Nanometer biological robot and application thereof

Abstract

The present invention relates to a nanometer biological robot. The nanometer robot is driven by molecular motors and guided by thrombus antibodies to assist in quickly dissolving thrombi. The rapid rotation of the molecular motors on partial thrombi produces the effect similar to that of a micro power agitator. The molecular motors are driven by light, so the nanometer biological robot is adjustable and controllable. The contact of drugs with fiber proteins is accelerated, the biological and machinery mechanics effect of the nanometer biological robot is synergetic with the medical enzymolysis, and the fibrinolysis is accelerated.

Description

technical field [0001] The invention belongs to the field of nano-biological new technology, and relates to the design, assembly and application of a light-driven nano-robot constructed by a rotary ATP motor and in assisting drug diffusion (thrombolysis). Background technique [0002] Traditional thrombolytic therapy methods include drug thrombolysis and device-assisted thrombolysis. In the rescue treatment of acute myocardial infarction, thrombolytic therapy is an effective method to quickly restore myocardial blood flow, and early use of thrombolytic therapy can reduce the mortality rate of patients with acute myocardial infarction by 30% [FEBS.Lett.2005, 579 (15 ): 3303-3309]. Recombinant tissue plasminogen activator (rt-PA) is currently the most effective thrombolytic drug. The main advantage of this drug is that it has a high affinity with fibrin and fast thrombolytic speed; the disadvantage is that it is easily cleared by the liver. , short half-life (4 minutes to 5 ...

AI Technical Summary

Problems solved by technology

However, due to the inherent limitations of traditional processing technology in terms of device size, there are technical obstacles that are difficult to break through in terms of the design principle, size, and dynamic characteristics of the configurable device at the front end of the guide wire. The application range of interventional therapy is limited to For relatively large blood vessels, the technology itself has some limitations. For example, a large number of thrombus fragments will be generated during the process of mechanical thrombus fragmentation, and their scattering in the blood vessel may cause embolism of small blood vessels in other parts. Corresponding measures for suction thrombus, but the actual needs to be further improved; and in the treatment process of vascular intima rotary cutting and rotary atherectomy device, may cause damage to the vascular intima, resulting in in situ re-formation of thrombus, which limits the technology Further clinical applications

Images