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Application of radix scutellariae and flavonoid against sub-type infection of influenza virus A (H1N1)

A technology for anti-influenza virus and flavonoids of scutellaria baicalensis, which is applied in the directions of antiviral agents, medical preparations containing active ingredients, and plant raw materials.

Inactive Publication Date: 2010-08-11
曲敬来
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no relevant research or report on the use of baicalin flavones for anti-influenza A new H1N1, influenza A H1N1 and influenza A H3N2

Method used

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  • Application of radix scutellariae and flavonoid against sub-type infection of influenza virus A (H1N1)
  • Application of radix scutellariae and flavonoid against sub-type infection of influenza virus A (H1N1)
  • Application of radix scutellariae and flavonoid against sub-type infection of influenza virus A (H1N1)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The assay of embodiment 1 tested sample

[0035] Test sample: baicalein

[0036] Baicalin

[0037] Scutellaria baicalensis total flavonoids extract 1

[0038] Scutellaria baicalensis total flavonoids extract 2

[0039] Determination method: take appropriate amount of four groups of test samples, weigh them accurately, add methanol to dissolve and dilute to a solution with a concentration of 1.0 μg / mL, filter, take the subsequent filtrate as the test solution; take baicalein, baicalin An appropriate amount of glycoside reference substance was prepared in the same way as a corresponding reference substance solution; the contrast solution and the test solution were measured respectively, and determined according to the HPLC method. The elution gradient is shown in the table below, the flow rate is 1mL / min, the injection volume is 20μL, the detection wavelength is 275nm, and the detection is at room temperature.

[0040] The contents of baicalein and baicalin were calcu...

Embodiment 2

[0044] Example 2 The inhibitory effect of baicalein on influenza A subtype

[0045] According to the in vitro antiviral test method under the content of the invention, the inhibitory effect of baicalein test samples on cytopathic changes caused by influenza A H1N1 and H3N2 subtypes was investigated according to the law, and the results of the investigation are shown in the following table:

[0046] Table 2: Inhibitory effect of baicalein on influenza A H1N1 and H3N2 subtypes

[0047]

Embodiment 3

[0048] Embodiment 3: the inhibitory effect of baicalin on influenza A subtype

[0049] According to the in vitro antiviral test method, the inhibitory effect of baicalin test samples on cytopathic changes caused by influenza A H1N1 and H3N2 subtypes was investigated according to law, and the results of the investigation are shown in the following table:

[0050] Table 3: Inhibitory effect of baicalin on influenza A H1N1 and H3N2 subtype viruses

[0051]

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Abstract

The invention discloses the application of radix scutellariae and flavonoid against sub-type infection of influenza virus A (H1N1), and the application of scutellarein, baicalin and total flavonoid extract of radix scutellaria in preparation of drug against novel influenza A (H1N1), influenza A (H1N1) and H3N2 sub-type of influenza virus and hygienic products. The active substances in the scutellarein, baicalin and total flavonoid extract of radix scutellaria are mixed with an excipient acceptable on pharmaceutics to prepare the preparation and the hygienic products acceptable to patients. The invention is applied to the treatment and the prevention of the novel influenza A (H1N1), influenza A (H1N1) and H3N2 sub-type influenza and has remarkable curative effect and good safety.

Description

technical field [0001] The invention relates to a kind of active substance of baicalin flavonoids which can be used for resisting the subtype infection of influenza A virus, belongs to the technical field of biomedicine, and in particular relates to mixing the active substance of flavonoids with excipients allowed in pharmacy to prepare Patient-acceptable preparations and hygienic articles for the treatment or prevention of new type A H1N1 influenza, type A H1N1 influenza and type A H3N2 influenza. Background technique [0002] Influenza viruses are divided into three types: A, B, and C. The pathogenic strains are mainly types A and B, and type C is basically not pathogenic. Among them, influenza A virus is the main pathogen of several worldwide influenza epidemics, and most of the current epidemics in the world are type A. So far, 15 different hemagglutinins and neuraminidases of influenza A virus have been isolated and identified, which can be divided into various subtype...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/7048A61K36/539A61P31/16
Inventor 曲敬来刘玉玲高雪
Owner 曲敬来
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