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Halometasone medicinal preparation and preparation method

A technology for pharmaceutical preparations and halometasone, which is applied in the directions of pharmaceutical combinations, pharmaceutical formulations, antifungal agents, etc., can solve the problems of prone to systemic reactions, slow onset of psoriasis, and short duration of action, and is convenient for large-scale industrial production. , adapt to the wide spectrum of diseases, the effect of small side effects

Inactive Publication Date: 2009-07-08
崔晓廷
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

External use of traditional Chinese medicine treats psoriasis with a slow onset of effect; clinical reports only use retinoids alone to treat psoriasis with an effective rate of about 50%, and most of the adverse reactions; effect, but it is easy to produce systemic reactions, the action time is short, the side effects are large, and it is easy to relapse after stopping the drug, so that most patients are not satisfied with the application of hormones in the treatment of psoriasis and the application of hormones in the treatment of dermatitis, eczema, vitiligo, hives, lupus erythematosus, flat Hormonal fears in diseases such as lichen, delaying treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Halometasone gel for dermatitis and eczema

[0020] prescription:

[0021] Halometasone 0.05%, Tween-800.005%, ethanol 10%, sodium carboxymethyl cellulose 3%, azone 2%, glycerin 25%, propylene glycol 10%, sodium hydroxide appropriate amount, and the balance is purified water.

[0022] Preparation method:

[0023] 1. Add halometasone micropowder into ethanol and Tween-80 aqueous solution and mix well to obtain A solution;

[0024] 2. Add appropriate amount of pure water to sodium carboxymethyl cellulose and stir to dissolve to obtain B solution;

[0025] 3. Add solution A to solution B under stirring, then add azone, glycerin, and propylene glycol in sequence, add the total amount with pure water, and stir well;

[0026] 4. Adjust the pH to 7-8 with sodium hydroxide. Subpackaging and quality inspection, you can get halometasone gel. Effect: This product is used for intractable dermatitis and eczema, and the effective rate reaches more than 95% within 1 week.

Embodiment 2

[0028] Compound Halometasone-Tazarotene Gel for Treating Psoriasis

[0029] prescription:

[0030] Halometasone 0.05%, Tazarotene 0.025%, Tween-800.005%, Ethanol 10%, Carmellose Sodium 3%, Azone 2%, Glycerin 25%, Propylene Glycol 10%, Sodium Hydroxide amount, I The amount is pure water.

[0031] Preparation method:

[0032] The preparation process is the same as in Example 1.

[0033] Effect:

[0034] The clinical curative effect is divided into four grades according to the degree of improvement of symptoms and signs. Basic recovery: the rash basically subsides, and the itching disappears; markedly effective: the rash subsides obviously, and the subjective symptoms of itching are obviously relieved; progress: the rash subsides, and the itching is relieved; ineffective: the rash subsides little or does not change. After 30-60 days of treatment, the total effective rate is 93%.

Embodiment 3

[0036] Halometasone Gel-Methoxysalen Tincture for Vitiligo

[0037] The prescription preparation method of halometasone gel is the same as embodiment 1.

[0038] How to make methoxsalen tincture:

[0039] prescription:

[0040] Methoxsalen 2g, 95% ethanol 10ml, azone 20ml, glycerin 30ml, propylene glycol 50ml, benzyl alcohol 1ml, pure water added to the total

[0041] Method;

[0042] Dissolve the prescribed amount of methoxsalen in ethanol, add azone, glycerin, propylene glycol, and benzyl alcohol in sequence, stir well, and add pure water to the total amount.

[0043] Instructions:

[0044] Wipe the affected area with methoxsalen solution every morning, once a day, and apply halometasone gel to the affected area every morning and evening, once each.

[0045] Efficacy: Taking 3 months as the evaluation period, the effective rate of treating localized vitiligo is 92%.

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PUM

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Abstract

The invention provides a single preparation and compound preparation using halometasone as main constituent. The weight ratio of halometasone in pharmaceuticals is 0.0001-50%. The pharmaceuticals can be made into jellies, supensoid agent, liquor and pulvis, and the like, which are administrated in a percutaneous way. The preparation is suitable for dermatitis, eczema, vitligo, psoriasis, hives, rhinitis, lupus sebaceous, lichen planus and asthma, etc. The invention has the advantages of high healing rate, high safety and high promotional value.

Description

technical field [0001] The invention is a pharmaceutical preparation, more specifically, relates to a halometasone pharmaceutical preparation and a preparation method, and belongs to the technical field of medicine and its preparation. Background technique [0002] Skin diseases are a large class of diseases that endanger human health, especially intractable skin diseases such as dermatitis, eczema, vitiligo, psoriasis, hives, lupus erythematosus, lichen planus, allergic upper respiratory diseases, etc. The longer the course of the disease, the more harmful it is. The pathogenesis of most of these diseases is not completely clear, protracted and refractory, and the recurrence rate is high. Bring great pain on the body to the patient, cause psychologically, economically heavy burden. [0003] The current treatment methods for this type of disease: oral Chinese and Western medicines, external drug administration, surgical treatment, physical therapy, etc. Although there are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61K45/00A61K47/38A61P11/02A61P11/06A61P19/04A61P17/00A61P17/06A61P31/10A61P37/02A61P37/08A61K36/904
Inventor 卢立娜
Owner 崔晓廷
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