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Application of theabrownin in pharmacy

A technology of theabrownin and theabrownin powder, applied in the field of theabrownin, can solve problems such as undiscovered, small toxic and side effects, and achieve the effects of no toxic and side effects, safe and reliable taking

Active Publication Date: 2009-07-08
PUER TEA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tea is a natural plant with less toxic and side effects. Theabrownin is one of the main active ingredients in tea, but so far there has been no report that theabrownin with a clear structure in tea inhibits PTP1B

Method used

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  • Application of theabrownin in pharmacy
  • Application of theabrownin in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Dried Pu-erh tea: water = 1:10-20 (W / V), boiled at 100°C for 10-30 minutes, filtered through a 120-mesh sieve to remove the residue, and collected the water extract. Repeat this step 2 to 4 times, and combine the extracts each time. The total extract was filtered through a 200-mesh sieve and a 0.45 μM filter, and then spray-dried at high temperature to obtain Pu'er tea powder.

Embodiment 2

[0038]Pu'er tea powder: water = 1:25 (W / V), to obtain an aqueous solution of tea powder, add an equal volume of chloroform to extract three times, collect and retain the aqueous phase, then extract three times with an equal volume of ethyl acetate, collect the aqueous phase, and finally use an equal volume of Extract with n-butanol and keep the aqueous phase. Evaporate and remove the water in the aqueous phase to obtain theabrownin powder.

Embodiment 3

[0040] Theabrownin was prepared into a stock solution of 5 mg / ml with distilled water, and diluted by a 2-fold gradient, and the inhibitory ability of each dilution concentration to PTP1B was determined, and the concentration of theabrownin (mg / ml) was used as the IC 50 units, measured in IC 50 0.0075mg / ml.

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Abstract

The invention discloses a new application of theabrownin in the pharmaceutical field. The theabrownin of the invention is a natural product which uses black tea or pu'er tea as a raw material and is extracted from the tea. The result of pharmacological experiments indicates that the theabrownin has the function of markedly restraining protein tyrosine phosphatase. The theabrownin can also be used for preventing or curing II type diabetes, fat diabetes and adiposis. As the theabrownin is the natural product extracted from the black tea or pu'er tea, thus enjoying the advantages of no toxicity and side effect, safe and reliable use.

Description

technical field [0001] The present invention relates to the application of theabrownin, in particular to the application in the field of pharmacy. Background technique [0002] Diabetes is a worldwide frequently-occurring disease. It is caused by insufficient insulin secretion by the body itself. Insulin is closely related to carbohydrate metabolism in the body. When the secretion of insulin in the body is insufficient, it will cause metabolic disorders of carbohydrates and other nutrients in the body, resulting in increased blood sugar and urine sugar and reduced glucose tolerance, resulting in polydipsia, polydipsia, etc. Phenomena such as overeating, polyuria, and weight loss will eventually lead to heart, kidney, brain and other multi-organ lesions. Due to factors such as population aging, unhealthy diet structure and obesity, it is estimated that by 2025, the number of diabetic patients worldwide will reach 300 million. [0003] Diabetes is clinically divided into tw...

Claims

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Application Information

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IPC IPC(8): A61K36/82A61P3/04A61P3/10A61K127/00
Inventor 盛军付学奇沈培平王亚军李婷陈颖丽赵昌能杨柳霞季爱兵李艳华
Owner PUER TEA RES INST
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