Antibacterial composite antibiotic and uses thereof

An antibiotic and anti-bacterial technology, applied in the direction of application, fungi, biocides, etc., can solve the problem of poor anti-bacterial effect

Inactive Publication Date: 2009-11-25
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in the process of actually screening anaerobic fungi, a single antibiotic is generally used to kill bacteria, and long-term use can easily cause bacteria to develop resistance, and the antibacterial effect is poor. Therefore, it is necessary to propose a compound antibiotic suitable for long-term use to achieve better results. Effect

Method used

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  • Antibacterial composite antibiotic and uses thereof
  • Antibacterial composite antibiotic and uses thereof
  • Antibacterial composite antibiotic and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The configuration of embodiment 1 compound antibiotic

[0044] Take 9ml of liquid or solid fungal culture solution in an anaerobic tube, and sterilize at 121°C for 20 minutes;

[0045] Take a bottle of 0.48g 800,000 units penicillin sodium injection powder and dissolve it in 6ml sterile water, add 0.15ml to 9ml anaerobic fungal culture medium with a 1ml sterile syringe;

[0046] Dissolve 60mg of chloramphenicol in 3ml of absolute ethanol, and add 0.1ml to 9ml of anaerobic fungal culture medium with a 1ml sterile syringe;

[0047] Take a bottle of 1g 1 million units streptomycin sulfate dissolved in 8.3ml sterile water, add 0.05ml to 9ml anaerobic fungal culture medium with a 1ml sterile syringe;

[0048] Take 1ml of metronidazole injection and dilute to 6.25ml with sterile water, add 0.15ml to 9ml of anaerobic fungal culture medium with a 1ml sterile syringe.

Embodiment 2

[0049] The configuration of embodiment 2 compound antibiotics

[0050] Take a bottle of 0.48g 800,000 units of penicillin sodium powder for injection and dissolve it in 9ml of sterile water; take 60mg of chloramphenicol and dissolve it in 6ml of absolute ethanol; take a bottle of 1g of 1 million units of streptomycin sulfate and dissolve it in 16.6 ml of sterile water; take 1ml of metronidazole injection and dilute to 12ml with sterile water.

[0051] Take 9ml of penicillin sodium solution, 6ml of chloramphenicol solution, 3ml of streptomycin sulfate solution, and 6ml of metronidazole solution and mix to prepare compound antibiotics.

Embodiment 3

[0052] The configuration of embodiment 3 compound antibiotics

[0053] Take a bottle of 0.48g 800,000 units of penicillin sodium powder for injection and dissolve it in 3ml of sterile water; take 60mg of chloramphenicol and dissolve it in 2ml of absolute ethanol; take a bottle of 1g of 1 million units of streptomycin sulfate and dissolve it in 4.5 ml of sterile water; take 1ml of metronidazole injection and dilute to 3.6ml with sterile water.

[0054] Take 3ml of penicillin sodium solution, 2ml of chloramphenicol solution, 1ml of streptomycin sulfate solution, and 3ml of metronidazole solution and mix to prepare compound antibiotics.

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Abstract

The invention provides a composite antibiotic, containing penicillin sodium, chloromycetin, streptomycin sulfate and metronidazole at the weight ratio of 300-1200 to 50-200 to 150-625 to 3-12. the invention also provides a use of the composite antibiotic, specially adapted for sterilizing in the screening and culturing anaerobic fungal process. In the invention, penicillin sodium, chloromycetin, streptomycin sulfate and metronidazole with different species and concentrations are formulated, the antibacterial effect is remarkable; the composite antibiotic has simple compatibility and strong operability, is suitable for industrial production, and has higher use value especially in the feedingstuff, papermaking, fungal enzyme preparation production.

Description

technical field [0001] The invention relates to the field of compound antibiotics, in particular to an antibacterial compound antibiotic and its application. Background technique [0002] Anaerobic fungi can secrete a variety of enzymes that degrade cellulose, mainly including cellulase, hemicellulase, xylanase, galacturonase, etc. The hemicellulose is separated from lignin and hemicellulose composites, thereby degrading and fermenting various structurally complex substrates such as cellulose, xylan, glucose, etc., producing formic acid, acetic acid, ethanol, CO 2 and H 2 etc., this degradation is mainly accomplished through the mechanical invasion of its abundant rhizoid system and the chemical degradation of various highly active enzymes produced. In the digestive tract of animals, anaerobic fungi can preferentially attach and degrade lignified fibrous tissue, which is beneficial to the further action of other enzymes on hemicellulose. The efficient degradation of straw...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N47/44A01N43/90A01N37/20A01N43/50A01P1/00C12N1/14C12Q1/04
Inventor 杨红建曹阳春岳群刘晶晶商圣哲
Owner CHINA AGRI UNIV
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