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Triptolide transdermal patch and preparation method thereof

A technology of triptolide and transdermal patch is applied in the field of transdermal patch containing active ingredient triptolide and transdermal patch, which can solve the problem of inconvenience for patients to use at any time and the like

Inactive Publication Date: 2010-12-29
北京化药科创医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this preparation can directly reach the lesion, it needs to be injected with the help of medical staff when it is used, and it is not convenient for patients to use it independently at any time

Method used

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  • Triptolide transdermal patch and preparation method thereof
  • Triptolide transdermal patch and preparation method thereof
  • Triptolide transdermal patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 to 3

[0014] In each embodiment, the prescription amount of pressure-sensitive adhesive (acrylic pressure-sensitive adhesive or silicone pressure-sensitive adhesive) is added to absolute ethanol, fully stirred to dissolve; another prescription amount of the drug component triptolide Alcohol, dissolve with absolute ethanol, the viscosifying agent of recipe quantity, transdermal absorption promoter (azone or menthol), join in the above-mentioned drug-containing ethanol solution, stir to fully dissolve, make glue, and above-mentioned Mix the ethanol solution of the pressure-sensitive adhesive, stir evenly, and degas the bubbles by ultrasonication for 30 minutes. At this time, the glue liquid should be clear and transparent. Then apply the glue solution on the backing layer material on the coating machine to prepare the drug storage layer, and dry it at 60±5°C for 2-3 hours. After drying, cover the anti-adhesive layer. Finally, it is punched into a patch of required size to obtain tript...

Embodiment 4

[0021] Embodiment 4 pharmacology and toxicology embodiment

[0022] The safety and effectiveness of the present invention are verified from pharmacological and toxicological tests below.

[0023] In order to evaluate its safety and provide a basis for the safe application of the drug, we have carried out relevant toxicity studies on the triptolide transdermal patch provided by the present invention.

[0024] - Acute skin toxicity test

[0025] Choose 10 healthy adult Wistar rats, half male and half male, weighing 220-250g. Use the one-time limit method. 24 hours before the start of the test, cut off the coat on the back of the animal torso to be exposed. Care should be taken to remove the hair so as not to damage the skin. In order not to affect the permeability of the skin, according to the dose of 100mg / kg, cut the triptolide transdermal patch with a drug content greater than 10mg / paste, and stick it on the depilatory area (range 3-4cm) on the back of the animal. 2 ), cove...

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PUM

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Abstract

The invention relates to a triptolide transdermal patch, which is prepared by a therapeutically effective amount of triptolide, polyvinylpyrrolidone, a certain amount of pressure-sensitive adhesive, tackifier and penetration enhancer, and the triptolide transdermal patch has the advantages of high transdermal absorption rate and small local irritation on skin, thereby being an ideal triptolide preparation.

Description

technical field [0001] The invention relates to a transdermal patch, in particular to a transdermal patch containing triptolide as an active ingredient, and belongs to the field of pharmaceutical preparations. Background technique [0002] Triptolide, also known as triptolide, is a white crystal, insoluble in water, soluble in organic solvents such as dimethyl sulfoxide, acetone, ethanol, etc. Triptolide is isolated from Tripterygium wilfordii The diterpene lactone compound is one of the main active ingredients of Tripterygium wilfordii. It has stable chemical properties in the body and strong physiological activity. Anti-tumor, anti-inflammatory, immunosuppressive and other effects, clinically used to treat psoriasis, rheumatoid arthritis and leukemia, etc., and achieved good curative effect. [0003] Long-term use of triptolide can cause many adverse reactions clinically, mainly in the digestive system, skin and mucous membranes, urinary system and reproductive system, am...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/365A61P17/06A61P19/02A61P19/04A61P35/02
Inventor 关屹闫冬
Owner 北京化药科创医药科技发展有限公司
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