Application of palmatine in medicine for treating yellow fever virus infection

Abstract

The invention discloses an application of palmatine for preparing medicine for treating and preventing yellow fever virus infection; the inhibition ratio of palmatine to yellow fever virus (YFV) under the condition that the concentration of the palmatine is 100mu m is 96.58 percent, and the survival rate of Vero cells is 92.93 percent under the condition that the concentration of the palmatine is 100mu m. The palmatine can effectively inhibit proliferation of yellow fever virus, but has low cytotoxicity, therefore, the palmatine can be further developed into the medicine for treating diseases caused by yellow fever virus infection and has wide application prospect.

Description

technical field [0001] The invention belongs to the field of biomedicine, and more specifically relates to the application of palmatine in the preparation of medicines for treating or preventing yellow fever virus infection. Background technique [0002] Yellow fever virus (yellow fever virus, YFV) is a member of the Flavivirus genus of the family Flaviviridae, which also includes West Nile virus, dengue virus, and Japanese encephalitis virus. Yellow fever virus causes yellow fever, an acute infectious disease. Yellow fever has been designated as a quarantine infectious disease internationally, and China has also designated it as a Class A infectious disease. In 1648, the YUCATAN peninsula in America first confirmed the prevalence of yellow fever. From the 17th to the 19th century, the disease was brought to Europe and North America through transportation. Within two centuries, yellow fever became one of the most serious plagues in some parts of the United States, Africa, ...

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Problems solved by technology

So far, there have been no cases reported in China, but this does not make us relax our vigilance against the virus, because China's climate and geographical environment are complex, and there are many types of mosquitoes, which have the conditions for transmission. At the same time, with the increasing frequency of international exchanges, YFV It is very likely that it will be introduced into China

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