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Medicament composition for treating hyperammonemia and preparation method thereof

A technology for hyperammonemia and drug activity, applied in the field of arginine glutamate injection, can solve problems such as abnormal ion state, achieve the effects of relieving hyperammonemia, restoring liver function, and avoiding serious organ damage

Inactive Publication Date: 2009-12-09
FUREN PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When used in the treatment of hyperammonemia, the use of large amounts of sodium glutamate or arginine hydrochloride can cause the patient's already dangerous ion state to be disturbed

Method used

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  • Medicament composition for treating hyperammonemia and preparation method thereof
  • Medicament composition for treating hyperammonemia and preparation method thereof
  • Medicament composition for treating hyperammonemia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1, put the refined glutamic acid in the liquid preparation tank, add 9 / 10 prescription water for injection, stir to dissolve, add acid-base buffer solution to adjust the pH value to 6.2-6.5, replenish the water for injection to the full amount, add 0.05% (g / v) Activated carbon, stirred and adsorbed for 15 minutes, decarbonized, finely filtered with 0.45 μm and 0.22 μm microporous membranes, potted, sterilized by circulating steam at 115°C for 10 minutes, leak detection, light inspection, sampling full inspection, Package.

[0032] Functions and Indications: Indications: It is used to treat hyperammonemia caused by acute and chronic liver diseases such as liver cirrhosis, fatty liver and hepatitis, especially for the relief of central nervous system symptoms and rescue of hepatic coma caused by liver diseases.

[0033] Usage and dosage: depending on the patient's condition and rescue situation, 2-20g each time, diluted with glucose injection and injected intra...

Embodiment 2

[0034] Example 2, put refined glutamic acid in the liquid preparation tank, add 9 / 10 prescription water for injection, stir to dissolve, add acid-base buffer to adjust the pH value to 6.2-7.0, replenish the water for injection to the full amount, add 0.1% (g / v) Activated carbon, stirred and adsorbed for 15 minutes, decarbonized, finely filtered with 0.45 μm and 0.22 μm microporous membranes, potted, sterilized by circulating steam at 115°C for 30 minutes, leak detection, light inspection, sampling full inspection, Package.

[0035] Functions and Indications: Indications: It is used to treat hyperammonemia caused by acute and chronic liver diseases such as liver cirrhosis, fatty liver and hepatitis, especially for the relief of central nervous system symptoms and rescue of hepatic coma caused by liver diseases.

[0036] Usage and dosage: depending on the patient's condition and rescue situation, 2-20g each time, diluted with glucose injection and injected intravenously.

Embodiment 3

[0037] Example 3, put the refined glutamic acid in the liquid preparation tank, add 9 / 10 prescription water for injection, stir to dissolve, add acid-base buffer solution to adjust the pH value to 6.2-7.0, replenish the water for injection to the full amount, add 0.1% (g / v) Activated carbon, stirred and adsorbed for 15 minutes, decarbonized, finely filtered with 0.45μm and 0.22μm microporous membranes, potted, sterilized by circulating steam at 115°C for 60 minutes, leak detection, light inspection, sampling full inspection, Package.

[0038] Functions and Indications: Indications: It is used to treat hyperammonemia caused by acute and chronic liver diseases such as liver cirrhosis, fatty liver and hepatitis, especially for the relief of central nervous system symptoms and rescue of hepatic coma caused by liver diseases.

[0039] Usage and dosage: depending on the patient's condition and rescue situation, 2-20g each time, diluted with glucose injection and injected intravenous...

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Abstract

The invention provides a medicament composition for treating hyperammonemia and a preparation method thereof. The medicament composition uses an extractive glutamic acid as an active component and is an extractive glutamic acid injection used for treating the hyperammonemia caused by acute and chronic liver diseases, such as cirrhosis, fatty liver and hepatitis, and is specially suitable for eliminating central nervous system symptoms caused by the liver diseases and the emergency treatment of hepatic coma.

Description

technical field [0001] The invention relates to a pharmaceutical composition for injection containing arginine glutamic acid, which is an arginine glutamic acid injection for treating hyperammonemia caused by acute and chronic liver diseases such as liver cirrhosis, fatty liver, and hepatitis. It is especially suitable for the relief of central nervous system symptoms caused by liver diseases and the rescue of hepatic coma. It belongs to the pharmaceutical field. Background technique [0002] my country is a high-incidence area of ​​hepatitis B. Chronic asymptomatic hepatitis B virus carriers account for about 10% of the total population, and their number exceeds 120 million. Hepatitis has become the most common critical and refractory disease in the Department of Infectious Diseases (Infectious Diseases Department) in China. Chronic severe hepatitis is the most common clinical type of severe hepatitis in my country. Hepatic encephalopathy is a common complication of chron...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K47/12A61P1/16
Inventor 朱成功
Owner FUREN PHARMA GROUP
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