Method for controlling quality of Resina Draconis drug

A technology of dragon's blood and medicinal materials, which is applied in the field of quality control of dragon's blood medicinal materials

Active Publication Date: 2010-07-21
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] "National Standards of the State Drug Administration" [WS 3 -082(Z-016)-99(Z)] included detection methods for the properties, TLC identification, and content determination of dracaine B of Dracaena dracaena, and the national standard did not include p-total phenols. and 7,4'-dihydroxyflavone content determination items; in addition, after searching, No. 200510010851.1 patent provides a kind of quality control method for detecting the content of dragon blood A and dragon blood in the medicinal material of dragon's blood, but the method There is also no detection of the content of total phenols and 7,4'-dihydroxyflavones in the medicinal materials of dragon's blood. The assay method of content, but also provides another method for assaying dragon's blood B which is different from the previous method, not only that, the present invention also provides the standard fingerprint spectrum of dragon's blood medicinal material and the application method of the spectrum

Method used

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  • Method for controlling quality of Resina Draconis drug
  • Method for controlling quality of Resina Draconis drug
  • Method for controlling quality of Resina Draconis drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0248] Example 1: Determination method of total phenol content

[0249] a. Source of reference substance: 7,4'-dihydroxyflavone, for content determination, purity 98.23%

[0250] Preparation of reference solution: Take an appropriate amount of 7,4'-dihydroxyflavone, accurately weigh it, place it in a brown measuring flask, add absolute ethanol to make a solution containing 28μg per 1ml, and get it;

[0251] b. Preparation of standard curve: accurately measure 0, 1.0, 1.5, 2.0, 2.5, 3.0ml of reference solution, put them into 25ml measuring flasks, add absolute ethanol to 5ml, add 0.2% dodecyl sulfonic acid Sodium solution 2ml, 0.5% potassium ferricyanide solution 1ml, 0.8% ferric chloride solution 1ml, shake well, place in a dark place for 4 minutes, then add 0.1M hydrochloric acid to the mark, shake well, and protect from light Leave it in place for 30 minutes, with the first copy as blank; according to the UV-Vis spectrophotometry in Appendix VB of the Chinese Pharmacopoeia 2005, t...

Embodiment 2

[0256] Example 2: Determination method of total phenol content

[0257] a. Source of reference substance: 7,4'-dihydroxyflavone, for content determination, purity 98.23%

[0258] Preparation of the reference solution: Take an appropriate amount of 7,4'-dihydroxyflavone, accurately weigh it, place it in a brown measuring flask, add absolute ethanol to make a solution containing 32μg per 1ml, and get it;

[0259] b. Preparation of standard curve: accurately measure the reference solution 0, 1.0, 1.5, 2.0, 2.5, 3.0ml, put them into 25ml measuring flasks, add absolute ethanol to 5ml, add 0.3% dodecyl sulfonic acid 2ml of sodium solution, 1ml of 0.6% potassium ferricyanide solution, 1ml of 0.9% ferric chloride solution, shake well, place in a dark place for 5 minutes, then add 0.1M hydrochloric acid to the mark, shake well, and protect from light Leave it in place for 35 minutes, with the first copy as blank; according to the UV-Vis spectrophotometry in Appendix VB of the Chinese Pharmac...

Embodiment 3

[0264] Example 3: Determination method of total phenol content

[0265] a. Source of reference substance: 7,4'-dihydroxyflavone, for content determination, purity 98.23%

[0266] Preparation of the reference solution: Take an appropriate amount of 7,4'-dihydroxyflavone, accurately weigh it, place it in a brown measuring flask, add absolute ethanol to make a solution containing 35μg per 1ml, and get it;

[0267] b. Preparation of standard curve: accurately measure 0, 1.0, 1.5, 2.0, 2.5, 3.0ml of reference solution, put them into 25ml measuring flasks, add absolute ethanol to 5ml, and add 0.4% dodecyl sulfonic acid 2ml of sodium solution, 1ml of 0.7% potassium ferricyanide solution, 1ml of 1.0% ferric chloride solution, shake well, place in a dark place for 10 minutes, add 0.1M hydrochloric acid to the mark, shake well, and protect from light Place for 40 minutes, with the first copy as blank; according to the UV-Vis spectrophotometry in Appendix VB of the Chinese Pharmacopoeia 2005, ...

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Abstract

The invention provides a method for controlling the quality of Resina Draconis drug. The method can be one or more of the following four methods for controlling the quality: (1) determining the content of total phenols; (2) determining the content of 7,4'-dihydroxyflavone; (3) determining the content of loureirin B; and (4) detecting high performance liquid chromatography fingerprint. The invention provides an accurate and precise method for controlling the quality with good stability, which can effectively control the quality of the Resina Draconis drug.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine analysis, and relates to a quality control method of Chinese medicinal materials, in particular to a quality control method of dragon's blood medicinal materials. technical background [0002] Dragon's blood is a resin obtained by extracting the fat-containing wood of Dranaena cochinchinensis (Lour.) S.C. Chen of Liliaceae. Mainly produced in Guangxi and Yunnan. According to the "Compendium of Materia Medica", it has a warm, calm nature, sweet, salty, non-toxic, enters the blood, and returns to the three meridians of the lung, spleen, and kidneys. Significant effects such as sore muscles. Modern medical research has confirmed that Dragon's Blood can improve the microcirculation of the body, adjust the body's metabolism, and improve the body's immune function. [0003] "National Standards of the State Drug Administration" [WS 3 -082(Z-016)-99(Z)] includes the properties, thin-layer identific...

Claims

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Application Information

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IPC IPC(8): A61K36/889G01N21/33G01N30/36G01N30/86
Inventor 萧伟屠鹏飞王振中刘涛徐玉玲毕宇安邹艳萍章晨峰吴云孙永城
Owner JIANGSU KANION PHARMA CO LTD
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