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Chinese medicinal composition for treating headache, preparation method and quality control method thereof

A quality control method and composition technology, which are applied in the field of pharmaceutical compositions, traditional Chinese medicine compositions for treating headaches and their preparation fields, can solve problems such as poor tolerance, and achieve the effect of ensuring safety

Active Publication Date: 2009-08-26
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, taking these drugs for a long time will not only cause addiction, but also have poor tolerance, which cannot fundamentally solve the patient's headache problem

Method used

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  • Chinese medicinal composition for treating headache, preparation method and quality control method thereof
  • Chinese medicinal composition for treating headache, preparation method and quality control method thereof
  • Chinese medicinal composition for treating headache, preparation method and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 2

[0089] Experimental example 2 Quality inspection method test research

[0090] 1. TLC identification of Rhizoma Chuanxiong

[0091] (1) preparation of need testing solution and reference substance solution

[0092] Get 20 tablets of the preparation prepared according to Example 1 in four parts, remove the sugar coating, grind finely, add 30 ml of ether for ultrasonic treatment, filter, evaporate the filtrate to dryness, add 1 ml of ethanol to the residue to dissolve, and use it as the test solution.

[0093] Four parts of 1 g of Chuanxiong reference drug were taken, 30 ml of ethanol was added for ultrasonic treatment, filtered, the filtrate was evaporated to dryness, and the residue was dissolved with 1 ml of ethanol as the reference drug solution.

[0094] According to the preparation method of Example 1, a negative sample lacking Rhizoma Chuanxiong was prepared, and then a negative control solution was prepared according to the preparation method of the test solution.

[0...

Embodiment 1

[0208] Horn 1400g, Rhizoma Chuanxiong 250g, Angelica dahurica 450g, Aconitum 150g, Uncaria 200g

[0209] Pound slices of croissants, decoct twice with water, add 8 times the amount of water for the first time and cook for 3 hours, add 6 times the amount of water for the second time and cook for 3 hours, filter in several times, combine the filtrates, and concentrate to a thick paste of 1.35 (50°C); the rest of Ligusticum chuanxiong etc. are crushed to 24 orders, according to the percolation method under the liquid extract and extract item, with 30% ethanol as solvent, percolation is carried out at a speed of 150ml / min*kg, until the liquid is completely dry. Until the color or no alkaloid reaction, collect the filtrate, recover ethanol, concentrate to 1.35 thick paste (50°C), mix with croissant and 100g dextrin, granulate, dry, press into 1000 tablets, and coat with sugar, that is have to.

Embodiment 2

[0211] 1400g croissant, 250g Chuanxiong, 450g Angelica dahurica, 150g Chuanwu

[0212] Pound slices of croissants, decoct twice with water, add 8 times the amount of water for the first time and cook for 3 hours, add 6 times the amount of water for the second time and cook for 3 hours, filter in several times, combine the filtrates, and concentrate to a thick paste of 1.35 (50°C); the rest of Ligusticum chuanxiong etc. are crushed to 24 orders, according to the percolation method under the liquid extract and extract item, with 30% ethanol as solvent, percolation is carried out at a speed of 150ml / min*kg, until the liquid is completely dry. Until the color or no alkaloid reaction, collect the filtrate, recover ethanol, concentrate to 1.35 thick paste (50 ℃), mix with croissant and 116g dextrin, granulate, dry, press into 1000 tablets, and coat with sugar, that is have to.

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Abstract

The invention provides a Chinese medicinal composition for treating headache, as well as a preparation method and a quality control method thereof. The Chinese medicinal composition consists of sheep horns, hemlock parsley, angelica dahurica, processed radix aconiti, uncaria and other raw medicinal materials, and can be added with auxiliary materials according to the conventional process and prepared into tablets, capsules, oral liquid preparations, dropping pills, soft capsules, granules and other clinically acceptable preparation forms. The method for controlling the quality of the Chinese medicinal composition comprises the steps of performing qualitative inspection on the hemlock parsley and the angelica dahurica, performing qualitative limit inspection on the aconitine, performing quantitative determination on alcohol-soluble extract, detecting nitrogen content and performing quantitative determination on the ferulic acid. The Chinese medicinal composition has remarkable effect of treating headache.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a traditional Chinese medicine composition for treating headache, a preparation method and a quality control method thereof, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Headache is a clinically common disease, and currently the main symptoms of headache can be found in infectious febrile diseases, hypertension, intracranial disorders, neurosis, concussion and migraine and other diseases. [0003] Headaches can occur in those who suffer from exogenous six evils, internal injury to viscera, blockage of yang qi, upward sawing of turbid evil, hyperactivity of liver yang, loss of essence qi and blood, and abnormal operation of meridians. According to the etiology, headache can be divided into exogenous pathogenic factor and internal injury. Headache due to exogenous pathogenic factors, such as common cold, wind-heat, rheumatism, sum...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61K36/74A61K9/28A61P25/04G01N30/90G01N30/36A61K35/32
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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