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WuRenChun self-emulsifying soft capsule preparation and preparation method

A technology of self-emulsifying soft capsules and pentalinol, which is applied in the field of medicine to improve water solubility and bioavailability and reduce serum alanine aminotransferase

Active Publication Date: 2011-11-02
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, there are three kinds of patents applied for Wurenchun preparations, Wurenchun dripping pills and its preparation method, Wurenchun soft capsule preparations and compound Wurenchun soft capsule preparations. Literature reports and patent applications

Method used

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  • WuRenChun self-emulsifying soft capsule preparation and preparation method
  • WuRenChun self-emulsifying soft capsule preparation and preparation method
  • WuRenChun self-emulsifying soft capsule preparation and preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0053] Prescription Composition Weight

[0054] Pentalenol 50g

[0055] Oleic acid 50g

[0056] Tween 20 162.5g

[0057] Transcutol P 37.5g

[0058] ---------------------------------------------

[0059] Composition ratio of soft capsule shell (W / W):

[0060] gelatin (dry) 1

[0061] Glycerin 0.55

[0062] Distilled water 1.2

[0063] Ethylparaben 0.001

[0064] --------------------------------------------

[0065] Make 1000 capsules

[0066] Preparation Process:

[0067] The raw material drug of pentarenol was purchased from Xi'an Xiaocao Plant Technology Co., Ltd.; the oil phase, surfactant and co-surfactant are all commercially available products.

[0068] (1) Weigh the oil phase, surfactant, and co-surfactant according to the formula, and mix thoroughly by ultrasonic at 25°C, then add the prescribed amount of pentene alcohol raw material, and mix completely by ultrasonic within 40°C until the drug is completely Dissolve, and the obtained medicine is pressed int...

Embodiment 2

[0073] Prescription Composition Weight

[0074] Pentalenol 50g

[0075] Oleic acid 62.5g

[0076] Tween 20 175g

[0077] Transcutol P 12.5g

[0078] ----------------------------------------

[0079] Make 1000 capsules

[0080] Preparation method: with embodiment 1

Embodiment 3

[0082] Prescription Composition Weight

[0083] Pentalenol 50g

[0084] Oleic acid 62.5g

[0085] Polyoxyethylene hydrogenated castor oil 162.5g

[0086] 1,2-propanediol 25g

[0087] ------------------------------------------

[0088] Make 1000 capsules

[0089] Preparation method: with embodiment 1

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Abstract

The invention relates to a WuRenChun self-emulsifying soft capsule preparation and a preparation method; WuRenChun (Shizandra ethanol extract containing 2-5% (W / W) of Schizandrol A and 1-3% (W / W) of Schizandrin B) is used for preparing the self-emulsifying soft capsule for curing acute, chronic and metastatic hepatitis, and reducing serum glutamic pyruvic transminase. The WuRenChun self-emulsifying soft capsule preparation comprises: WuRenChun, oil phase, surfactant and auxiliary surfactant, and the component proportion is 1:0.25-3.25:1.5-3.5:2.5-1.25. The preparation method is : the oil phase, the surfactant and the auxiliary surfactant are mixed evenly, the WuRenChun bulk drug is added to be mixed fully with intravascular ultrasound at 40 DEG C until the drug is fully dissolved, the obtained content is pressed into soft capsules according to the conventional method. The invention can enhance the dissolution degree of the WuRenChun, improve the bioavailability and then improve the healing effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a pentarenol self-emulsifying soft capsule preparation and a preparation method. Background technique [0002] The traditional Chinese medicine Schisandrae chinensis (Fructus schisandrae chinensis) is the dry ripe fruit of Magnoliaceae plant Schisandrae chinensis (Turcz) Baill. In my country, the schisandra produced in the provinces north of the Yangtze River is called northern schisandra, and the schisandra produced in the south of the Yangtze River, mainly in Zhejiang and Fujian, is called southern schisandra. The quality of northern schisandra is better than that of southern schisandra, and our province is the main producing area of ​​northern schisandra. Wurenol is the alcohol extract of Schisandra chinensis, which has the function of nourishing the liver and kidney. It is used for acute, chronic, and persistent hepatitis. Commercially available Wurenchun single and compound...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/57A61K9/48A61K47/44A61K47/24A61K47/34A61P1/16A61K47/10A61K47/12A61K47/14A61K47/26
Inventor 吴琳华唐景玲邵兵
Owner HARBIN MEDICAL UNIVERSITY
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