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Xylitol intravenous injection liquid and preparation method thereof

An intravenous injection, xylitol technology, applied in pharmaceutical formulations, medical preparations with inactive ingredients, metabolic diseases, etc., can solve problems such as medical disputes that are prone to occur, and achieve the goal of being conducive to disease recovery, promoting insulin secretion, avoiding Effects of ketoacidosis

Inactive Publication Date: 2009-06-10
TIANJIN PACIFIC PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, it is known that diabetic patients have acute complications, urgently need to supplement energy and infusion medication, and when infusion of glucose solution is not suitable, medical disputes are prone to occur

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Add 25 mg of xylitol and Tween-807 g to 1000 ml of injection, add a small amount of activated carbon, heat and stir, press filter, filter the filtrate through a microporous membrane, make up the water for injection with the filtrate, mix well, potting, and sterilize to make injection liquid.

Embodiment 2

[0030] Add xylitol 500mg, Tween-8030g in every 1000 milliliters of injections, and the balance is sodium chloride isotonic solution. Add a small amount of activated carbon, heat and stir, press filter, filter the filtrate through a microporous membrane, supplement the filtrate with water for injection, mix well, potting, and sterilize to make an injection.

Embodiment 3

[0032] Add 150 mg of xylitol and 10 g of Tween-80 to every 1000 ml of injection, and the remainder is isotonic potassium chloride solution. Add a small amount of activated carbon, heat and stir, press filter, filter the filtrate through a microporous membrane, supplement the filtrate with water for injection, mix well, potting, and sterilize to make an injection.

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PUM

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Abstract

The invention relates to a xylitol intravenous fluid and preparing method thereof. The intravenous fluid contains xylitol 25mg-500mg, tween-80 7-30g, the rest is water for injection or isosmotic solution in per 1000 ml intravenous fluid. The metabolism in vivo of xylitol intravenous fluid provided by the invention is independent of the insulin, the sweet taste and the producing heat of the xylitol intravenous fiuld are similar to the glucose, so that the xylitol intravenous fluid can be used as a substitute of sugar for the diabetic. Moreover, the xylitol intravenous fluid can inhibit the ketoplasia and reduce the generation of blood plasma fatty acid, can be used for diabetes and ketone poisoning during surgery anaesthesia.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a xylitol intravenous injection and a preparation method thereof. Background technique [0002] Diabetes mellitus is a syndrome of glucose, protein and lipid metabolism disorders caused by insufficient insulin or defects in insulin cell metabolism. It is characterized by abnormally elevated concentrations of glucose in the bloodstream and glucose in the urine. When blood sugar is too high, typical symptoms of three excesses and one deficiency may appear, namely: polydipsia, polyuria, polyphagia, and weight loss, accompanied by fatigue and weakness. In severe cases, ketoacidosis and hyperosmolar coma may occur, and it is easy to be combined with multiple infections. With the prolongation of the course of the disease, its metabolic disorder can lead to chronic complications in tissues and organs such as eyes, kidneys, nerves, blood vessels and heart. Diabetes i...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/10A61K47/34A61K31/047A61P3/10
Inventor 宋德成
Owner TIANJIN PACIFIC PHARMA
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