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Traditional Chinese medicine formulation granules containing volatile oil and preparation method thereof

A technology of traditional Chinese medicine formula granules and formula granules, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, and non-active ingredients of polymer compounds. It can solve the problems of no volatile oil, low extraction efficiency, and less volatile oil, and achieve improvement Product quality and stability, high concentration of active ingredients, enhanced stability effect

Active Publication Date: 2009-07-29
BEIJING KANGRENTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many manufacturers do not consider the actual situation in the production process, and extract volatile oil when they see varieties containing volatile oil; some manufacturers do not extract volatile oil when they should extract volatile oil in order to save costs, resulting in confusion in product quality and even potential safety hazards
[0007] 2. The amount of volatile oil added to the formula granules of different manufacturers varies greatly, and even the amount of volatile oil added between different production batches of the same manufacturer also varies a lot. In the production process, it is often how much volatile oil is extracted and how much is added For volatile oil, a certain batch of raw materials has high oil content, if the oil is fully extracted, the product will have high volatile oil content; if the raw material has low oil content, and the extraction efficiency is low, the product will contain less volatile oil, or even almost no volatile oil

Method used

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  • Traditional Chinese medicine formulation granules containing volatile oil and preparation method thereof
  • Traditional Chinese medicine formulation granules containing volatile oil and preparation method thereof
  • Traditional Chinese medicine formulation granules containing volatile oil and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] Embodiment 1: Preparation of asarum formula granules

[0110] Take Asarum 100kg, pick out impurities, and chop; soak the clean and broken Asarum with 2 times the weight of water for 40 minutes; extract volatile oil with straight-through steam for 3 hours, and collect 0.185kg of volatile oil; add water to the material after extracting volatile oil 5 times by weight, heated and refluxed twice for 2 hours each time; the extract was concentrated under reduced pressure at a vacuum of 0.06 MPa to a relative density of 1.15 to obtain an extraction concentrate; 10 times by weight of β-cyclo Dextrin, 60 times of purified water by weight, use colloid mill grinding method to carry out inclusion of volatile oil, colloid mill slit gap 5-10 micron, grind for 20 minutes, get volatile oil β-cyclodextrin inclusion complex; volatile oil β- Mix the cyclodextrin inclusion compound and the extract concentrate evenly, adjust the relative density to 1.1, preheat to 50°C, and spray dry. The sp...

Embodiment 2

[0111] Embodiment 2: the preparation of grass nut formula granules

[0112] Take 100 kg of grass nuts, pick out impurities, and break them; soak the clean and broken grass nuts with 3 times the weight of water for 50 minutes; extract volatile oil for 10 hours by direct steam method, and collect 0.100 kg of volatile oil; extract the volatile oil Add 10 times the weight of water to the material, heat and reflux and extract 3 times, each time for 3 hours; the extract is concentrated under reduced pressure at a vacuum of 0.07 MPa to a relative density of 1.05 to obtain an extraction concentrate; add 7 times the weight of β to the volatile oil. -Cyclodextrin, 45 times of purified water by weight, carry out the inclusion complex of volatile oil with colloid mill grinding method, colloid mill slit gap 5-10 microns, grind for 15 minutes, get volatile oil β-cyclodextrin inclusion complex; Mix the β-cyclodextrin inclusion compound and the extract concentrate evenly, adjust the relative ...

Embodiment 3

[0113] Embodiment 3: the preparation of Chuanjiao formula granules

[0114]Take 100kg of Sichuan pepper, pick out impurities, and chop it; soak the clean and broken Sichuan pepper with 2 times the weight of water for 40 minutes; extract the volatile oil for 3 hours with the direct steam method, and collect 0.141kg of the volatile oil; add water to the material after extracting the volatile oil 5 times by weight, heated and refluxed for 2 times, each time for 2 hours; the extract was concentrated under reduced pressure at a vacuum of 0.08MPa to a relative density of 1.15 to obtain an extraction concentrate; 7 times by weight of β-ring was added to the volatile oil Dextrin, 65 times of purified water by weight, use colloid mill grinding method to carry out inclusion of volatile oil, colloid mill slit gap 5-10 micron, grind for 20 minutes, get volatile oil β-cyclodextrin inclusion complex; volatile oil β- Mix the cyclodextrin inclusion compound and the extract concentrate evenly,...

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Abstract

The invention discloses a traditional Chinese medicine formulation granule containing volatile oil composition and a preparation method thereof. In the preparing process of the traditional Chinese medicine formulation granule, a traditional Chinese medicine containing the volatile oil as an effective ingredient is selected to prepare the traditional Chinese formulation granule by immersing, quantitatively extracting the volatile oil, including by beta-cyclodextrin, extracting by water, decompressing and concentrating, spray drying and the other steps. The traditional Chinese medicine formulation granule not only sufficiently ensures drug effect, but also can avoid over violent drug property or adverse effect caused by over dosage of the volatile oil to ensure the safety of the granule; and by quantitatively collecting and adding the volatile oil, wherein the collecting amount of the volatile oil is equivalent to the dosage of the volatile oil in decoction. The preparation process improves the quality and stability of products, has high concentration of drug effective ingredient of the products, and is convenient for transportation, storage, portability and taking.

Description

technical field [0001] The invention relates to traditional Chinese medicine formula granules and a preparation method thereof, in particular to a class of traditional Chinese medicine formula grains containing volatile oil components and a preparation method thereof. Background technique [0002] Traditional Chinese medicine formula granules, under the guidance of the theory of traditional Chinese medicine, use standard processed traditional Chinese medicine decoction pieces as raw materials, and use extraction, low-temperature concentration, spray drying, dry granulation and other techniques to process them into ingredients equivalent to traditional Chinese medicine decoction pieces, for doctors to prescribe Granules used or used as raw materials for preparations. Compared with traditional Chinese medicine decoctions, the formula granules are convenient to take, the dosage is small, the quality is controllable, easy to store, and easy to carry. At present, the product is ...

Claims

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Application Information

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IPC IPC(8): A61K36/00A61K9/16A61K47/40
Inventor 吴玢付静张翠
Owner BEIJING KANGRENTANG PHARMA
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