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Antibacterial functionalized artificial joint with silver-loaded nanotube array surface

A nanotube array, artificial joint technology, applied in inorganic chemistry, titanium compounds, chemical instruments and methods, etc., can solve the problem of not involving the surface preparation of metal substrates, and achieve the effect of not easy to produce drug resistance and high sterilization efficiency

Inactive Publication Date: 2010-07-07
江苏广达医材集团有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this preparation method can only prepare dispersed titanate structures, and does not involve the preparation of the surface of the metal substrate

Method used

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  • Antibacterial functionalized artificial joint with silver-loaded nanotube array surface
  • Antibacterial functionalized artificial joint with silver-loaded nanotube array surface
  • Antibacterial functionalized artificial joint with silver-loaded nanotube array surface

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) First choose titanium alloy to process the artificial joint;

[0029] (2) Artificial joint surface pretreatment: After the surface is polished, wash it with acetone, deionized water and absolute ethanol in sequence for 10-30 minutes, and then wash it with HF and HNO 3 and water (volume ratio: 1:4:5) chemically polish for 20-40 seconds, rinse thoroughly with deionized water, and dry for use;

[0030] (3) Preparation of aqueous organic electrolyte solution: using ethylene glycol as a solvent, other active ingredients are: water 2vol% (volume percent), phosphoric acid 4vol% (volume percent), ammonium fluoride 0.3wt% (mass percent);

[0031](4) Preparation of titanium dioxide nanotubes by two-step anodization: the surface pretreated artificial joint is used as the anode, graphite or platinum sheet is used as the cathode, and the first anodization is carried out in an aqueous organic electrolyte solution. The specific anodization parameters are: voltage 60V, the reactio...

Embodiment 2

[0036] (1) First choose titanium to process the artificial joint;

[0037] (2) Artificial joint surface pretreatment: After the surface is polished, wash it with acetone, deionized water and absolute ethanol in sequence for 30-60 minutes, and then wash it with HF and HNO 3 and water (volume ratio: 1:4:5) chemically polish for 40-60 seconds, then rinse thoroughly with deionized water, and blow dry with a hair dryer for use;

[0038] (3) Preparation of aqueous organic electrolyte solution: using ethylene glycol as a solvent, other active ingredients are: water 2vol% (volume percent), phosphoric acid 4vol% (volume percent), ammonium fluoride 0.5wt% (mass percent);

[0039] (4) Preparation of titanium dioxide nanotubes by two-step anodization: the surface pretreated artificial joint is used as the anode, graphite is used as the cathode, and the first anodization is carried out in an aqueous organic electrolyte solution. The specific anodization parameters are: voltage 80V, reactio...

Embodiment 3

[0044] (1) First choose titanium alloy to process the artificial joint;

[0045] (2) Artificial joint surface pretreatment: after surface polishing, wash with acetone, deionized water and absolute ethanol in sequence for 60-90 minutes, and then wash with HF and HNO 3 and water (volume ratio: 1:4:5) chemically polish for 60-80 seconds, then rinse thoroughly with deionized water, and blow dry with a hair dryer for use;

[0046] (3) Preparation of aqueous organic electrolyte solution: using ethylene glycol as a solvent, other active ingredients are: water 4vol% (volume percent), phosphoric acid 6vol% (volume percent), ammonium fluoride 0.5wt% (mass percent);

[0047] (4) Preparation of titanium dioxide nanotubes by two-step anodization: the surface pretreated artificial joint is used as the anode, graphite or platinum sheet is used as the cathode, and the first anodization is carried out in an aqueous organic electrolyte solution. The specific anodization parameters are: voltage ...

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Abstract

The invention relates to an antibacterial functionalized artificial joint with a silver-loaded nanotube array surface. The surface of a metal substrate of the artificial joint is provided with a silver-doped sodium titanate nanotube array layer with a tubular structure. The inside of the silver-doped sodium titanate nanotube array layer is further loaded with bone morphogenetic protein (BMP). A preparation method of the antibacterial functionalized artificial joint with the silver-loaded nanotube array surface comprises the following steps: firstly selecting pure titanium or titanium alloy to process the artificial joint; then adopting the two-step anodizing technology to obtain a titanium dioxide nanotube array layer with a tubular structure on the surface of the pure titanium or titanium alloy artificial joint; adopting the alkaline hydrothermal synthesis technology to convert the titanium dioxide nanotube array layer into the sodium titanate nanotube array layer; doping trace silver in the sodium titanate nanotube array layer by solution impregnation iron exchange; and finally adopting the centrifugal load technology to load the bone morphogenetic protein in the silver-doped sodium titanate nanotube array layer.

Description

technical field [0001] The invention relates to an artificial joint with antibacterial and functionalized surface of silver-loaded nanotube arrays, in particular to an artificial joint with silver-doped sodium titanate nanotubes loaded with bone morphogenetic protein (BMP) on the surface and a preparation method thereof, belonging to Technical field of artificial joint materials. Background technique [0002] Every year, about 1.5 million patients with joint loss due to degenerative and inflammatory arthritis need artificial joint replacement. Among them, the application of metal materials in the manufacture of artificial joints is the earliest, and it is still the most widely used in clinical practice. Over time and clinical studies have shown that artificial joints made of metal materials commonly loosen, sink or break, causing bone resorption, which is one of the main complications affecting the long-term efficacy of artificial joint replacement. Modification of implant...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/06A61L27/56A61L27/54C25D11/26C01G23/00
Inventor 储成林盛晓波
Owner 江苏广达医材集团有限公司
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