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Erigeron breviscapus eye-preparation and preparation method thereof

A technology of breviscapine and asarum eye, which is applied in the field of breviscapine ophthalmic preparation and preparation thereof, can solve the problem that the bioavailability cannot be effectively improved, the application and report of eye medicines are not seen, and the product development technology content is low. and other problems to achieve the effect of improving bioavailability, improving curative effect and increasing stability

Active Publication Date: 2009-07-29
YUNNAN PHYTOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Erigeron breviscapus is a kind of botanical medicine. The existing preparations include oral preparations and injections. The existing products still have the following shortcomings: the problem of water solubility is not solved; the technical content of product development is low, and its bioavailability cannot be effectively improved
[0005] Escutellarin is a new effective part isolated from Escutellaria breviscapine, and there is no application or report of using scutellarin to prepare ophthalmic drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] To prepare scutellarin eye drops:

[0065] Take 15Kg of water for injection, add sodium chloride 0.05Kg, boric acid 0.24Kg, borax 0.03Kg, Nepal gold ethyl ester 0.006Kg, sodium sulfite 0.02Kg, EDTA 0.02Kg, stir to dissolve, then add scutellarin 0.02Kg, stir to make Dissolve it, adjust the pH to 7.2, add water to a total of 20 kg, filter the above solution through a 0.22 μm microporous membrane, aseptically dispense it into eye drop bottles, and pack it.

Embodiment 2

[0067] To prepare scutellarin eye drops:

[0068] Take 15Kg of water for injection, add sodium chloride 0.08Kg, sodium dihydrogen phosphate 0.032Kg, disodium hydrogen phosphate 0.15Kg, phenylethyl alcohol 0.02Kg, sodium sulfite 0.02Kg, EDTA 0.02Kg, stir to dissolve, add scutellarin 0.6 Kg, stir to make it dissolve, add water to a total of 20kg, filter the above solution through a 0.22 μm microporous membrane, aseptically dispense it into eye drop bottles, and pack it.

Embodiment 3

[0070] To prepare scutellarin eye drops:

[0071] Take 15Kg of water for injection, add sodium chloride 0.08Kg, sodium dihydrogen phosphate 0.032Kg, disodium hydrogen phosphate 0.15Kg, phenylethyl alcohol 0.02Kg, sodium sulfite 0.02Kg, EDTA 0.02Kg, stir to dissolve, add scutellarin 3.0 Kg, stir to make it dissolve, add water to a total of 20kg, filter the above solution through a 0.22 μm microporous membrane, aseptically dispense it into eye drop bottles, and pack it.

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PUM

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Abstract

The invention discloses an erigeron phenol ophthalmic preparation and a preparation method thereof. The ophthalmic preparation comprises an eye drop, an ophthalmic liposome, an inclusion complex eye drop, an eye ointment, ophthalmic in situ-gel, and the like. The ophthalmic preparation is prepared by taking erigeron phenol as an active effective constituent and adding pharmaceutical expicients of the ophthalmic preparation, and the like, the weight percentage of the contained erigeron phenol is between 0.1 and 30 percent, and the balance is the pharmaceutical expicients of the ophthalmic preparation. The erigeron phenol is applied to the ophthalmic preparation, and has the advantages that compared with the prior erigeron whole-grass extract preparation, the erigeron phenol dispels impurities, has high purity of the active effective constituent, and can meet the need of the preparation of the ophthalmic preparation, when prepared into the ophthalmic preparation, the erigeron phenol increases the effective absorption of a medicine improves the bioavailability of the medicine, and increases the stability of the preparation. The ophthalmic preparation has better application prospect to the prevention and treatment of ophthalmic diseases, particularly the treatment of glaucoma disease.

Description

technical field [0001] The invention relates to a medicine for treating ophthalmic diseases, in particular to a scutellarin ophthalmic preparation and a preparation method thereof. Background technique [0002] Erigeron breviscapus, also known as Erigeron breviscapus (Vanr) Hand-Mazz., is abundant in Yunnan Province of my country. It is the dry whole herb of Erigeron breviscapus (Vanr) Hand-Mazz. Scutellarin is a new effective part isolated from scutellaria in recent years, and its patent CN 1462620A is the preparation of scutellarin and the preparation method of oral preparations and injections; [0003] Glaucoma is the second most serious blinding eye disease after cataract, with a prevalence rate of 0.4-1.68% and a blindness rate of 9.26%. Currently, there are about 7 million patients in the world. Zhu Yihua et al. used Erigeron breviscapus intraperitoneal injection to treat acute ocular hypertension model rats, and the results showed that it could improve the axoplasmic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7024A61K36/28A61P9/10A61P25/28A61P3/06
Inventor 郭文严家定朱丽萍
Owner YUNNAN PHYTOPHARML
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