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Pharmaceutical composition and preparation method thereof

A composition and drug technology, applied in the field of biomedicine, can solve the problems of not obtaining effective parts of medicinal materials, increasing drug side effects, oxidation of salvianolic acid, etc., and achieving the effects of improving bioavailability, improving curative effect and stable quality

Active Publication Date: 2010-06-23
广州威斯宝药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese Patent Application No. 02149700.1 discloses the oral preparation of Fufang Xueshuantong and its preparation method. The method is to obtain the extract by ultrasonically extracting Panax notoginseng with ethanol, and heat the rest of the Sanqi to obtain the extract by heating and refluxing with ethanol, and then the two extracts After mixing evenly, make a suitable oral dosage form with an appropriate amount of pharmaceutical excipients; none of the above methods uses nitrogen protection when extracting Salvia miltiorrhiza, which can easily lead to oxidation of salvianolic acid, resulting in a decrease in active ingredients
Moreover, these methods are all to make preparations directly from the extract and auxiliary materials, without obtaining the effective parts of the medicinal materials, which reduces the curative effect and increases the side effects of the drug.

Method used

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  • Pharmaceutical composition and preparation method thereof
  • Pharmaceutical composition and preparation method thereof
  • Pharmaceutical composition and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Extraction of effective parts of Compound Xueshuantong of the present invention and preparation of compositions

[0034] Grind 2000g of Panax notoginseng, 640g of Radix Astragali, 640g of Scrophulariae Scrophulariae, and 400g of Salvia miltiorrhiza, and pass through a 12-mesh sieve. After mixing the first three herbs, heat and reflux them with 25L and 20L of 75% ethanol to extract twice, the first time for 2 hours, For the second 1 hour, combine the filtrates; recover the ethanol until there is no alcohol smell, add water to precipitate, let stand overnight, filter, and concentrate the filtrate to a crude drug content of 1 g / ml.

[0035] The extract was passed through a macroporous resin chromatography column ( 10*100), first elute with 20L of water until there is no molish reaction, stop the elution, discard the eluate, and then elute with 15L of 20% ethanol, the eluate mainly contains flavonoid extract, concentrate , spray drying to obtain 32g of total fla...

Embodiment 2

[0038] Example 2 Extraction of effective parts of Compound Xueshuantong of the present invention and preparation of its composition

[0039] (1) Grind 2000g of Panax notoginseng, 640g of Astragalus membranaceus, 640g of Radix Scrophulariae, 400g of Salvia miltiorrhiza, and pass through a 12-mesh sieve. After mixing the medicinal materials of Panax notoginseng, Astragalus membranaceus, and Scrophulariae scrophulariae, mix them with 70% ethanol with 8 times and 6 times the amount respectively Heat and reflux for extraction twice, and combine the filtrate; recover ethanol until it has no alcohol smell, add water to precipitate, let it stand overnight, filter, and concentrate the filtrate to a crude drug content of 1g / ml;

[0040] (2) Pass the extract through the macroporous resin, elute with water first, wash with water until there is no molish reaction, stop the elution, discard the eluent, and then elute with 20% ethanol, the eluent obtained mainly contains flavonoids The extra...

Embodiment 3

[0044] Example 3 Extraction of effective parts of Compound Xueshuantong of the present invention and preparation of its composition

[0045] (1) Grind 2000g of Panax notoginseng, 640g of Astragalus membranaceus, 640g of Radix Scrophulariae, 400g of Salvia miltiorrhiza, and pass through a 12-mesh sieve. After mixing the medicinal materials of Panax notoginseng, Astragalus, and Radix Scrophulariae, mix them with 8 times and 6 times the amount of 95% ethanol respectively Heat and reflux for extraction twice, and combine the filtrate; recover ethanol until it has no alcohol smell, add water to precipitate, let it stand overnight, filter, and concentrate the filtrate to a crude drug content of 1g / ml;

[0046] (2) Pass the extract through the macroporous resin, elute with water first, wash with water until there is no molish reaction, stop the elution, discard the eluent, and then elute with 20% ethanol, the eluent obtained mainly contains flavonoids The extract is concentrated, spr...

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Abstract

The invention provides a pharmaceutical composition and preparation method and application thereof in curing cardio-cerebrovascular diseases. The invention adopts the scheme that the pharmaceutical composition is prepared by taking 25 parts of pseudo-ginseng, 8 parts of Astragalus mongholicus, 8 parts of radix scrophulariae and 5 parts of roots of red-rooted salvia as materials, and the weight ratio of the total flavonoids extracts, the total saponin extracts and the total polyphenolic acid extracts extracted from the four Chinese medicinal herbs is 1-5:1-5:1, wherein the total flavone accounts for more than 80% of the total flavonoids extracts, the total saponin accounts for more than 70% of the total saponin extracts, the total polyphenolic acid accounts form more than 85% of the total polyphenolic acid extracts, and the total content of the flavone, saponin and polyphenol is more than 80%.

Description

technical field [0001] The invention provides a pharmaceutical composition, its preparation method and its application in cardiovascular and cerebrovascular diseases, belonging to the technical field of biomedicine. Background technique [0002] Fufang Xueshuantong is a medicine made from three medicinal materials, Radix Notoginseng, Radix Astragali, Salvia Miltiorrhiza and Scrophulariae Scrophulariae, which are extracted to obtain extracts, and then mixed with medicinal excipients. . It is used to treat retinal vein occlusion with blood stasis and qi and yin deficiency syndrome, such as vision loss or visual abnormality, fundus blood stasis, mental fatigue, dry throat, dry mouth and other symptoms. The active ingredients of Panax notoginseng are mainly Panax notoginseng saponins, the main functions are promoting blood circulation and removing blood stasis, dredging channels and collaterals, dilating blood vessels, improving blood, inhibiting platelet aggregation, increasin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/808A61K9/00A61P27/02A61P9/10A61P3/10
Inventor 刘军杨春玮
Owner 广州威斯宝药业有限公司
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