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Brassiere paster for preventing and treating hyperplasia of mammary glands and preparation method thereof

A technology of mammary gland lobular hyperplasia and patch, applied in the field of medical supplies

Inactive Publication Date: 2009-07-01
SHANGHAI INST OF ONCOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on temperature-sensitive patches as matrix.

Method used

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  • Brassiere paster for preventing and treating hyperplasia of mammary glands and preparation method thereof
  • Brassiere paster for preventing and treating hyperplasia of mammary glands and preparation method thereof
  • Brassiere paster for preventing and treating hyperplasia of mammary glands and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1: prepare bra patch

[0039] 20g of gelatin, 200ml of distilled water, 45°C, heating and stirring until uniform thick liquid; dissolving 0.1g of far-infrared powder in 10ml of water, adding to the uniform gelatin solution; then adding 0.1ml of plant essential oil, fully stirring and mixing to form a milky liquid; 5 g of calf cartilage proteoliposomes were prepared and freeze-dried, the liposome freeze-dried powder was evenly mixed with the above-mentioned ingredients, and a bra patch was obtained after cooling.

Embodiment 2

[0040]Embodiment 2: Preparation of liposome suspension

[0041] Preparation of liposomes by reverse-phase evaporation method: 2 g of phospholipids was dissolved in chloroform, 45 ml of normal saline containing 200 mg of calf cartilage protein was added, an emulsion was formed by ultrasonication, ultrasonic power was 250 W, ultrasonic wave was 1 s, interval was 1 s, the whole process was 3 min, and transferred into a pear-shaped bottle , reduce the pressure and evaporate to form a colloidal state, add physiological saline, rotate to make the gel on the bottle wall fall off, and continue to evaporate under reduced pressure to obtain a liposome suspension.

Embodiment 3

[0042] Embodiment 3: preparation liposome

[0043] Dissolve 4 g of phospholipids in ether, transfer to a pear-shaped flask and rotate to evaporate to form a film on the inner wall of the flask, then dissolve 150 mg of calf cartilage protein in 34 ml of normal saline, add to the flask and stir continuously to obtain liposomes.

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PUM

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Abstract

The invention belongs to the field of medical products and relates to a bra patch preventing and treating hyperplasia of lobule of mammary glands, a preparation method thereof and use thereof. The patch is composed of calf gristle proteoliposome, substrates and penetration enhancers. The prepared bra patch can be further made into a far infrared fabric product of bra patch by adding a surface lining layer and a back lining layer. Experiments on animals show that the inventive bra patch and fabric product have no anaphylactic reaction and stimulation to skins and can well prevent and treat hyperplasia of lobule of mammary glands. The bra patch has advantages of a simple preparation flow, a low price, convenient use, nontraumatic treatment, good curative effect etc.

Description

Technical field: [0001] The invention belongs to the field of medical supplies, and relates to an external patch for preventing and treating breast lobular hyperplasia and its products, in particular to a bra patch made of pure natural materials and its preparation method and application. Background of the invention: [0002] Breast lobular hyperplasia is the most common breast disease, and it is the most common non-tumor, non-inflammatory hyperplastic lesion among breast hyperplasia diseases. Its incidence rate accounts for 80% to 90% of the female population, and can occur in women of any age after puberty. According to relevant statistics, its incidence rate accounts for the first place in breast diseases, and the incidence is on the rise in recent years, which seriously troubles patients. Work and life, studies have shown that breast lobular hyperplasia has a certain cancer rate. [0003] Clinical observation shows that most patients with breast lobular hyperplasia have...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K38/02A61K47/44A61K47/42A61P15/14A61K47/02
Inventor 段友容王维林薛建祥许金萍陈晓炎
Owner SHANGHAI INST OF ONCOLOGY
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