Liquid external preparation for preparing total alkaloids in nux vomica

Abstract

The invention relates to a preparation formulation for an externally applied liquid preparation prepared from total strychnos alkaloids, and preparation thereof. The preparation formulation is prepared from the total strychnos alkaloids and auxiliary materials such as a transdermal sorbefacient, a solvent, a humectant and an antiseptic according to certain proportion. The externally applied liquid preparation of the total strychnos alkaloids comprises a pharmaceutically described externally applied liquid preparation such as a spraying agent, a wet application, a liniment or a pigmentum, and is used for treating diseases such as injuries from falls, carbuncle-abscess pain, rheumatic obstinate paralysis, rheumatoid arthralgia and anesthesia and paralysis. The preparation can overcome the defect that people are easy to be poisoned when orally taking strychnos. As proved by research results, the preparation is safe and effective, is convenient and comfortable to use, has small skin irritation and low production cost, is easy to be accepted by patients, and can generate good social benefit and economic benefit.

Description

technical field [0001] The invention relates to a liquid external preparation prepared from total alkaloids of strychnium. Background technique [0002] Nuxychia is a species recorded in the 2005 edition of the Pharmacopoeia. Its nature and flavor are bitter, cold, and highly toxic. It returns to the liver and spleen meridian. Swelling and pain, rheumatic paralysis, rheumatoid joint pain, numbness and paralysis and other diseases. Strychnine containing strychnine, strychnine, strychnine, strychnine, pseudo strychnine, pseudo strychnine, 4-hydroxy strychnine, strychnine Nitrogen oxides, strychnine nitrogen oxides, ecaine, 4-hydroxy 3-methyl strychnine and other alkaloids, in addition, it also contains fatty oil, protein, chlorogenic acid, strychnine, etc. . The main active ingredients are strychnine and strychnine, and the Pharmacopoeia stipulates that the content of strychnine in the strychnine is 1.2-2.2%, and the content of strychnine is not less than 0.8%. Nuxychia sh...

AI Technical Summary

Problems solved by technology

Guo Liwei and others reported that the total alkaloids of Nuxebra chinensis were made into a film-coating agent, but the stability of the preparation was only studied for two weeks, and slight stratification had occurred within two weeks, and many operational factors would affect the preparation process. The quality of the preparation is not suitable for industrialized large-scale production

In addition, many documents have reported the in vitro absorption, analgesic and anti-inflammatory studies of strychnine and strychnine liposomes. Numerous alkaloids contained in Semen strychnine have strong pharmacological effects. Strychnine is not conducive to maintaining the original clinical efficacy of strychnine, and its toxic and side effects may increase with the increase of strychnine concentration

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