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Method for preparing light sensitive type water soluble chitosan derivative

A technology for water-soluble chitosan and derivatives, which is applied in the field of preparation of photosensitive water-soluble chitosan derivatives, can solve the problems of troublesome post-processing, difficult to control, not conforming to the concept of environmental protection, etc.

Inactive Publication Date: 2011-08-31
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The above methods have the following disadvantages: 1. The post-processing of the preparation method is troublesome and increases the cost; 2. The use of organic solvents introduces toxic substances and reduces the chitosan The biomedical application value of sugar derivatives; 3. The reaction conditions are severe and harsh, and it is not easy to control; 4. The preparation process consumes a lot of energy, and the post-processing causes secondary pollution, which does not conform to the concept of environmental protection

Method used

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  • Method for preparing light sensitive type water soluble chitosan derivative
  • Method for preparing light sensitive type water soluble chitosan derivative
  • Method for preparing light sensitive type water soluble chitosan derivative

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Chitosan (degree of deacetylation DP=90%, weight average molecular weight Mw=500,000) was added in the dilute solution of 2wt% acetic acid, stirred at room temperature for 0.5 hour, and it was prepared as 2% chitosan aqueous solution by weight percentage; Add the N-p-hydroxyphenylacrylamide monomer into ethanol, stir at room temperature for 0.5 hours, and prepare the ethanol solution of N-p-hydroxyphenylacrylamide, wherein the molar number of N-p-hydroxyphenylacrylamide Be 1 times of amino molar number on the chitosan; The chitosan aqueous solution that is 2% by weight and the ethanol solution of photosensitive acrylamide type monomer are mixed to obtain mixed solution; P-hydroxyanisole (its add-on is 1% of the number of moles of photosensitive acrylamide monomer) was added to the above mixed solution, and the stirring was continued at room temperature for 0.5 hours; to 50 mL, purified and vacuum-dried to obtain a photosensitive water-soluble chitosan derivative with a ...

Embodiment 2

[0036] Chitosan (degree of deacetylation DP=70%, weight average molecular weight Mw=200,000) was added in the dilute solution of 2wt% acetic acid, stirred at room temperature for 0.5 hour, and it was prepared as a 2% chitosan aqueous solution by weight percentage; Add the N-p-hydroxyphenylacrylamide monomer into ethanol, stir at room temperature for 0.5 hours, and prepare the ethanol solution of N-p-hydroxyphenylacrylamide, wherein the molar number of N-p-hydroxyphenylacrylamide Be 3 times of amino molar number on the chitosan; Be the chitosan aqueous solution of 2% by weight and the ethanol solution of photosensitive acrylamide type monomer and mix to obtain mixed solution; P-hydroxyanisole (its add-on is 3% of the moles of photosensitive acrylamide monomers) was added to the above mixed solution, and the stirring was continued for 0.5 hours at room temperature; to 50 mL, purified and vacuum-dried to obtain a photosensitive water-soluble chitosan derivative with a degree of s...

Embodiment 3

[0041]Chitosan (degree of deacetylation DP=50%, weight average molecular weight Mw=1,000,000) was added in 2wt% dilute acetic acid solution, stirred at room temperature for 0.5 hour, and prepared into a 2% aqueous solution of chitosan by weight; Add the N-p-hydroxyphenylacrylamide monomer into ethanol, stir at room temperature for 0.5 hours, and prepare the ethanol solution of N-p-hydroxyphenylacrylamide, wherein the molar number of N-p-hydroxyphenylacrylamide Be 4 times of the molar number of amino groups on the chitosan; Mix the ethanol solution that is the chitosan aqueous solution of 2% and the photosensitive acrylamide type monomer by weight percentage to obtain mixed solution; P-hydroxyanisole (its add-on is 4% of the moles of photosensitive acrylamide monomers) was added to the above mixed solution, and the stirring was continued for 0.5 hours at room temperature; to 50 mL, purified and vacuum-dried to obtain a photosensitive water-soluble chitosan derivative with a sub...

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Abstract

The invention relates to a method for preparing a light sensitive type water soluble chitosan derivative. The method comprises the following steps of: adding chitosan into 2-weight percent dilute solution of acetic acid to prepare 2 weight percent aqueous solution of chitosan; adding a light sensitive acrylamide-type monomer of N-p-hydroxyphenyl acrylamide or N-[4-(sulfonamide)phenyl]acryloyl into ethanol to prepare ethanol solution of the light sensitive acrylamide-type monomer; mixing the2 weight percent aqueous solution of chitosan, and the ethanol solution of the light sensitive acrylamide-type monomer to obtain mixed solution; adding p-hydroxyanisole in to the mixed solution; heating the mixed solution to the temperature of between 50 and 70 DEG C for reaction, neutralizing the mixedsolution by using sodium hydroxide and performing rotary evaporation, purifying and vacuum-drying to obtain the light sensitive type water soluble chitosan derivative. The method has the advantages of mild reaction conditions, easy control, simple steps, easily-controllable substitution degree, environmentally-friendly subsequent treatment and economical reaction process.

Description

technical field [0001] The invention relates to a preparation method of photosensitive water-soluble chitosan derivatives. Background technique [0002] Chitin is the structural material of the crustacean shell, and it is the second largest natural biopolymer in the storage capacity that is second only to cellulose in nature. Chitosan is the product of chitin after deacetylation treatment. The natural alkaline polysaccharide existing in the polysaccharide is an amorphous translucent substance, which is non-toxic, harmless, easy to biodegrade, does not pollute the environment, and has good adsorption, hygroscopicity, and film-forming properties. An environment-friendly natural polymer is an inexhaustible renewable resource. Therefore, chitosan has great application value in food, cosmetics, environmental protection, textile, printing and dyeing, papermaking and other industries, especially in the fields of biopharmaceuticals and biological tissue engineering materials. [0...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08
Inventor 马贵平聂俊刘建伟
Owner BEIJING UNIV OF CHEM TECH
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