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Method for producing through-hole structure in PDMS micro-fluidic chip

A technology of microfluidic chip and manufacturing method, which is applied in the field of lab-on-a-chip, can solve problems affecting the application of microfluidic chip, damage the structure of microfluidic chip, and irregular shape of through holes, etc., and achieve batch processing and production, Improve the production density and ensure the effect of regularity

Active Publication Date: 2013-07-03
上海前瞻创新研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method is simple and fast, due to the high elasticity of the PDMS material, it is easy to shift the position of the hole due to the deformation of the PDMS during the drilling process, thereby damaging the structure of the microfluidic chip; It is easy to cause the irregular shape of the through hole, which affects the application of microfluidic chips

Method used

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  • Method for producing through-hole structure in PDMS micro-fluidic chip
  • Method for producing through-hole structure in PDMS micro-fluidic chip
  • Method for producing through-hole structure in PDMS micro-fluidic chip

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Example 1. Fabrication of through-hole structures used as sample inlet and sample outlet on the PDMS microfluidic chip

[0023] 1.1 Magnetic microcolumn immobilization

[0024] The present invention can be used to make the through-hole structure of sample inlet and sample outlet on PDMS microfluidic chip, as figure 1 As shown, first, a microfluidic chip mold 1 is made by photolithography, and the chip mold 1 is placed in a container 2 kneaded by aluminum foil; then, a stainless steel plate 3 is placed at the bottom of the container corresponding to the chip mold, and placed on the chip Place the micro-magnetic column 4 above the mold corresponding to the position where the through-hole structure is to be made, and fix it with magnetic force; after fixing the micro-magnetic column, pour PDMS mixed with PDMS prepolymer and curing agent (mass ratio 10:1) in the container The prepolymer is placed on a hot plate at 80°C to cure for 1 hour; after the PDMS is cured, the stain...

Embodiment 2

[0029] Example 2. Fabrication of a high-density through-hole structure on a PDMS microfluidic chip

[0030] If multiple through-hole structures are to be made on the PDMS microfluidic chip, and the distance between the through-holes is small, the mutual magnetic force between adjacent magnetic columns will cause the position of the magnetic columns to shift, affecting the positioning and fixing of the micro-columns. ; In order to avoid the impact of the mutual magnetic force between adjacent magnetic columns on the positioning and fixing of the micro-columns when making a higher-density through-hole structure on the PDMS microfluidic chip, the following methods can be used to fix the micro-columns (such as Figure 4Shown): first cast a plate 8 based on PDMS material, and make a group of small holes on this plate with a puncher, the center position of the small hole basically corresponds to the center of the through hole to be made on the mold, and the diameter of the small hole...

Embodiment 3

[0031] Example 3. Fabrication of a through-hole structure connecting different micropipe layers on a PDMS microfluidic chip

[0032] The present invention is also used to make through-hole structures connected to different micropipe layers on the PDMS microfluidic chip, such as Figure 5 and Image 6 As shown, at first the bottom micropipeline layer mold and the upper micropipeline layer mold containing the micro-through-hole structure are made respectively. Under the aluminum foil paper container 2 equipped with the chip mold 1, the fixing of the stainless steel micro-column at the position of the through hole is realized. The difference from Example 2 is that the bottom chip mold 1 is fixed with a group of magnetic force for making the chip opening structure. In addition to the stainless steel microcolumns 6, a group of stainless steel microcolumns 9 with a smaller diameter for making connection through-hole structures are also fixed. After fixing the microcolumns, pour th...

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Abstract

The invention discloses a method for producing a through-hole structure in a PDMS micro-fluidic chip, which is characterized in that a micro-column or a micro-tube is fixed at the position on the chipmold where a through-hole structure is planed to be produced with the auxiliary magnetic attraction, and then PDMS preformed polymer is integrally poured and curing bonded for producing the PDMS micro-fluidic chip having through-hole structure with a high depth-to-width ratio. The invention provides a method for shaping a micro-fluidic chip and producing a through-hole at one time, which simplifies the micro-fluidic chip production technique, and improves the accuracy of through-hole production by the fixing of the micro-column or the microtubule and the chip mold, with integral pouring implement, thereby guaranteeing the regular shape of the through-hole and avoiding the problems of the irregular through-hole shape and damaged micro-tube structure or the like. In addition, the micro-magnetic column arrangement is inlaid and fixed by the prefabricated mold, which can improve the density of the through-hole production too and realize mass processing and production.

Description

technical field [0001] The invention relates to a method for manufacturing a through-hole structure in a PDMS microfluidic chip, which can be applied to a laboratory on a chip. Background technique [0002] In recent years, microfluidic chips, as a new technology platform, have received widespread attention in the fields of biology and chemistry, and are currently one of the most active areas of development. The materials for making microfluidic chips mainly include silicon wafers, glass, quartz, and high molecular polymers. Among them, polydimethylsiloxane (PDMS) is widely used in the processing and manufacturing of microfluidic chips due to its advantages such as convenient processing, low price, durability, chemical inertness, and good biocompatibility. In the fabrication process of the PDMS microfluidic chip, it is of great significance to form a through-hole structure for connecting the PDMS microfluidic chip with the outside world or connecting the micropipes and micr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B81C5/00B81C3/00B81C1/00B81C99/00
Inventor 李刚陈强李俊君赵建龙
Owner 上海前瞻创新研究院有限公司
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