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Medicine composition for treating hypertension

A composition and high blood pressure technology, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problem of slow release agent without technical solution and other problems

Inactive Publication Date: 2010-05-26
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patents CN1312715 and CN1733307 disclose a kind of pharmaceutical composition for the treatment or prevention of diabetes, hypertension with diabetes, and diabetic nephropathy, comprising valsartan and calcium channel blockers, but this invention only mentions the use of prior art to make this Pharmaceutical compositions made into tablets, capsules, suppositories
[0004] Chinese patent CN1883478 discloses a pharmaceutical composition for treating hypertensive cardiovascular disease, comprising levamlodipine and losartan, irbesartan, valsartan, eprosartan, candesartan or tasosartan Tan, and discloses that the pharmaceutical composition can be made into tablets, granules, capsules, injections, sustained-release preparations, but the preparation of sustained-release preparations does not give a specific technical solution

Method used

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  • Medicine composition for treating hypertension
  • Medicine composition for treating hypertension
  • Medicine composition for treating hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] The preparation of embodiment 1 compound microporous osmotic pump sheet

[0088] 1. Tablet core prescription:

[0089] Levoamlodipine 5g

[0090] Losartan 2.5g

[0091] Sodium Alginate 15g

[0092] Poloxamer 10g

[0093] Sodium chloride 30g

[0094] HPMC 10g

[0095] Lactose 160g

[0096] Stearic acid 2g

[0097] 3% povidone K30 ethanol solution appropriate amount

[0098]

[0099] Prepared in 1000 pieces

[0100] 2. Prescription of coating solution:

[0101] Cellulose acetate 25g

[0102] Macrogol 4000 15g

[0103] Diethyl phthalate 12ml

[0104] 97% acetone aqueous solution 1000ml

[0105]

[0106] Coated Weight Gain 7%

[0107] 3. Preparation process:

[0108] Pass the prescribed amount of raw materials and auxiliary materials in the tablet core through a 100-mesh sieve, mix evenly, add an appropriate amount of 3% povidone K30 ethanol solution to make a soft material,...

Embodiment 2

[0110] The preparation of embodiment 2 compound microporous osmotic pump sheet

[0111] 1. Tablet core prescription:

[0112] Levoamlodipine 0.5g

[0113] Losartan 300g

[0114] Sodium Alginate 15g

[0115] Poloxamer 5g

[0116] Polyoxyethylene 10g

[0117] Lactose 75g

[0118] Stearic acid 3g

[0119] 3% povidone K30 ethanol solution appropriate amount

[0120]

[0121] Prepared in 1000 pieces

[0122] 2. Prescription of coating solution:

[0123] Ethyl cellulose 30g

[0124]Macrogol 4000 20g

[0125] Hypromellose K4M 10g

[0126] Acetone / ethanol / water (14 / 5 / 1) 1000ml

[0127]

[0128] Coated Weight Gain 7%

[0129] 3, preparation process is the same as embodiment 1

Embodiment 3

[0130] Embodiment 3 Preparation of compound single-chamber single-layer osmotic pump sheet

[0131] 1. Tablet core prescription:

[0132] Levoamlodipine 5g

[0133] Losartan 10g

[0134] Carbomer 934P 30g

[0135] Sodium Lauryl Sulfate 10g

[0136] Potassium chloride 20g

[0137] Sucrose 150g

[0138] Magnesium Stearate 3g

[0139] 5% aqueous solution of hydroxypropylmethylcellulose appropriate amount

[0140]

[0141] Prepared in 1000 pieces

[0142] 2. Prescription of coating solution:

[0143] Ethyl cellulose 30g

[0144] PEG 4000 5g

[0145] Glycerin 10ml

[0146] 97% acetone aqueous solution 1000ml

[0147]

[0148] Coated Weight Gain 8%

[0149] 3. Preparation process:

[0150] Pass the prescribed amount of raw materials and auxiliary materials in the tablet core through a 100-mesh sieve, mix evenly, add an appropriate amount of 5% hydroxypropyl methylcellulose aqueous sol...

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Abstract

The invention belongs to the field of medicine preparations, which relates to a medicine composition containing the active components of levorotatory amlodipine / amlodipine and losartan. Concretely, the medicine composition is an osmotic pump preparation. The osmotic pump preparation contains main medicines, high molecular substances, a surfactant, an osmotic pressure promoter, an osmosis promotion polymer and auxiliary materials of other conventional preparation tablets and a coating. The medicine composition represents an obvious advantage in the indexes of the pressure relief, the sugar tolerance, the urine content of urine trace albumin, blood leucocyte after stress and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a pharmaceutical composition for treating hypertension containing two drug active ingredients, in particular to a pharmaceutical composition containing levoamlodipine / amlodipine and losartan as active ingredients. Background technique [0002] Hypertension is the most common cardiovascular disease and has become a major public health problem worldwide. According to statistics from the national health department, by the end of 2006, the number of hypertensive patients in my country had reached 160 million, and more than 3 million new patients were added every year. Hypertension is a syndrome with very complicated etiology and pathogenesis. Once diagnosed, it requires life-long medication. At present, domestic and foreign medical circles generally tend to use two antihypertensive drugs with different mechanisms of action in combination. According to the sixth report of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61K31/4178A61K9/20A61K9/22A61K9/36A61K47/30A61K47/38A61P9/12
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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