Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for extracting phillyrin from forsythia

The technology of a forsythin and a new method, which is applied in the new process field of extracting forsythin, can solve the problems of poor product stability, high production cost, complicated process and the like, and achieves good stability, low production cost and low equipment investment. Effect

Inactive Publication Date: 2010-06-16
HEILONGJIANG UNIV
View PDF0 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the present invention, microwaves are used for the extraction of forsythin, the active ingredient of the traditional Chinese medicine Forsythia, compared with the traditional decocting process, the process is more cumbersome, time-consuming, energy-consuming, low in yield, and poor in product stability. Defects such as high production costs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Get 100g of forsythia medicinal material, grind to 16 orders, add 58% ethanol solution to 1000ml soak, add 0.3 gram of sodium lauryl sulfate (K 12 ), heated by microwave for 20 minutes and left to stand for filtration, the residue was added to 1000ml of ethanol solution to soak again, microwave heated for 20 minutes and then left to filter, the combined filtrate was evaporated to solvent on a rotary evaporator, added a small amount of methanol to dissolve, added Mix well with neutral alumina and evaporate to dryness. Operate according to the Pharmacopoeia method, put it on the treated neutral alumina column, elute, evaporate to dryness, and obtain forsythin powder. The high-performance liquid chromatography was used for analysis, and the content was determined by the external standard method, and the extraction rate was calculated according to the content of forsythin in the original medicinal material, and the result was that the extraction rate was 61%.

Embodiment 2

[0022] Take 100g of forsythia medicinal material, crush it to 16 mesh, add 58% ethanol solution to 1500ml for soaking, add 1 gram of sodium dodecylbenzenesulfonate (LAS), heat with 2450MHz, 240W microwave for 20 minutes, then let stand and filter , add 58% ethanol solution to the residue again to soak in 1500ml, heat at 2450MHz, 240W microwave for 20 minutes, then let it stand and filter, combine the filtrate to evaporate the solvent on a rotary evaporator, add a small amount of methanol to dissolve, add neutral alumina and mix well , evaporated to dryness. Operate according to the Pharmacopoeia method, put it on the treated neutral alumina column, elute, evaporate to dryness, and obtain forsythin powder. The high-performance liquid chromatography was used for analysis, and the content was determined by the external standard method, and the extraction rate was calculated according to the content of forsythin in the original medicinal material, and the result was that the extra...

Embodiment 3

[0024] Get 100g of forsythia medicinal material, crush to 16 mesh, add 58% ethanol solution to 2000ml soak, add 3 grams of cetyltrimethylammonium chloride (1631), use 2450MHz, microwave heating of 240W after 20 minutes static Place and filter, add 58% ethanol solution to the residue again to soak in 2000ml, heat at 2450MHz, 240W microwave for 20 minutes, then stand and filter, combine the filtrate to evaporate the solvent on a rotary evaporator, add a small amount of methanol to dissolve, and add neutral alumina Mix well and evaporate to dryness. Operate according to the Pharmacopoeia method, put it on the treated neutral alumina column, elute, evaporate to dryness, and obtain forsythin powder. The high-performance liquid chromatography was used for analysis, the content was determined by the external standard method, and the extraction rate was calculated according to the content of forsythin in the original medicinal material, and the result was that the extraction rate was ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a method for extracting phillyrin from forsythia, which relates to a novel method for extracting phillyrin by the steps of soaking with ethyl alcohol solution, adding surfactant and heating by microwaves. The traditional product generally has the defects of low yield rate, poor stability, high production cost and the like. The method comprises the following steps of: crushing forsythia into 16 meshes; adding 58% ethyl alcohol solution for soaking; adding surfactant which accounts for 0.03-0.3% of the weight of the mixture; heating by microwaves, standing and filtering; adding 58% ethyl alcohol solution into residues for soaking; heating by microwaves, standing and filtering; combining filter liquors, evaporating solvent by using a rotary evaporator, adding a small amount of methyl alcohol solution, adding alumina and uniformly stirring, and evaporating. The operations are performed on the basis of official method, the phillyrin is put on a treated neutral alumina column to elute and evaporate, and then the phillyrin powder is prepared. The invention is used for extracting phillyrin.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a new process for extracting forsythin. Background technique: [0002] The traditional extraction methods mainly include: water decoction, percolation, water boiling-alcohol precipitation extraction, etc. In the process of traditional Chinese medicine preparation, microwave, as a new energy source, has the characteristics of strong penetration, fast heating and uniform heating. In the present invention, microwaves are used for the extraction of forsythin, the active ingredient of the traditional Chinese medicine Forsythia, compared with the traditional decoction process, the process is more cumbersome, time-consuming, energy-consuming, low in yield, and poor in product stability. Defects such as high production costs. Invention content: [0003] The purpose of the present invention is to overcome the deficiencies of the prior art...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/26C07H1/08A61K36/634
Inventor 王阳柏晓辉张宇
Owner HEILONGJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com