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Three-section simulated moving bed chromatography device

A technology for simulating a moving bed and a chromatographic device, which is applied in the field of chromatographic separation devices, can solve the problems of decreased product purity, inability to perform steady-state operation, and decreased separation efficiency, and achieve the effect of improving the effect.

Inactive Publication Date: 2010-06-16
UNIV OF SCI & TECH LIAONING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the extract from band I is difficult to elute, the stationary phase of the column with band I cannot be fully regenerated, and the stationary phase carries the extract into band III, which is equivalent to "tail-catch" between the raffinate and the extract, and a vicious cycle, the system cannot be stabilized State operation, resulting in a decrease in product purity and a decrease in separation efficiency

Method used

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  • Three-section simulated moving bed chromatography device
  • Three-section simulated moving bed chromatography device
  • Three-section simulated moving bed chromatography device

Examples

Experimental program
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Effect test

Embodiment 2

[0041] Such as Figure 2-b As shown, a pump 1 is a three-band simulated moving bed device with 8 chromatographic columns of a gradient pump, the pump 1 is a binary gradient pump, and the liquid storage tank CP of solution A A and solution B reservoir CP B Connect, other structures are with embodiment 1.

Embodiment 3

[0043] Such as Figure 2-c As shown, a three-band simulated moving bed chromatographic device with pump 1 connected to a liquid storage tank CP is equipped with 8 chromatographic columns with their own temperature control boxes, and the 8 chromatographic columns are equipped with their own temperature control boxes H 1 -H 8 , other structures are the same as embodiment 1.

[0044] Three-band simulated moving bed chromatographic device embodiment 4

[0045] Such as Figure 2-d As shown, a kind of pump 1 is a diagram of a three-band simulated moving bed chromatographic device equipped with 8 chromatographic columns of their respective temperature control boxes, and the 8 chromatographic columns are equipped with their respective temperature control boxes H 1 -H 8 , other structures are the same as embodiment 2.

Embodiment 5

[0047] Such as Figure 2-e As shown, a pump 1 is equipped with a filter, an online degasser, a flowmeter on the circulation pipeline, a flowmeter on the total output pipeline, and a solution concentration and purity detector on the total input pipeline connected to a liquid storage tank CP Three-band simulated moving bed setup with 8 columns. The liquid storage tank CP is connected to the pump 1 through the online degasser DG1, and the pump 1 is connected to the eluent P input main pipeline LP through the filter F1; the liquid storage tank CD is connected to the pump 2 through the online degasser DG2, and the pump 2 The filter F2 is connected to the eluent D input main pipeline LD; the liquid storage tank CF is connected to the pump 3 through the online degasser DG3, and the pump 3 is connected to the raw material liquid F input main pipeline LF through the filter F3. The above three online degassers The air machine can also be replaced by a three-channel online degasser; a f...

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Abstract

The invention discloses a three-section simulated moving bed chromatography device comprising N chromatographic columns, two eluent transfer pumps, a feeding liquid transfer pump, 6N automatic control valves, a PLC (programmable logic controller) or SCM (single-chip microcomputer) automatic control system, multi-passes, pipelines and liquid storage tanks, wherein N is not less than 3 and is not more than 24. The mobile phase inlet of each chromatographic column is divided into four paths by the multi-pass Ii; eluents P and D, raw material liquid F and circulating liquid of the previous chromatographic column are introduced and controlled by automatic control valves Pi, Di, Fi and Ti-1; the first chromatographic column is connected with the Nth chromatographic column through the automatic control valve TN from end to end; the mobile phase outlet of each chromatographic column is divided into three paths by the multi-pass Oi; and raffinate R, extract E and circulating liquid of the current chromatographic column are output and controlled by automatic control valves Ri, Ei and Ti so that a three-section simulated moving bed chromatography operation mode with a separate I section or a three-section simulated moving bed chromatography operation mode with back flow between sections I and II is formed. The device has the advantages of simple structure, reliability, flexible and convenient use, low cost, stable operation and high separation efficiency.

Description

technical field [0001] The invention relates to a chromatographic separation device, in particular to a three-band simulated moving bed chromatographic device. Background technique [0002] In the 1960s, UOP Inc. realized the industrial operation of Simulated Moving Bed (SMB) in petrochemical field. Since the 1990s, simulated moving bed technology has been introduced into the pharmaceutical industry, and it has become a research hotspot for the separation of chiral drugs and the separation of biological products. [0003] The simulated moving bed chromatography device is composed of several chromatographic columns connected end to end to form a circulation loop. By moving the positions of the inlet and outlet in an orderly manner along the flow direction of the mobile phase, the relative countercurrent flow of the stationary phase and the mobile phase is simulated, thereby achieving different Separation of components. The system combines chromatographic technology with sim...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D15/18
Inventor 王绍艳林炳昌张伟丛景香唐晓丹兰绍鹏
Owner UNIV OF SCI & TECH LIAONING
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