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Desorption ionization device used in mass spectrometer

A mass spectrometer and desorption technology, applied in the field of mass spectrometry, to achieve the effects of improving compatibility, improving ionization efficiency, and improving ionization effect

Active Publication Date: 2009-09-02
SHIMADZU RES LAB SHANGHAI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In this method, since the laser is used as the desorption source, the desorption area of ​​the sample surface is well controlled, which makes it possible to characterize the mass spectrometer image under normal pressure.

Method used

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  • Desorption ionization device used in mass spectrometer
  • Desorption ionization device used in mass spectrometer

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Embodiment Construction

[0025] The invention is applicable to the ionization of analyte samples attached to various solid surfaces. In a preferred embodiment of the present invention, the ionization process in the test can be completed by laser desorption photoionization, or by simultaneously performing photoionization and electrospray ionization on the desorbed analyte molecules, and the latter can reach the maximum The purpose of ionizing the individual components of a mixture to a greater extent.

[0026] Please refer to figure 1 as shown, figure 1 It is a schematic diagram of a desorption ionization device in a preferred embodiment of the present invention. The laser used for desorbing the sample to be measured is, for example, a semiconductor infrared laser 5 , whose wavelength range is preferably between 800-1200 nm. Lasers are usually operated in continuous wave mode, but can also be operated in pulsed mode using fast power switching if necessary. After leaving the laser 5, the laser beam ...

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Abstract

The invention relates to a desorption ionization device which carries out desorption to a measured object with a solid surface at atmospheric pressure by laser and then carries out ionization to the object after desorption by utilizing vacuum-ultraviolet light. The device comprises a laser generating laser beams, an optical laser system used for converging the laser beams on the surface of the measured object so as to lead the measured object in the sample to be desorbed or gasified, and an ultraviolet lamp which is arranged near the desorbed or gasified part and gives off ultraviolet rays soas to lead molecules of at least one part of the desorbed or gasified object to be ionized. Being combined with a spraying apparatus, the desorption ionization device has higher ionization efficiencyto nonpolar or low-polar micromolecules. The desorption ionization device can be applicable to fast sync analysis of complex mixtures with different polarities and molecular weights by utilizing vacuum-ultraviolet light / electron spray. Meanwhile, the design of the multichannel chamber structural keeps the local concentration of each component in an ion source effectively when a test is carried out, thereby improving the ionization efficiency.

Description

technical field [0001] The invention relates to the mass spectrometry technology at normal temperature and pressure, in particular to a desorption ionization device for a mass spectrometer that desorbs and ionizes analytes under normal pressure to be introduced for mass analysis. Background technique [0002] With the increasing application of mass spectrometry in the fields of scientific research, production and environmental monitoring, how to directly ionize the analyte under normal temperature and pressure and introduce it into a mass spectrometer working under vacuum conditions for analysis has become the most important thing for people. One of the topics of interest. [0003] The emergence of electrospray ionization (ESI) and atmospheric pressure matrix-assisted laser desorption ionization (AP-MALDI) respectively solved the problem of normal pressure ionization in liquid phase and solid phase. Mixed matrix, which caused great difficulties for the direct and rapid anal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/64H01J49/26
Inventor 丁力孙文剑
Owner SHIMADZU RES LAB SHANGHAI
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