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Doped bone repairing material and preparation method thereof

A bone repair and powder technology, applied in medical science, prosthesis, etc., can solve the problems of unfavorable new bone induction and generation, slow degradation of CPP, dense crystal structure, etc., achieve good degradation controllability, improve degradation performance, Effect of improving degradation performance

Inactive Publication Date: 2009-06-03
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, as an ideal bone repair material, it is a difficult point in this field to induce new bone growth and degrade with its rate to achieve complete recovery of autogenous bone, and the degradation products are non-toxic and harmless to the internal environment.
Most of the widely studied bioceramic bone repair materials nowadays degrade slowly due to their dense crystal structure and large molecular weight, which is extremely unfavorable for the induction and generation of new bone at the repair site. CPP also has this weakness.
Preliminary animal and clinical experiments of the inventor's research group have proved that CPP degrades slowly at the human implantation site

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] ①Calcium dihydrogen phosphate and potassium dihydrogen phosphate are mixed according to the ratio of calcium polyphosphate body and potassium polyphosphate in the doped bone repair material at a ratio of 9.5:0.5, and then calcined at about 450°C for about 15 hours to make Calcium dihydrogen phosphate and potassium dihydrogen phosphate are polymerized to prepare calcium polyphosphate and potassium polyphosphate;

[0031] ②Quickly cool and quench the high-temperature mixed burning material composed of calcium polyphosphate and potassium polyphosphate with crushed ice, dry the quenched calcium polyphosphate and potassium polyphosphate mixture with ethanol, and sieve it with a 200-mesh sieve after grinding. Put the sieved powder into the mold to apply a pressure of 1.0MPa, and keep the pressure for about 5 minutes to prepare the parison of the doped bone repair material;

[0032] ③ The blank is sintered at about 900°C for about 2 hours. After sintering, it is naturally cool...

Embodiment 2

[0034] ①Calcium dihydrogen phosphate and sodium dihydrogen phosphate were calcined at about 630°C for about 6 hours, so that calcium dihydrogen phosphate and sodium dihydrogen phosphate were polymerized to prepare calcium polyphosphate and sodium polyphosphate;

[0035] ②Quickly cool and quench calcium polyphosphate and sodium polyphosphate high-temperature burning materials with ice water respectively, dry calcium polyphosphate and sodium polyphosphate after quenching with ethanol respectively, and sieve with 200-mesh sub-sieve after grinding. The final powder is mixed according to the ratio of calcium polyphosphate body and sodium polyphosphate in the doped bone repair material at a ratio of 9.9:0.1, and the evenly mixed powder is put into the mold to apply a pressure of 0.9MPa, and hold the pressure for about 10 minutes , to prepare a parison of doped bone repair material;

[0036] ③ The blank is sintered at about 850°C for about 3 hours. After sintering, it is allowed to c...

Embodiment 3

[0038] ①Calcium carbonate and potassium carbonate are mixed according to the ratio of calcium polyphosphate and potassium polycarbonate in the doped bone repair material at a ratio of 9.7:0.3, and then react with phosphoric acid 1.5 times their total weight at about 25°C, and add Stir the excess phosphoric acid continuously until the reaction solution is clear, seal it and let it stand for about 12 hours. Calcium carbonate and phosphoric acid react to form calcium dihydrogen phosphate, and potassium carbonate and phosphoric acid react to form potassium dihydrogen phosphate. The concentration of phosphoric acid is 16mol / L. After the reaction is over, use a rotary evaporator to remove the moisture and phosphoric acid in the reaction solution, and then use absolute ethanol to wash the mixture of calcium dihydrogen phosphate and potassium dihydrogen phosphate to further remove residual phosphoric acid, and rinse to the bottom of the filtrate. The pH value is about 7 or so. After ...

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Abstract

The invention provides a doped bone repairing material, comprising the following main ingredients according to weight proportion: 9 to 9.9 portions of calcium polyphosphate body and 0.1 to 1 portion of alkali polyphosphate. The preparation method thereof is as follows: calcium biphosphate and alkali dihydric phosphate are formed at first, then mixed according to the required preparation ratio of the calcium polyphosphate and the portion of alkali polyphosphate in the materials, and forged at high temperature to generate polyreaction; then the material forged at high temperature is quickly cooled and quenched; then the forged material is converted into amorphous calcium polyphosphate and the alkali polyphosphate; then the amorphous calcium polyphosphate and the alkali polyphosphate are dried and ground into powder and then sintered at high temperature, thus manufacturing the crystallized doped bone repairing material. The doped bone repairing material provided by the invention has the characteristics of inorganic and organic characteristics, combination between doped element and calciumn element as well as combination of rigidity and toughness; moreover, the material also has excellent degrading controllable performances. The alkali metal ions released after degrading are innoxious to inner environments; and the inorganic irons can also promote the bone metabolizing, growing and nutrition absorption.

Description

1. Technical field [0001] The invention relates to the technical field of biomedical materials, in particular to the technical field of biomedical materials suitable for repairing human hard tissue defects. 2. Background technology [0002] In recent years, research on bone repair materials has focused on establishing ideal models that are non-toxic, harmless, and unchanged to the human body or implanted devices. The widely used artificial bone materials, such as: hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), bioactive glass, bioactive bone cement, etc., can all be connected with human bone and exhibit certain biological characteristics. Capacitance. However, due to differences in biodegradation, osteoinduction, and bone transmission, there is still considerable controversy regarding the search for bone repair materials that adapt to the human physiological environment and have excellent performance. deBruijin et al. believe that the formation of bone-like apatite l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/14A61L27/12
Inventor 万昌秀宋巍余喜讯张小华王践云田猛陈峰李华
Owner SICHUAN UNIV
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