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Applications of dendrobium nobile lindl alkaloids in medicines prepared for treating ischemic brain damage and product thereof

A technology for ischemic brain injury and Dendrobium nobile can be applied in drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve problems such as unclear pharmacological effects and mechanisms

Active Publication Date: 2009-09-23
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pharmacological action and mechanism of the above-mentioned Dendrobium nobile plants and the total alkaloids of Dendrobium nobile are still unclear, and further research and exploration are needed.

Method used

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  • Applications of dendrobium nobile lindl alkaloids in medicines prepared for treating ischemic brain damage and product thereof
  • Applications of dendrobium nobile lindl alkaloids in medicines prepared for treating ischemic brain damage and product thereof
  • Applications of dendrobium nobile lindl alkaloids in medicines prepared for treating ischemic brain damage and product thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0185] Embodiment 1 of the present invention: the extraction of total alkaloids of Dendrobium nobile:

[0186] Take the medicinal material of Dendrobium nobile, crush it into coarse powder, add 95% ethanol to reflux and extract 3 times, recover the ethanol until it has no alcohol smell, adjust the pH to 3-4 with hydrochloric acid, filter, and adjust the pH of the filtrate to 10 with 10% ammonia water, Then extract with appropriate amount of chloroform for 8 times, collect the chloroform layer, recycle the chloroform, and dry to obtain the total alkaloids of Dendrobium nobile; wherein the content of lipophilic total alkaloids is 68%.

Embodiment 2

[0187] Embodiment 2 of the present invention: the extraction of total alkaloids of Dendrobium nobile:

[0188] Take the medicinal material of Dendrobium nobile, crush it into coarse powder, add ethanol to extract 3 times, recover the ethanol until it has no alcohol smell, adjust the pH to 3-4 with hydrochloric acid, filter, adjust the pH of the filtrate to 10 with sodium hydroxide solution, and then use an appropriate amount of Extract 5-6 times with chloroform, collect the chloroform layer, recycle the chloroform, and dry to obtain the total alkaloids of Dendrobium nobile, wherein the content of lipophilic total alkaloids is 62%.

Embodiment 3

[0189] Embodiment 3 of the present invention: the application of total alkaloids of Dendrobium nobile:

[0190] Get 50-2000 mg of Dendrobium nobile total alkaloid extract, 0.1-0.40 mg of magnesium stearate, 4-12 mg of sodium carboxymethyl starch, and 50-100 mg of microcrystalline cellulose obtained in Example 1, and extract The product is mixed with sodium carboxymethyl starch and microcrystalline cellulose, sieved, mixed evenly, added an appropriate amount of water or ethanol to granulate, after drying, granulated, added magnesium stearate, and then pressed the granules with a punching device into Tablets, which are tablets for treating ischemic brain injury. The tablet is taken orally, 3 times a day, 1-3 tablets each time.

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Abstract

The invention discloses applications of dendrobium nobile lindl alkaloids (DNLA) in medicines prepared for treating ischemic brain damage and a product thereof. The DNLA is lipophilic total alkaloids composition which is extracted from the dendrobium nobile lindl. Compared with the prior art, the invention aims at the nosogenesis of stroke, studies the protection function of the DNLA on oxygen-glucose deprivation injury model of primary cortical neurons and acute cerebral ischemia model of rats, analyzes the mechanism, further makes clear the pharmacological action and mechanism action of the DNLA for treating cerebral ischemia, and provides pharmacological basis for the development and applications of the dendrobium nobile lindl medical material.

Description

Technical field: [0001] The invention relates to the application and product of total biological alkaloids of Dendrobium nobile in the preparation of medicines for treating ischemic brain injury, and belongs to the technical field of traditional Chinese medicines. Background technique: [0002] Cerebrovascular disease is a common and frequently-occurring disease of the nervous system, which seriously endangers human health. Stroke is a serious type of cerebrovascular disease, with an average annual incidence rate of 124 / 100,000-388 / 100,000 males and 61 / 100,000-312 / 100,000 females, with extremely high disability and mortality rates . In recent years, the mortality rate of cerebral apoplexy in my country has decreased, but the incidence rate is on the rise, and it is getting younger day by day. Nearly 25% of stroke occurs before the age of 65, especially in patients with cerebral infarction under the age of 40. The incidence rate is 6% higher than that of 5 years ago. times. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61P9/10A61P25/00A61K135/00
Inventor 石京山
Owner ZUNYI MEDICAL UNIVERSITY
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