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Porous, non-degradable implant made by powder molding

An implant, a molding technique, used in the field of porous implants

Inactive Publication Date: 2010-02-10
CINVENTION AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Increased thickness leads to unfavorable properties, such as increased cross-sectional area of ​​the stent within the target vessel, restricting its use to large vessels or causing mechanically induced hemodynamically relevant thrombosis

Method used

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  • Porous, non-degradable implant made by powder molding
  • Porous, non-degradable implant made by powder molding
  • Porous, non-degradable implant made by powder molding

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0147] Preparation of Slurry A

[0148] A slurry was made with tantalum nanoparticles and irregularly shaped polyethylene beads. Tantalum pellets were purchased from H.C. Starck. Polyethylene beads were purchased from Impag (Microscrub, D50 150 μm). The D50 particle size of the tantalum particles is 100 nm. The slurry contained 500 g tantalum, 200 g polyethylene beads, wetting agent (BykP-104) and ethanol (commercially available from Merck). The granules were mixed with 100 g of humectant and stirred for about 20 min. Suspend 200g polyethylene beads in 200g ethanol for 10min and add to the tantalum pellets. The slurry was homogenized with a conventional stirrer for 1 h.

Embodiment 2

[0150] Preparation of slurry B

[0151] A slurry was made with silica and polyethylene beads. Silica was purchased from Degussa (Aerosil R972) and polyethylene beads were purchased from Impag. Similar to Example 1, a slurry was prepared with 200 g of silica as follows: 100 g of acetone was added, stirred for about 1 h, and then 150 g of polyethylene beads were added. The slurry was homogenized for about 90 min more.

Embodiment 3

[0153] Molding disc-shaped implants from Slurry A: rapid heating

[0154] A standard cylindrical hollow mold made of stainless steel with an inner diameter of 3 cm and a length of 8 cm was used. The mold was filled with Slurry A to 4 / 5 full volume and compacted using a standard spring molding machine to form a green body. A compaction pressure of 50 MPa was then applied for 100 s, and the cycle was repeated 2 more times. The green body is disc-shaped, with a diameter of 2.8 cm and a height of 4 cm. Dry for another 1 h at room temperature and then put into a standard sintering furnace. The green body was sintered as follows: the temperature was raised at a heating rate of 20 K / min, the temperature was kept at 400° C. for 4 hours, and then cooled to room temperature within 20 hours.

[0155] The molded body was cut to analyze the pore structure introduced by the polyethylene bead filler. The molded body has a regular surface structure macroscopically. The microstructu...

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Abstract

The present invention is directed to porous implants and methods for the manufacture thereof which use powder molding techniques. Specifically, the methods include the steps of providing a suspensioncomprising a plurality of first particles of at least one organic polymer; a plurality of second particles of at least one metal-based material; and at least one solvent; wherein the first and secondparticles are substantially insoluble in the solvent; molding the suspension to form a green body comprising the first particles embedded in a matrix of compressed second particles; removing the firstparticles from the green body by thermally induced decomposition and / or evaporation; and sintering the green body to form the implant; wherein the step of removing the first particles is performed during sintering.

Description

technical field [0001] The present invention relates to porous implants and methods of making porous implants using powder molding techniques. Background technique [0002] Implants, short-term or long-term devices intended to be implanted in the human body, are widely used in different fields of application, such as orthopedic, cardiovascular or surgical restoration. Implants are usually made of solid materials such as polymers, ceramics or metals. Implants with porous structures have also been produced to provide improved graft or surrounding tissue ingrowth or adhesion, or to enable drug delivery. Different approaches have been constructed to obtain integrally porous implants (especially in the field of orthopedic applications) or at least implants with a porous surface in which drugs can be incorporated for in vivo release. [0003] Powder metallurgy and powder forming methods have been used to produce implants. For example, US 7,094,371 B2 describes a method for manu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/30B22F3/11
CPCA61F2/3094A61F2002/30677B22F2998/10A61L27/56A61F2240/001A61L2400/18B22F3/1121A61F2310/00011A61F2250/0067A61L27/04A61F2002/3092Y10T428/12153B22F3/227B22F3/02B22F3/225B22F3/22
Inventor 阿斯加里·苏海尔
Owner CINVENTION AG
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