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Oxycodone controlled release tablets

A technology for controlled-release tablets and oxycodone, which is applied in the directions of pill delivery, organic active ingredients, non-active ingredients of polymer compounds, etc., can solve problems such as adverse reactions, coagulation disorders in the gastrointestinal tract, etc. Simple, high-quality effects

Inactive Publication Date: 2009-07-01
BEIJING HOPE HUGE PHARM SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no matter whether the dose of NSAIDs is increased or long-term application of small doses of NSAIDs, patients will suffer from coagulation dysfunction or gastrointestinal adverse reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: specification 1000 pieces

[0040] prescription:

[0041] Oxycodone 5 / 10 / 20 / 40g

[0042] Dextrin 300g

[0043]Polyethylene 300g

[0044] 70% pvp ethanol solution appropriate amount

[0045] Prescription of coating solution

[0046] Cellulose acetate 50g

[0047] Polysorbate-80 appropriate amount

[0048] Dibutyl phthalate Appropriate amount

[0049] Add 90% ethanol-acetone solution to 1000ml

[0050] Preparation method:

[0051] The oxycodone, dextrin and polyethylene are mixed evenly, granulated with 70% pvp ethanol solution, dried, granulated and compressed into tablets. Take cellulose acetate, appropriate amount of polysorbate-80, appropriate amount of dibutyl phthalate, dissolve with 1000ml of 90% ethanol-acetone mixed solvent to prepare coating solution. Coating until the weight of each coating layer is 8.5-9mg. Finished product inspection, coating.

Embodiment 2

[0052] Embodiment 2: specification 10000 pieces

[0053] prescription:

[0054] Oxycodone 400g

[0055] Dextrin 3000g

[0056] Polyethylene 3000g

[0057] 70% pvp ethanol solution appropriate amount

[0058] Prescription of coating solution

[0059] Cellulose acetate 500g

[0060] Polysorbate-80 amount

[0061] Dibutyl phthalate Appropriate amount

[0062] Add 90% ethanol-acetone solution to 10000ml

[0063] Preparation method:

[0064] The oxycodone, dextrin and polyethylene are mixed evenly, granulated with 70% pvp ethanol solution, dried, granulated and compressed into tablets. Take cellulose acetate, appropriate amount of polysorbate-80, appropriate amount of dibutyl phthalate, dissolve with 1000ml of 90% ethanol-acetone mixed solvent to prepare coating solution. Coating until the weight of each coating layer is 8.5-9mg. Finished product inspection, coating.

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PUM

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Abstract

The invention belongs to the technical field of medicament, disclosing an oxycodone controlled release tablet for easing durative moderate to severe pain. The characteristic of the novel formulation is that the invention is controlled release tablet which slowly and constantly or nearly constantly release medicament in water or determined releasing substrate.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to a dosage form of oxycodone, a pharmaceutical preparation for alleviating persistent moderate to severe pain and a preparation method thereof, in particular to a preparation method of oxycodone controlled-release tablets. Background technique [0002] According to a pain survey in Japan in 2004, there are approximately 17 million patients with chronic pain in Japan. Although 88% of pain patients expressed satisfaction with their doctors, only 23% of patients were satisfied with the degree of pain relief. In Japan, there is no general consensus that "pain is treatable" and there is no consensus among doctors that "pain must be treated". The results of a survey conducted by Professor Huang Yuguang in China four years ago are similar to this. In fact, not only in Asia, but also in the whole world, the same problem exists, that is, the pain is not well controlled. [0003] In recent...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K31/485A61K47/40A61P25/04
Inventor 王翰斌闫艳立吴广俣
Owner BEIJING HOPE HUGE PHARM SCI
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