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Method for synthesizing polysantalol

A technology of polysantalol and synthesis method, applied in chemical instruments and methods, preparation of hydroxyl compounds, preparation of organic compounds, etc., can solve the problems of low reaction yield and complicated operation, achieve high activity and improve reaction yield , Easy to operate effect

Inactive Publication Date: 2010-06-09
SHANGHAI APPLIED TECHNOLOGIES COLLEGE
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  • Description
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Problems solved by technology

The current synthetic method of polysantalol is complex in operation and low in reaction yield

Method used

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  • Method for synthesizing polysantalol

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Embodiment Construction

[0007] The present invention is further illustrated below by way of examples.

[0008] Synthesis of Polysantalol: In the first step, 3-methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl) is obtained by condensation reaction of bornene aldehyde and butanone -3-penten-2-one; second step, 3-methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-3-penten-2- Addition reaction of ketone with methyl iodide to produce 3,3-dimethyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-4-pentene-2- Ketone; the third step, 3,3-dimethyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-4-penten-2-ketone reduction makes poly Sandalol. Its reaction formula is as follows:

[0009]

[0010] a: potassium hydroxide, methanol-water, room temperature, sulfuric acid; b: sodium hydroxide, octadecyltrimethylammonium bromide, toluene, methyl iodide; c: potassium borohydride, ethanol.

[0011] Concrete preparation steps of the present invention:

[0012] The first step: the preparation of 3-methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-y...

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Abstract

The invention discloses a method for synthesizing polysantalol. The method is divided into the following three steps: 1, condensing brain olefine aldehyde and butanone by adopting potassium hydroxide as a catalyst and aqueous solution of methanol as solvent to prepare 3-methyl-5-(2,2,3-trimethyl-3-cyclopentene-1-base)-3-pentene-2-ketone; 2, subjecting the 3-methyl-5-(2,2,3-trimethyl-3-cyclopentene-1-base)-3-pentene-2-ketone and methyl iodide to addition reaction by adopting octadecyl trimethyl ammonium bromide as the catalyst in order to prepare 3,3-dimethyl-5-(2,2,3-trimethyl-3-cyclopentene-1-base)-4-pentene-2-ketone; and 3, reducing the 3,3-dimethyl-5-(2,2,3-trimethyl-3-cyclopentene-1-base)-4-pentene-2-ketone by adopting potassium borohydride as a reducing agent so as to prepare the polysantalol. The method has the advantages of easy operation and high reaction yield.

Description

technical field [0001] The present invention relates to the synthesis method of polysantalol. Background technique [0002] Polysantalol is a very important new type of sandalwood fragrance. In addition to the elegant sandalwood aroma, it also has a unique sweet and creamy aroma. It is used in daily chemical essence, beauty care products, laundry care products, household supplies. The current synthetic method of polysantalol is complex in operation and low in reaction yield. Contents of the invention [0003] The present invention aims at above-mentioned problem, provides the synthetic method of polysantalol which is easy to operate and has high reaction yield. [0004] The synthetic method of polysantalol: [0005] In the first step, borneol and butanone are subjected to condensation reaction to obtain 3-methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-3-pentene- 2-ketone, the reaction uses potassium hydroxide as a catalyst, and aqueous methanol as a solvent; the second ...

Claims

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Application Information

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IPC IPC(8): C07C33/12C07C29/143
Inventor 章平毅戴晖陆欢沈蔚
Owner SHANGHAI APPLIED TECHNOLOGIES COLLEGE
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