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Medical catheter carrying slow-release antibiotic coating and preparation method thereof

A medical catheter and antibiotic technology, applied in the field of medical equipment, can solve the problems of inability to achieve antibacterial, reduction of biofilm formation, inability to maintain action time, etc., to achieve the effect of not being able to withstand high temperature and reducing the incidence rate

Inactive Publication Date: 2010-01-20
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the main problems are: 1. The release time of the antibacterial substance is short, and it cannot maintain a long action time; 2. The antibacterial substance is easily denatured in the environment in which the catheter is used, and the purpose of antibacterial cannot be achieved; 3. The antibacterial effect of pathogenic bacteria on the catheter load Substance resistance
Current research shows that they reduce biofilm formation by reducing bacteria through their bactericidal mechanism, but have no effect on mature biofilms

Method used

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  • Medical catheter carrying slow-release antibiotic coating and preparation method thereof

Examples

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Effect test

Embodiment 1

[0024] Such as figure 1 As shown, the slow-release antibiotic coated medical catheter includes a tube body 1 of the urinary catheter, and the outer surface of the tube body 1 of the urinary catheter is coated with an amikacin slow-release layer 2, and the antibiotic slow-release layer 2 is polylactic acid-polyglycolic acid coating combined with amikacin. Wherein the thickness of the amikacin slow-release layer 2 is 10 μm. A method for preparing a slow-release antibiotic-coated medical catheter, comprising the steps of:

[0025] (1) Medical catheter pretreatment: the tube body 1 of the urinary catheter was ultrasonically cleaned in distilled water, acetone, 70% ethanol, and ultrapure water for 5 minutes, 10 minutes, 10 minutes, and 5 minutes, and then cleaned with peroxygen. Stand-by after ethane fumigation and sterilization;

[0026] (2) Configure the acetone solution containing polylactic acid-polyglycolic acid: the low molecular weight polylactic acid-polyglycolic acid of...

Embodiment 2

[0030] Such as figure 1 As shown, the slow-release antibiotic-coated medical catheter includes a tube body 1 of an endotracheal tube, and the outer surface of the tube body 1 of the endotracheal tube is covered with an antibiotic slow-release layer 2, and the antibiotic slow-release layer 2 is a combination of Polylactide-polyglycolic acid coating with subampenem. Wherein the antibiotic slow-release layer 2 has a thickness of 15 μm.

[0031] A method for preparing a slow-release antibiotic-coated medical catheter, comprising the steps of:

[0032] (1) Medical catheter pretreatment: The tube body 1 of the tracheal intubation was ultrasonically cleaned in distilled water, acetone, 70% ethanol, and ultrapure water for 10 minutes, 20 minutes, 20 minutes, and 15 minutes, and then cleaned with peroxygen. Stand-by after ethane fumigation and sterilization;

[0033] (2) Configure the acetone solution containing polylactic acid-polyglycolic acid: the low molecular weight polylactic ...

Embodiment 3

[0037] Such as figure 1 As shown, the slow-release antibiotic-coated medical catheter includes a tube body 1 of an intravenous indwelling needle, and the outer surface of the tube body 1 of the intravenous indwelling needle is coated with an antibiotic slow-release layer 2, and the antibiotic slow-release layer 2 is a combination of Polylactic acid-polyglycolic acid coating with vancomycin. Wherein the vancomycin slow-release layer 2 has a thickness of 5 μm.

[0038] A method for preparing a slow-release antibiotic-coated medical catheter, comprising the steps of:

[0039] (1) Medical catheter pretreatment: The tube body 1 of the intravenous indwelling needle was ultrasonically cleaned in distilled water, acetone, 70% ethanol, and ultrapure water for 8 minutes, 15 minutes, 15 minutes, and 10 minutes, and then treated with peroxygen Stand-by after ethane fumigation and sterilization;

[0040] (2) Configure the acetone solution containing polylactic acid-polyglycolic acid: co...

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Abstract

The invention discloses a medical catheter carrying a slow-release antibiotic coating and a preparation method thereof. The outer surface of a catheter body (1) is coated with an antibiotic slow-release layer (2), and the antibiotic slow-release layer (2) is a high molecular polymer combined with an antibiotic, preferably a polylactic acid-polyglycollic acid coating. The preparation method comprises the following steps: preprocessing the medical catheter; preparing an acetone solution containing polylactic acid-polyglycollic acid; preparing coating liquid; and settling the coating. The invention has the function of obviously lowering the originating rate of the relevant infection of the catheter. The catheter releases the antibiotic from the inside to the outside in a certain time, directly kills bacteria at the periphery of the catheter and solves the technical problem that the antibiotic can not resist high temperature.

Description

technical field [0001] The invention belongs to the field of medical equipment, and in particular relates to a medical catheter with a slow-release antibiotic coating and a preparation method thereof. Background technique [0002] Medical catheters, including urinary catheters, tracheal intubations, intravenous indwelling needles, and central venous catheters, are widely used medical devices in clinical work, and are mainly made of medical rubber and plastic. Medical catheters need to be implanted into the human body for traumatic diagnosis and treatment, and are one of the important treatment methods in clinical work. However, medical catheters have also become an important factor in nosocomial infections, especially catheter-related nosocomial infections have accounted for the first place in nosocomial infections. Catheter-associated nosocomial infections are more likely to occur in immunocompromised patients, diabetics, infants, and the elderly. For example, catheter-re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/08A61L29/16A61L29/06A61L29/04
Inventor 余洪俊费军
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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