Biodegradable vascular support

Abstract

The invention relates to biodegradable vascular supports consisting of an inner biodegradable metal skeleton and an outer polymeric coating. The biodegradable coating preferably consists of biodegradable polymers and can also contain at least one pharmacologically active substance such as an anti-inflammatory, cytostatic, cytotoxic, anti-proliferative, anti-microtubule, anti-angiogenic, anti-restenotic (anti-restenosis), anti-fungicidal, anti-neoplastic, anti-migrative, athrombogenic and / or antithrombogenic active ingredient.

Description

technical field [0001] The present invention is directed to a biodegradable stent consisting of an inner biodegradable metal framework and an outer polymer coating. The biodegradable coating preferably consists of a biodegradable polymer and may further contain at least one pharmacologically active substance such as an anti-inflammatory agent, a cytostatic agent, a cytotoxic agent, an antiproliferative agent, an anti-tubulin agent, an anti- Angiogenic, antirestenotic or anti-restenosis, antifungal, antineoplastic, antimigratory, nonthrombogenic and / or antithrombogenic agents. Background technique [0002] Today, implanting a stent is a common surgical procedure for the treatment of strictures. Recent studies have shown that narrowed vessels do not have to be permanently expanded by means of endoprostheses, especially stents. Since the presence of the stent-prosthesis in the tissue enables the regeneration of the narrowed part of the vessel and then remains dilated even wit...

AI Technical Summary

Problems solved by technology

[0005] On the one hand, these stents have the disadvantage of dissolving so quickly and uncontrolled that some of them break down after two weeks

[0006] Another disadvantage of these stents is that the required stiffness of these segments is predetermined by the material, so compared to common stent materials such as medical stainless steel, Nitinol and cobalt / chromium stents, the stent struts have a relatively low wide and thick design

The result is a large contact surface with the surroundings, on the other hand the stent can extend further into the chamber and possibly affect blood flow

In addition, the incorporation of the stent in the vessel wall is delayed due to the large surface covered

[0007] In addition, since the dissolution process begins before the stent is incorporated into the vessel wall, fragments that would be transported through the bloodstream may become detached and possibly cause myocardial infarction

[0008] Another disadvantage of the bioabsorbable metal stent is that it offers only very limited convenience for the incorporation into the metal framework of pharmacologically active agents that should be released during the degradation of the stent

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