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Method for preparing moisturizing agent N-maleylation-O-carboxymethyl chitosan

A technology of carboxymethyl chitosan and maleylation, which is applied in the direction of cosmetic preparations, pharmaceutical formulations, and preparations for toiletry, etc., can solve the problems of few researches on N-acylation, and meet the needs of a wide range of markets, good Safety and biological activity, effect of improving moisture retention

Inactive Publication Date: 2010-04-21
NANCHANG HANGKONG UNIVERSITY
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0004] At present, more researches are on O-alkylation and O-carboxylation, but little research on N-acylation

Method used

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  • Method for preparing moisturizing agent N-maleylation-O-carboxymethyl chitosan
  • Method for preparing moisturizing agent N-maleylation-O-carboxymethyl chitosan
  • Method for preparing moisturizing agent N-maleylation-O-carboxymethyl chitosan

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Embodiment Construction

[0012] (1) Preparation of O-carboxymethyl chitosan

[0013] The specific method is as follows: take 20g chitosan and soak it in 400ml isopropanol, add a certain concentration of KOH solution (23g KOH is dissolved in 20mL deionized water), soak for more than 5 hours. At room temperature, chloroacetic acid (10 g of chloroacetic acid dissolved in 20 mL of deionized water) was slowly added, and the reaction was stirred for 5 h. After the reaction, the isopropanol was discarded, the product was dissolved in water, the pH was adjusted to 8 with HCl solution, ethanol was added to precipitate the precipitate, and the precipitate was washed with 95% ethanol and absolute ethanol respectively. Vacuum drying at a constant temperature of 60°C to obtain O-carboxymethyl chitosan.

[0014] (2) Preparation of target product N-maleylated-O-carboxymethyl chitosan

[0015] The specific method is as follows: take 2g (0.01 mole) of the above product in a reactor, add 90ml of acetic acid (HAc) sol...

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Abstract

The invention discloses a method for preparing a moisturizing agent N-maleylation-O-carboxymethyl chitosan, which is characterized by comprising the following steps: weighing 2 grams of O-carboxymethyl chitosan, putting the O-carboxymethyl chitosan in a reactor, adding 90 milliliters of acetic acid solution of which volume fraction is 3 percent into the reactor, stirring the mixture to dissolve for 1 hour till forming homogeneous phase solution, weighing maleic anhydride in a molar ratio of 1 to 1 with the O-carboxymethyl chitosan again, then dissolving the maleic anhydride in 5 milliliters of acetone, adding the solution into the reactor by stirring, and reacting the mixture for 15 hours at room temperature; and purifying the product by using the acetone, and drying the purified product in a vacuum constant temperature drying oven at the temperature of 50 DEG C to obtain N-maleylation-O-carboxymethyl chitosan. The method has the advantages that the moisturizing agent N-maleylation-O-carboxymethyl chitosan has better safety and bioactivity compared with other moisturizing agents and has broad market demands.

Description

technical field [0001] The invention relates to a preparation method of a moisturizing agent N-maleoyl-O-carboxymethyl chitosan. Background technique [0002] As a biological macromolecule, chitosan and its derivatives have excellent water absorption and water retention properties. When added to cosmetics, they can not only provide nutrients such as collagen to the skin, but also fill in the dry cracks generated by the epidermis , and the ceramide in the epidermis lipid film layer, and finally grow into one with the epidermis. It can also stimulate and accelerate the regeneration of epidermal cells, so as to achieve the effect of slowing down aging and modifying beauty. Chitosan and its derivatives also have antibacterial properties that hyaluronic acid does not have, and are suitable for the production of various moisturizing creams, shampoos, mousses, ointments, body washes, facial cleansers and other cosmetics, and can completely replace transparent Hyaluronic acid is th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08A61K8/73A61P5/02A61P5/06A61P19/00A61P19/10A61P19/06
Inventor 舒红英戴玉华谢宇
Owner NANCHANG HANGKONG UNIVERSITY
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