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Aqueous solution containing coenzyme Q10 nano granule and preparation method thereof

A nanoparticle and aqueous solution technology, which is applied in the direction of medical preparations containing active ingredients, medical preparations with non-active ingredients, and pharmaceutical formulas, etc. It can solve the problems of unstable preparations, redox duality, and unstable physical and chemical properties.

Active Publication Date: 2009-07-22
SHENZHOU BIOLOGY & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The object of the present invention is to provide a 10 Aqueous solution of nanoparticles and preparation method thereof, solving the problem of coenzyme Q 10 The physical and chemical properties are unstable, and there is redox duality, which leads to coenzyme Q 10 The preparation is very unstable

Method used

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  • Aqueous solution containing coenzyme Q10 nano granule and preparation method thereof
  • Aqueous solution containing coenzyme Q10 nano granule and preparation method thereof
  • Aqueous solution containing coenzyme Q10 nano granule and preparation method thereof

Examples

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Effect test

Embodiment 1

[0039] coenzyme Q 10 4g, HP-β-cyclodextrin 30g, γ-cyclodextrin 6g, hydroxypropyl methylcellulose 3g, purified water 100ml.

[0040] Put cyclodextrin, Tween 80 and hydroxypropyl methylcellulose in 100ml of purified water in the prescription, stir until dissolved, and place in a water bath at 50°C. Prescription Amount Coenzyme Q 10 Heat to dissolve, slowly add to the 60°C water phase solution under high-speed stirring, stir at 5000rpm for 5 minutes, put the material into a high-pressure homogenizer, and homogenize 3 times at 100Mpa. Add 2000ml of purified water, and then discharge the material such as a high-pressure homogenizer 100Mpa to homogenize twice to obtain a light yellow uniform emulsion as the final product.

Embodiment 2

[0042] coenzyme Q 10 3g, HP-β-cyclodextrin 10g, γ-cyclodextrin 20g, Tween 800.5g, sodium carboxymethylcellulose 3g, purified water 100ml.

[0043]Put cyclodextrin, Tween 80 and sodium carboxymethylcellulose in 100ml of purified water in the prescription, stir until dissolved, and place in a 70°C water bath. Prescription Amount Coenzyme Q 10 Heat to dissolve, slowly add to the 70°C water phase solution under high-speed stirring, stir at 9000rpm for 10 minutes, put the material into a high-pressure homogenizer, and homogenize 3 times at 100Mpa. Put the material into the spray dryer, the air inlet temperature is 1220°C, the outlet air temperature is controlled at 115°C, and the light yellow powder is obtained as the final product.

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Abstract

The invention provides an aqueous solution containing coenzyme Q10 nano-particles, and a preparation method thereof, which belongs to the technical field of inclusion compounds and preparation thereof. The aqueous solution consists of coenzyme Q10, HP-beta cyclodextrin, gamma cyclodextrin and an emulsifier of which the weight ratio is 1:1-100:1-100:0.5-2. The preparation method adopts a process that the HP-beta cyclodextrin and the gamma cyclodextrin are weighed according to that the weight ratio of the coenzyme Q10 to the HP-beta cyclodextrin to the gamma cyclodextrin to the emulsifier is 1:1-100:1-100:0.5-2, are dissolved in water 3 to 10 times the weight of cyclodextrin and heated to be between 40 and 80 DEG C; an oil-phase matrix of the coenzyme Q10 is completely melted, added to an dissolved aqueous phase in a shearing state and shorn for 5 to 30 minutes at a speed of between 5,000 and 20,000 rpm; a solution obtained after shearing is sent into a high-pressure homogenizer and circulated twice to ten times under the pressure of between 50 and 200 MPa, so the liquid is obtained; and the liquid is diluted to a needed concentration under shearing conditions and continues to be homogenized and circulated once to ten times under the high pressure of between 50 and 220 MPa, so that a finished product is obtained. The preparation method has the advantages of greatly increasing the solubility of the coenzyme Q10 and improving the stability of the solution.

Description

technical field [0001] The invention relates to the technical field of clathrates and their preparation, and in particular provides a compound containing coenzyme Q 10 Aqueous solutions of nanoparticles and methods for their preparation. Background technique [0002] coenzyme Q 10 Also known as decene quinone, ubiquinone (ubiquinone), chemical name is 2,3-dimethoxy-5-methyl-6-decyl isopentenyl quinone, molecular formula is C 59 h 90 o 4 , with a relative molecular mass of 863.36, is a quinone compound widely present in animal livers, plant cells and microorganisms other than Gram-positive bacteria. CoQ in the cells of animals, plants, microorganisms, etc. 10 Combined with the inner membrane of mitochondria, it is a coenzyme that is not tightly bound to proteins in the respiratory chain. It functions as a particularly flexible carrier between flavoproteins and cytochromes, and is a hydrogen transferor in the electron transport chain. Necessary for the synthesis of ATP b...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/48A61K31/122A61P35/00A61P37/04A61P39/06A61K47/69
Inventor 王小雪庞欣张文龙石萌萌徐洁平
Owner SHENZHOU BIOLOGY & TECH CO LTD
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