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'Relingqing' chewable tablet and preparation method thereof

A chewable tablet, hot drenching technology, applied in the field of medicine, can solve the problems of personal privacy impact, decreased stability, increased hygroscopicity, etc., and achieves the effects of high bioavailability, convenient administration, and fast release speed.

Inactive Publication Date: 2009-08-05
孙向阳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Relinqing granules have been widely used, there are still some defects: the taste of sugar-free Relinqing granules is bitter and the taste is poor; Sucrose has increased hygroscopicity and decreased stability, and because of the addition of sucrose, if it is used for diabetic patients with urinary tract infection, it will cause an increase in blood sugar; it is inconvenient to swallow, and it needs to be taken with boiled water when taking it, so that in some occasions It is critical to take the medicine next time, such as taking it when there is no boiling water during the trip, and taking medicine on some important occasions will affect personal privacy

Method used

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  • 'Relingqing' chewable tablet and preparation method thereof
  • 'Relingqing' chewable tablet and preparation method thereof
  • 'Relingqing' chewable tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] 1. Prescription

[0064]

[0065] 2. Preparation method:

[0066] Take 3300g of Polygonum japonica medicinal materials, add water to decoct twice for 1.5 hours each time, combine the decoctions, filter, and concentrate the filtrate under reduced pressure to a thick paste with a relative density of 1.35-1.38 (60°C), vacuum dry, and pulverize into fine Powder, add mannitol 180g, sorbitol 180g, steviol 5g, citric acid 10g, mix well, granulate with 80% ethanol, dry at low temperature (60°C), add magnesium stearate, mix well, and press into 0.7g The finished tablet of the present invention can be obtained as the finished product of the hot shower clear chewable tablet, and the tablet can also be coated with a film coating as required. Measured by HPLC, each Relinqing chewable tablet contains Polygonum capsulata to quercetin (C 15 H 10 O 7 ·H 2 O), it is 1.12 mg.

Embodiment 2

[0068] 1. Prescription

[0069]

[0070] 2. Preparation method: refer to Example 1. Measured by HPLC, each Relinqing chewable tablet contains Polygonum capsulata to quercetin (C 15 H 10 O 7 ·H 2 O), it is 1.03mg.

Embodiment 3

[0072] 1. Prescription

[0073]

[0074] 2. Preparation method: refer to Example 1. Measured by HPLC, each Relinqing chewable tablet contains Polygonum capsulata to quercetin (C 15 H 10 O 7 ·H 2 O), it is 1.27mg.

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Abstract

The invention belongs to the technical field of medicine, and discloses a Relinqing chewable tablet and a preparation method thereof. The Relinqing chewable tablet is prepared from polygonum capitatum, mannitol, D-sorbitol sorbitol, stevioside, citric acid, magnesium stearate and ethanol. The preparation method comprises: taking a polygonum capitatum crude medicine, and adding water into the polygonum capitatum crude medicine for decoction for two times, wherein the decoction is performed for 1 to 2 hours each time and 12 to 14 times of water is added each time; mixing decoction solution, filtering the mixture, and performing vacuum concentration on filtrate to obtain dense ointment with the relative density of between 1.35 and 1.38 (60 DEG C); drying the dense ointment, and crushing the obtained product into fine powder; adding the mannitol, the D-sorbitol sorbitol, the stevioside and the citric acid into the fine powder, and uniformly mixing the materials; adding the ethanol as an adhesive to prepare particles; and adding the magnesium stearate to press the particles into tablets, and encapsulating film coats to obtain the Relinqing chewable tablet. As calculated by quercetin, the weight of the polygonum capitatum in each tablet is required to be not less than 0.1 milligram. The Relinqing chewable tablet has the advantages of good mouthfeel, quick medicine release, convenient taking, convenient carrying, stable quality, simple process and easy industrial production on a large scale.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a Relinqing chewable tablet and a preparation method thereof. 2. Background technology [0002] Urinary tract infection is the main infectious disease of the genitourinary system, divided into simple urinary tract infection and complicated urinary tract infection. Simple urinary tract infection is not associated with risk factors, and most of them can be cured with simple treatment. Complicated urinary tract infection is usually accompanied by urinary calculus, urinary tract obstruction, nephrocalcinosis, polycystic kidney disease, bladder and ureteral reflux, or neurogenic bladder. In addition, pregnancy, diabetes, kidney transplantation, metabolic and immune Diseases, etc. can be complicated by complicated urinary tract infection. Recurrent or persistent complicated urinary tract infections can accelerate and aggravate renal damage, leading to renal insufficie...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61K9/28A61K47/12A61P13/00
Inventor 黄振华
Owner 孙向阳
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