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Method for preparing macroporous adsorbent resin special for separating valine

A technology of adsorption resin and valine, which is applied in the field of adsorption resin and its preparation, and macroporous adsorption resin for valine separation, which can solve the problems of difficult separation, insufficient product purity, complicated separation process, etc., and reduce pollution , high recovery rate and production intensity, to overcome the effect of low purity

Active Publication Date: 2010-06-09
XINTAI JIAHE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the main difficult-to-separate impurities alanine and leucine in valine are neutral amino acids with similar properties, it is difficult to separate
Therefore, the currently adopted methods all have the disadvantages of complicated separation process and insufficient product purity.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take 10g polyvinyl alcohol and 5g NH 4 SO 4 Mix, add distilled water to it to make the volume up to 500 mL to make the water phase substance. Prepare 50 mL of organic phase material, including 8 mL of divinylbenzene and styrene, 3 mL of ethyl acrylate, and 31 mL of 200# gasoline. Di-tert-butyl dicarbonate is 5g. The water phase material was heated to 40°C, and the organic phase material and di-tert-butyl dicarbonate were mixed into the water phase material while stirring. After the mixing was completed, the temperature was raised to 80°C, and the polymerization reaction was carried out for 5 hours. The resin is filtered out, washed and dried to obtain a macroporous adsorption resin with a particle size of 120-150 μm. The column efficiency of valine was detected to be 2203, and the separation between valine and impurities reached 1.83. The purity of the collected valine is 99.15%, and the recovery rate is 80.20%.

Embodiment 2

[0020] Mix 0.5 g of polyvinyl alcohol and 30 g of MgCl, add distilled water to the mixture to make the volume to 500 mL, and make the water phase substance. Prepare 50 mL of organic phase material, of which 15 mL of divinylbenzene, 3 mL of propylene acetate, and 32 mL of toluene. Di-tert-butyl dicarbonate is 0.6 g. The water phase material was heated to 30°C, and the organic phase material and di-tert-butyl dicarbonate were mixed into the water phase material while stirring. After the mixing was completed, the temperature was raised to 70°C, and the polymerization reaction was carried out for 4 hours. The resin is filtered out, washed and dried to obtain a 130-140 μm particle size macroporous adsorption resin. The column efficiency of valine is 2235, and the separation between valine and impurities reaches 1.85. The purity of valine is 98.21%, and the recovery rate is 76.25%.

Embodiment 3

[0022] Take 5g of polyvinyl alcohol and 15g of NaCl mixed, add distilled water to it to make the volume up to 500mL, and make the water phase substance. Prepare 100 mL of organic phase material, of which 30 mL of divinyl toluene, 6 mL of allyl acetate, and 64 mL of n-butanol. Di-tert-butyl dicarbonate is 6g. The water phase material is heated to 35°C, and the organic phase material and di-tert-butyl dicarbonate are mixed into the water phase material while stirring. After the mixing was completed, the temperature was raised to 75°C, and the polymerization reaction was carried out for 4.5 hours. The resin is filtered out, washed and dried to obtain a 130-140 μm particle size macroporous adsorption resin. The column efficiency of valine is 2312, and the separation between valine and impurities reaches 1.86. The purity of valine is 99.42%, and the recovery rate is 81.81%.

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Abstract

The invention relates to a method for preparing macroporous adsorbent resin special for separating valine, and belongs to the technical field of chemical and biological product processing. In the method, the types and proportions of an aqueous phase matter, cross-linking agents, polar monomers and pore-foaming agents are controlled in the process of synthesizing the resin, so that the resin can be bonded with di-tert-butyl dicarbonate effectively, and the synthesized macroporous adsorbent resin can separate the valine, alanine and leucine; and simultaneously, the macroporous adsorbent resin adopts pure water as a mobile phase, so that the pollution of a separation process on environment can be lightened effectively. The resin synthesized by the method can be effectively used for separating valine fermentation liquor and removing impurities with similar properties such as the alanine and the leucine in the valine fermentation liquor, and overcomes the defects of low purity, low efficiency, severe pollution and the like which exist in the conventional process for separating and purifying the valine, so that the purity of products reaches over 99 percent, reaches medicinal standards, and has high recovery rate and production strength.

Description

Technical field [0001] The invention provides a special macroporous adsorption resin for valine separation, relates to an adsorption resin and a preparation method thereof, and belongs to the technical field of chemical and biological product processing. Background technique [0002] Valine (L type) is an essential amino acid for the human body. Because of its special structure and function, it occupies a particularly important position in human life metabolism. It is widely used in the manufacture of medicine, food and flavoring agents, animal feed and cosmetics, and its role in medical research and treatment has also received increasing attention. [0003] At present, the domestic valine extraction process generally uses bacteria or plate and frame filter to remove part of the bacteria, separates with ion exchange resin, concentrates under reduced pressure, recrystallizes or recrystallizes to obtain the finished product of valine. In addition to the main product valine, the vali...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/30C07C229/08C07C227/40
Inventor 丁彦蕊张伟国蔡宇杰廖祥儒王亚辉罗军侠张大兵
Owner XINTAI JIAHE BIOTECH CO LTD
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