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Compound Chinese gall ulcer pellicle and preparation method thereof

A compound gallnut and gallnut technology is applied in the directions of drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., and achieves the effects of low price, good therapeutic effect and wide origin.

Inactive Publication Date: 2011-09-07
中国人民解放军第三五九医院
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AI Technical Summary

Problems solved by technology

The traditional Chinese medicine Galla chinensis is used as the main ingredient, supplemented with other drugs to make sustained-release preparations for the treatment of oral ulcers, which has not been reported yet

Method used

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  • Compound Chinese gall ulcer pellicle and preparation method thereof
  • Compound Chinese gall ulcer pellicle and preparation method thereof

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Experimental program
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Effect test

Embodiment

[0015] Prepare the compound Galla gall ulcer medicine film, through the following steps,

[0016] 1. Preparation of Galla gall freeze-dried powder: 100 grams of Galla gall original drug, knocked open to remove insect scale and impurities, rinsed and dried, crushed and passed through a 28-mesh sieve, added 100ml of deionized water to soak at 4°C for 48 hours, sterile filtered and centrifuged, and taken The clear liquid, the filtrate is the water extract of Chinese gallnut. After freeze-drying, 60 grams of gallnut freeze-dried powder was obtained, which was stored at 4°C.

[0017] 2. Prepare other traditional Chinese medicines: borneol, artificial bezoar.

[0018] 3. Prepare film-forming materials: polyvinyl alcohol PVA, sodium carboxymethyl cellulose CMC-Na, and polycarboxyethylene CP (the ratio is 3:6:1).

[0019] 4. Preparation of slow-release film agent: Add 50g of film-forming material, add appropriate amount of water to soak, heat to dissolve, add 10ml of glycerin, 10g o...

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Abstract

The invention relates to a compound Chinese gall ulcer pellicle and a preparation method thereof, relating to the field of treatment medicines of oral ulcers. The compound Chinese gall ulcer pellicle comprises the following raw materials in parts by weight: 45-55 parts of pellicle-forming materials, 6-8 parts of glycerol, 9-12 parts of Chinese gall freeze-dried powder, 2-3 parts of borneols and 2-3 parts of calculus bovis factitious. The Chinese gall slow-release ulcer pellicle combines the traditional Chinese medicine Chinese gall with a novel clinical formulation-slow-release formulation, solves the problem of medicines for oral cavities and enables the traditional Chinese medicine to have new clinical application; proved by animal tests and clinical tests, the effective components of the Chinese gall have good treatment effect on oral cavity ulcer; the compound Chinese gall slow-release ulcer pellicle prepared by the Chinese gall has convenient use and can keep partial medicine concentration; the components of the compound Chinese gall slow-release ulcer pellicle can fast adhere to an ulcer surface when meeting spittle; a support can slowly release the medicines; in addition, aproblem that the medicines for the oral cavities are easy to wash away by the spittle and has short action time is solved.

Description

technical field [0001] The invention relates to a medicine for treating oral ulcer, in particular to a compound gallica ulcer medicinal film and a preparation method thereof. Background technique [0002] Oral mucosal ulceration is a common clinical symptom in the Department of Stomatology, and it is the clinical manifestation of systemic or local diseases in the oral cavity. The most common diseases that cause oral mucosal ulceration are recurrent oral ulceration, lichen planus, etc. One of the main clinical manifestations of hand, foot and mouth disease, which has become popular in recent years, is herpetic oral mucosal ulceration. [0003] The prevalence rate of recurrent oral ulcer in the population is about 25%. Because its etiology and pathogenesis are unknown, and systemic medication has side effects, the treatment is mostly based on topical medication aimed at its symptoms. [0004] At present, the drugs commonly used in local treatment of oral ulcers include antibi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K35/64A61P1/02A61K31/045A61K35/413
Inventor 张苏娜
Owner 中国人民解放军第三五九医院
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