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Chewing soft capsule shell, chewing soft capsule drug and prepration method thereof

A soft capsule skin and soft capsule technology, which is applied in capsule delivery, pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve problems such as high mechanical strength, high chewing hardness, and poor chewing sensation

Active Publication Date: 2011-02-16
BEIJING HANGYANG CAPSULE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For this reason, the technical problem to be solved by the present invention is that the mechanical strength of the hard capsule or chewable soft capsule skin in the prior art is large, and the toughness is high, and the chewing hardness is large and the chewing feeling is not good when the user chews this type of soft capsule, thereby Provide a chewable soft capsule with low mechanical strength and toughness

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A method for preparing chewable soft capsule medicine, comprising the steps of:

[0029](1) Weigh 31g gelatin, 20g glycerin, 43g purified water, 0.2g sodium alginate, 0.36g carrageenan, 0.44g pectin, 2g sorbitol, 3g polyvinyl alcohol 400, add purified water and seaweed to the plastic tank sodium carrageenan, carrageenan and pectin and fully mixed, then add sorbitol and polyvinyl alcohol 400 to the plastic tank, and finally add gelatin, fully mix the above raw materials in the plastic tank and set aside;

[0030] (2) The mixed solution mixed in the step (1) was glued at a temperature of 68° C. for 1.5 hours to obtain a glue solution;

[0031] (3) Stabilize the glue obtained by melting the glue in step (2) in the glue tank for 2 hours, flow into the glue box through the rubber hose, and the glue flows out from the gap at the bottom of the glue box, and flows to the rubber wheel directly below the glue box, Form a rubber with uniform thickness;

[0032] (4) compressing t...

Embodiment 2

[0036] A method for preparing chewable soft capsule medicine, comprising the steps of:

[0037] (1) Weigh 25g gelatin, 15g glycerin, 49.5g purified water, 1g sodium alginate, 1g carrageenan, 1g pectin, 2.5g sorbitol, 5g polyvinyl alcohol 400, add purified water and alginic acid to the plastic tank Sodium, carrageenan and pectin are fully mixed, then sorbitol and polyvinyl alcohol 400 are added to the plastic tank, and finally gelatin is added, and the above raw materials are fully mixed in the plastic tank for later use;

[0038] (2) The mixed solution mixed in step (1) was glued at a temperature of 55° C. for 5 hours to obtain a glue solution;

[0039] (3) Stabilize the glue obtained in the glue tank through step (2) for 3 hours, flow into the glue box through the rubber hose, the glue flows out from the gap at the bottom of the glue box, and flows to the rubber wheel directly below the glue box, Form a rubber with uniform thickness;

[0040] (4) compressing the contents in...

Embodiment 3

[0044] A method for preparing chewable soft capsule medicine, comprising the steps of:

[0045] (1) Weigh 35g gelatin, 25g glycerin, 36.2g purified water, 0.1g sodium alginate, 0.1g carrageenan, 0.1g pectin, 1.5g sorbitol, 2g polyvinyl alcohol 400, add purified water to the plastic tank , sodium alginate, carrageenan and pectin and fully mixed, then add sorbitol and polyvinyl alcohol 400 to the plastic tank, and finally add gelatin, fully mix the above raw materials in the plastic tank and set aside;

[0046] (2) Carrying out gelation for 1 hour at a temperature of 75° C. to the mixed solution mixed in step (1) to obtain a glue solution;

[0047] (3) Stabilize the glue obtained by melting the glue in step (2) in the glue tank for 1 hour, then flow into the glue box through the rubber hose, the glue flows out from the gap at the bottom of the glue box, and flows to the rubber wheel directly below the glue box, Form a rubber with uniform thickness;

[0048] (4) compressing the...

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Abstract

The invention relates to a chewing soft capsule shell, a chewing soft capsule drug and a prepration method thereof. The soft capsule shell consists of the following raw materials: 25-35 wt% of gelatin, 15-25 wt% of glycerol, 35-50 wt% of purified water, 0.1-1 wt% of sodium alginate, 0.1-1 wt% of carrageenan, 0.1-1 wt% of pectin, 1.5-2.5 wt% of sorbitol and 2-5 wt% of polyvinyl alcohol 400. The chewing soft capsule shell further comprises the following components: 0.1-0.3 wt% of sweetener, 0.2-0.4 wt% of acidifier, 0.001-0.01 wt% of spice, 0.001-0.01 wt% of preservative and 0.001-0.01 wt% of pigment. The soft capsule shell prepared by the raw materials has the advantages of small mechanical strength and toughness, and the invention further provides the method for preparing the chewing softcapsule drug.

Description

technical field [0001] The invention relates to a soft capsule, in particular to a chewable soft capsule skin and capsule medicine thereof, belonging to the technical field of medicine. Background technique [0002] As an emerging drug delivery system, soft capsules can effectively ensure the good drug stability of the contents due to their unique closed soft packaging characteristics, and are widely used due to their own dose controllability and portability. In recent years, for the purpose of improving the ingestibility of pharmaceutical preparations, there has been an increasing demand for chewable soft capsules that can be easily taken without water. Thus, the chewable soft capsule skin was prepared by adding an appropriate amount of glycerin and sorbitol to the raw material of the soft capsule skin. However, only improving the chewability of the chewable soft capsule skin is far from satisfying the requirements of users, and then came into being the chewable soft capsu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/42A61K47/36A61K47/10A61K47/32A61K9/48
Inventor 霍晋涛周洋程鹏
Owner BEIJING HANGYANG CAPSULE TECH
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