Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Anti-inflammatory and antimicrobial uses for bioactive glass compositions

A bioactive glass and composition technology, applied in the direction of drug combination, inorganic active ingredients, fluorine compound active ingredients, etc., can solve the problems of difficult preparation of growth factors, harmful corticosteroids, time consumption, etc., to shorten the healing time and reduce bacteria presence, increasing the effect of successful

Inactive Publication Date: 2009-12-09
BIOMATERA INC
View PDF3 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods are limited due to the difficulty of preparing growth factors, the time consumption of preparing cell cultures and the high cost of such treatments
And it is still unknown whether there are potential side effects associated with such therapies, such as harmful side effects associated with long-term use of corticosteroids

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0107] Example 1: Treatment of wounds with micronized bioactive glass in a carrier

[0108] The wound of a patient who develops vasculitis soon after the injury is taken as a photo. This type of wound typically requires a complete healing time of about 3 months. This wound treatment uses non-interconnected micronized bioactive glass with fine particles. , Topical antibiotics, including sulfadiazine, and a mixture of petrolatum matrix carrier.

[0109] After treatment with the bioactive glass composition, that is, 4 days after the first picture was taken, a second picture of the same wound was taken, and the third picture of the same wound was taken 7 days after the second picture. The 4 photos were taken 14 days after the second was taken. These photos prove that the wounds healed well. Similar wounds in patients with vasculitis cannot be expected to take at least 3 months to show similar healing.

[0110] For example, the second photo shows that after only 4 queens, the leakage a...

Embodiment 2

[0111] Example 2. Treatment of delayed healing in diabetic patients

[0112] Diabetics suffering from delayed healing damages use micronized bioactive glass with a particle size of less than 40μm and an equal volume of NEOSPORIN TM A mixture of antibiotic ointment to treat. This kind of ointment is mainly a mixture of antibiotic substances based on petroleum jelly. The mixture is directly used for healing delayed lesions about 1 / 2cm long and 1 / 2cm wide. These damages generally do not heal for more than 14 days, and the mixture is used for one day 2 times. Leakage stopped within 24 hours. Wound closure and healing were completed within 5 days. Within 48 hours, scar tissue appeared around the edge of the wound.

[0113] When the scar tissue continues to develop, its appearance is closer to the surrounding tissue than the typical appearance of the type of injury being treated in this patient. After the development is complete, the appearance of the scar tissue is almost close to the ...

Embodiment 3

[0114] Example 3. Antibacterial properties of bioactive glass

[0115] Small micronized bioactive glass and highly porous bioactive glass have antibacterial activity. In an aqueous solution, bioactive glass containing 45% silica, 24.5% sodium oxide, 24.5% calcium oxide and 6% phosphorus oxide The composition raises the pH in an aqueous solution. Subsequent experiments were performed to prove the antibacterial properties of the final solution.

[0116] Nutrient broth (10ml) was added to 5g of micronized bioactive glass with a hole size of 355 to 500μm, 5g of glass beads (not bioactive glass) with a particle size of 455 to 600μm, and no Glass beads. The resulting solution was rotated and incubated at 37°C for 1 hour. 950μl of supernatant was taken out and added to 50μl S. Sanguis cultured overnight, and incubated at 37°C for 1 hour. The survival number was determined by live count. It was observed that the average reduction in the number of live bodies in the bioactive glass superna...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Compositions and methods for treating wounds to significantly reduce the healing time, reduce the incidence of scar formation, improve the success of skin grafts, reduce the inflammatory response and providing anti-bacterial treatments to a patient in need thereof, that include small non-interlinked particles of bioactive glass or highly porous bioactive glass, are disclosed. Anti-bacterial solutions derived from bioactive glass, and methods of preparation and use thereof, are also disclosed. The compositions include non-interlinked particles of bioactive glass, alone or in combination with anti-bacterial agents and / or anti-inflammatory agents. The compositions can include an appropriate carrier for topical administration. Anti-bacterial properties can be imparted to implanted materials, such as prosthetic implants, sutures, stents, screws, plates, tubes, and the like, by incorporating small bioactive glass particles or porous bioactive glass into or onto the implanted materials. Anti-bacterial properties can also be imparted to devices used for in vitro and ex vivo cell culture by incorporating non-interlinked particles of bioactive glass into the devices. Anti-bacterial compositions derived from aqueous extracts of bioactive glass are also disclosed. These compositions can be used, for example, in food preparation, solutions used for cell culture, and buffer solutions, such as i.v. solutions.

Description

[0001] This application is a divisional application of the invention patent application with the application date of September 10, 1999 and the title of the invention "The application of bioactive glass composition in anti-inflammatory and anti-microbial applications". The original Chinese patent application number is 99813123.7 . Technical field [0002] The present invention relates to compositions containing bioactive glass, water extracts obtained from these compositions, cosmetics containing these compositions, implants containing these compositions, and the use of these compositions to promote healing, reduce inflammation and Methods of bacterial infection. More particularly, the present invention relates to a composition containing bioactive glass-containing microparticles, optionally containing one or more substances that facilitate the delivery and distribution of these microparticles and also have other therapeutic effects, and the application of these compositions method...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K33/42A61K8/25A61P31/02A61P17/02A61Q1/12A61Q5/02A61Q5/10A61Q19/10C03C4/00A61K33/00A61K33/08A61K33/16
Inventor D·C·格林斯潘J·K·韦斯特S·李J·L·梅耶尔斯M·迪尔蒙德
Owner BIOMATERA INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com