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Sertraline hydrochloride oral liquid and preparation method thereof

A technology for sertraline hydrochloride oral liquid and oral liquid, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve the effect of ensuring curative effect and improving solubility

Inactive Publication Date: 2010-01-13
BEIJING D VENTUREPHARM TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The present invention solves the key problem of the preparation process of sertraline hydrochloride oral liquid-solubility and stability problems, and selects the mixture of hydroxypropyl beta cyclodextrin and sucrose monolaurate which is almost non-toxic and irritating under the usage dose as the preparation method. Solubilizer and stabilizer, thereby providing a kind of sertraline hydrochloride oral liquid with hydroxypropyl beta cyclodextrin and sucrose monolaurate mixture as solubilizer and stabilizer, wherein hydroxypropyl beta cyclodextrin The weight ratio to sucrose monolaurate is 9:1

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Preparation:

[0018] Take an appropriate amount of pure water, heat to boiling, add hydroxypropyl beta cyclodextrin and sucrose monolaurate to dissolve, then add serterin hydrochloride, add methyl paraben, let it cool, add sorbitol, stir to make Dissolve, add orange essence, and filter through a microporous membrane to obtain the product.

Embodiment 2

[0025] Preparation:

[0026] Take an appropriate amount of purified water, heat to boiling, add hydroxypropyl beta cyclodextrin and sucrose monolaurate to dissolve, then add serterin hydrochloride, add propylparaben, let cool, add mannitol, stir to dissolve , then add strawberry essence, and filter through a microporous membrane to obtain.

Embodiment 3

[0029] Preparation:

[0030] Take an appropriate amount of pure water, heat it to boiling, add hydroxypropyl beta cyclodextrin and sucrose monolaurate to dissolve, then add cetrolene hydrochloride, add sodium benzoate, let it cool, add propylene glycol, stir to dissolve, then add strawberries Essence, obtained by filtering through a microporous membrane.

[0031] We compare Example 1 with the current common method (comparative example 1):

[0032] In comparative example 1, surfactant Tween-80 was added, and the amount of hydroxypropyl beta cyclodextrin was 4g;

[0033] In Example 1, under the situation that the amount of other raw and auxiliary materials is basically the same, the surfactant Tween-80 is replaced with the same dose of sucrose monolaurate, and the amount of hydroxypropyl beta cyclodextrin is 0.9g, which is A quarter of the amount of hydroxypropyl beta cyclodextrin in Comparative Example 1 is obviously better than that of Comparative Example 1.

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PUM

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Abstract

The invention discloses a sertraline hydrochloride oral liquid and a preparation method thereof. The sertraline hydrochloride oral liquid has the advantages of convenient administration, steady storage at low temperature or normal temperature, quick absorption, good mouthfeel, more suitability for senile patients, simple process and material conservation.

Description

technical field [0001] The invention relates to a sertraline hydrochloride oral liquid and a preparation method thereof, in particular to an oral liquid using a mixture of hydroxypropyl beta cyclodextrin and sucrose monolaurate as a solubilizer and a stabilizer and a preparation method thereof. Background technique [0002] Sertraline is the newest of the selective serotonin recapture inhibitors (SSRIs), which can help improve the body's ability to effectively relieve patients' depressive symptoms, including restlessness, and reduce persistent Fatigue symptoms and anxiety state, with long-term effect, low toxicity to liver cells, fast clearance in the body, very suitable for the elderly, etc., has been widely used in the treatment of depression and obsessive-compulsive disorders in the world. [0003] Disclosed in CN1771920A is an orally disintegrating tablet containing sertraline and a preparation method thereof. This sertraline orally disintegrating tablet includes a mixtu...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/00A61K31/135A61K47/40A61P25/26A61P25/24A61P25/18A61K47/48
Inventor 吕青远
Owner BEIJING D VENTUREPHARM TECH DEV
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