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Degradable esophagus tubular intervention support and preparation method thereof

A tubular and esophageal technology, applied in stents, medical science, prostheses, etc., can solve problems such as small adjustment range, insufficient radial support force of stents, and poor fluid flow performance

Inactive Publication Date: 2009-08-26
中国人民解放军总医院第二附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some defects in the stents. For example, the commonly used stents are mostly braided with wire, which is in the shape of a tubular grid. Such stents have overlapping points, which makes the fluidity of the liquid worse, and the radial support of the stent is insufficient, which can The range of adjustment is small

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1) Prepare a hollow tube with an outer diameter of 1 to 100 mm and a tube wall of 0.05 to 10 mm by using polyε-caprolactone and paclitaxel at a mass ratio of 1000:1;

[0026] 2) Hollow out the outer wall of the hollow tube by etching to make it a grid-shaped tubular stent;

[0027] 3) immerse the tubular stent in an acetic acid solution containing 2wt% chitosan and 5wt% X-ray developer, then take it out and dry it;

[0028] 4) The prepared tubular stent is heated at 50-150° C. for 2-8 hours and then taken out to obtain a degradable stent containing the drug paclitaxel and X-ray contrast agent.

[0029] 5) The prepared stent can be deformed under external force, the radial length can be 1.5 times the original size, and the diameter can be reduced to 1 / 4 of the original; through in vitro measurement, it is found that the paclitaxel drug in the stent reaches 80% within 4 weeks Release amount, all medicines release completely within 5 weeks.

Embodiment 2

[0031] 1) preparing polyε-caprolactone and paclitaxel according to a mass ratio of 1000:1 to prepare a hollow tube with an outer diameter of 1-100 mm and a tube wall of 0.05-10 mm;

[0032] 2) Hollow out the outer wall of the hollow tube by engraving to make it a tubular stent with a zigzag pattern;

[0033] 3) immerse the tubular stent in an acetic acid solution containing 2wt% chitosan and 5wt% X-ray developer, then take it out and dry it;

[0034] 4) The prepared tubular stent is heated at 50-150° C. for 2-8 hours and then taken out to obtain a degradable stent containing the drug paclitaxel and X-ray contrast agent.

[0035] 5) The prepared stent can be deformed under external force, the radial length can be 1.5 times the original size, and the diameter is reduced to 1 / 5 of the original; through in vitro measurement, it is found that the paclitaxel drug in the stent reaches 75% within 4 weeks The amount of release, all drugs are released completely within 6 weeks.

Embodiment 3

[0037] 1) preparing a hollow tube with an outer diameter of 1 to 100 mm and a tube wall of 0.05 to 10 mm by using gelatin, polyethylene glycol and X-ray developer;

[0038] 2) Hollow out the outer wall of the hollow tube by molding to make it a tubular stent with a sinusoidal pattern;

[0039] 3) immerse the tubular support in an acetic acid solution containing 2wt% chitosan and 0.05wt% cyclosporin, then take it out and dry it;

[0040] 4) The prepared tubular stent is heated at 50-150° C. for 2-8 hours and then taken out to obtain a degradable stent containing a drug coating and an X-ray contrast agent.

[0041]5) The prepared stent can be deformed under external force, the radial length can be 1.5 times the original size, and the diameter can be reduced to 1 / 4 of the original; through in vitro measurement, it is found that the cyclosporin drug in the stent can be reduced within 5 weeks. Reach 80% release amount, all medicines release completely within 7 weeks.

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Abstract

The invention relates to a degradable esophagus tubular intervention support which is characterized in that the degradable esophagus tubular intervention support is a tubular intervention support with various patterns obtained by hollowing out outer wall of a hollow tube made of mixture of degradable macromolecular material and medicament or X-ray developer, external diameter of the hollow tube is 1-100 millimeters, thickness of the tube wall is 0.05-10 millimeters, and medicament film or X-ray developer is coated on the tube wall of the degradable tubular intervention support.

Description

technical field [0001] The invention relates to a degradable esophageal tubular interventional stent and a preparation method thereof, belonging to the field of medical devices, and the prepared degradable esophageal tubular interventional stent is mainly used in the clinical treatment of various diseases of digestive tract stenosis (including malignant stenosis and benign stenosis) , At present, there is no research and development and application of similar products at home and abroad. Background technique [0002] Interventional therapy specifically refers to the use of medical imaging equipment such as X-ray fluoroscopy, CT positioning, and B-type ultrasound equipment as guidance, and the special catheter or device is passed through the human artery, vein, natural duct of the digestive system, biliary tract or drainage duct after surgery. In the diseased area in the body, obtain tissue cells, bacteria or biochemical data, and perform imaging data to obtain imaging data, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/82A61L27/36A61L27/54A61L27/26A61L27/22A61L27/18A61L27/20
Inventor 李楠齐宏旭王雪明王艳翟俊山朱建华
Owner 中国人民解放军总医院第二附属医院
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