 g of extract, which was dispersed with an appropriate amount of water and then extracted three times with an equal amount of ethyl acetate, and the extract was concentrated to obtain 220 g of extract. The ethyl acetate extract was subjected to silica gel column chromatography (column specification: 10.5×60cm; silica gel 200-300 mesh, 2.5kg), chloroform-methanol gradient elution, and thin-layer chromatography as a guide (10% sulfuric acid ethanol for color development, The same below) were combined to obtain components A: 1-11 (chloroform-methanol, 98:2, 3L), B: 12...

Embodiment 2

[0038] The urushiol compound shown in the structural formula (I) and its derivatives are obtained by the method of Example 1, and oil for injection is added according to a conventional method, filtered, potted and sterilized, and can be made into an emulsion for injection.

Embodiment 3

[0039] Example 3: Urushiol and its derivatives are prepared according to the method of Example 1, and various other solid and liquid preparations can be prepared by adding various pharmaceutical excipients according to conventional methods.

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PUM

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Abstract

The invention relates to a medicinal preparation, which is prepared from a phenolic compound (shown in a structural formula I) serving as a main active ingredient and extracted from a traditional Chinese medicament dried lacquer and can be prepared into oral formulations such as tablets, capsules and the like or injections. The oral formulations or injections, which uses the phenolic compound in the dried lacquer as the active ingredient, can be added with other components or auxiliary materials to form a compound preparation; the compound preparation has obvious effects of inhibiting tumor cytotoxin activity and tumor angiogenesis, nuclear transcription factor-kappaB activity and the like; and the compound preparation can be used for curing cancers such as leukemia, liver cancer, lung cancer, esophagus cancer, myeloma, breast cancer, colon cancer, prostatic cancer and the like and has an obvious therapeutic effect.

Description

Technical field: [0001] The invention belongs to the technical field of medicines, and in particular relates to urushiol compounds, pharmaceutical preparations prepared with the urushiol compounds as main active ingredients, and their application in anticancer medicines. Background technique: [0002] Cancer is a serious threat to human health, its incidence has been on the rise in recent years, and the number of people dying of cancer is increasing year by year. The World Health Organization (WHO) has predicted that cancer will become the "first killer" of human beings in the 21st century. Cancer control has become a global issue. One of the priorities of the health strategy. Natural medicines play an important role in health care and drug research. Statistics show that about 80% of antibacterial drugs and 60% of anticancer drugs are directly or indirectly derived from natural products (J Nat Prod, 2003, 66: 1022-1237). It shows that nature has become an important source o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C39/19C07C37/68A61K31/05A61P35/00A61P35/02
Inventor 程永现何江波吕青
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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