Intermittent hypoxia big and small mice feeding cabin of linear track type

Abstract

The invention relates to an experimental animal feeding cabin, which is the big and small mice feeding cabin for simulating the symptom of intermittent anaerobic respiration of animal. One side of hypoxia feeding cabin is further connected with a buffering cabin formed from a closed cabin body and a feeding cage track such that the feeding cabin loading the big mouse is timed to stay between the hypoxia feeding cabin and the outside along the feeding cage track so as to simulate the big mouse model of SAS by the long-period intermittent breathing hypoxia gas. There is no need to timely and frequently discharge the nitrogen in the hypoxia feeding cabin, thus, the consumption quantity of the nitrogen is greatly reduced and the experiment cost is reduced by a wide margin.

Description

technical field [0001] The invention relates to an experimental animal feeding cabin, in particular to a feeding cabin for rats and mice with intermittent hypoxia that simulates various respiratory symptoms. Background technique [0002] Sleep apnea syndrome (sleep apnea syndrome, SAS), especially obstructive sleep apnea-hyponea syndrome (OSAHS), is a chronic sleep-respiratory disorder with a high incidence, which seriously affects people's physical and mental health. SAS refers to 7 hours of sleep per night, with more than 30 repeated episodes of apnea or sleep disordered breathing time index (respiratory impairment time index, RIT, that is, the average number of sleep apnea + hypopnea per hour) ≥ 5 times. This leads to recurrent hypoxemia and hypercapnia, which can have various effects on the body: such as drowsiness, dizziness, fatigue, abnormal mental behavior, and morning headaches. As the disease progresses, severe complications such as pulmonary hypertension, pulmon...

AI Technical Summary

Problems solved by technology

But all there is a same problem in this SPF level intermittent hypoxia rat feeding cabin and other existing feeding cabins, promptly when intermittently regulating the oxygen content in the feeding cabin, be by charging nitrogen and emptying feeding in the feeding cabin The nitrogen-containing gas in the cabin can reach the maximum level, so a certain amount of nitrogen is consumed in each cycle, and the consumption is proportional to the volume of the feeding cabin, so a large amount of nitrogen is consumed to complete an experiment, and the cost of the experiment is quite expensive

In addition, the airflow is very noisy every time the nitrogen is replenished, and the animal will be startled when the airflow suddenly rushes out when the solenoid valve is opened

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