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Chinese medicine granule containing sophora root extract and preparation method thereof

A technology of traditional Chinese medicine granules and extracts, which is applied in the directions of medical formulations containing active ingredients, pharmaceutical formulations, and medical formulations with non-active ingredients, etc., can solve the problems of unsightly appearance, poor taste, and low drug loading in granules.

Inactive Publication Date: 2009-05-27
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several common granule preparation processes and their existing defects: 1. Traditional granule preparation process, due to the high viscosity of traditional Chinese medicine extracts, most of the traditional granule preparation methods have low drug loading, unsightly appearance, and poor taste , easy to absorb moisture and other problems
5. In the field of preparations, there are also fluidized bed bottom spraying or side spraying techniques to manufacture western medicine pellets or spherical granules, which are mostly used in the development of sustained release preparations. Therefore, the developed products generally have slow and controlled release characteristics, and do not have immediate release characteristics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The preparation of active ingredient of the present invention: get American ginseng 138g, flavescens 736g, salvia miltiorrhiza 230g, cassia twig 138g, mistletoe 437g, hawthorn 437g, licorice 184g; Min, acidic cation exchange resin on the percolation liquid, eluted with distilled water to pH6.8, alkalized with ammonia water (pH10), eluted with methanol at a concentration of 70%, concentrated and recovered methanol to form an extract; take salvia miltiorrhiza and American ginseng, add NaHCO 3 The solution (0.1%) is extracted, and ethanol is added for precipitation, so that the alcohol concentration of the alcohol precipitation solution reaches 50%, filtered, and the filtrate is concentrated and recovered into ethanol to form an extract; the remaining medicines are extracted with water, filtered, concentrated into an extract, mixed uniformly, and prepared into the present invention active ingredient.

[0054] Preparation of masterbatch: Take the mixture of dextrin and star...

Embodiment 2

[0057] The preparation of active ingredient of the present invention: get American ginseng 184g, flavescens 782g, salvia miltiorrhiza 230g, cassia twig 184g, mistletoe 299g, hawthorn 299g, licorice 322g; Min, acidic cation exchange resin on the percolation liquid, distilled water to elute to pH6.9, add ammonia (pH10.5) to alkalinize, and ethanol to elute with a concentration of 75%, concentrate and recover ethanol to form an extract; take Salvia miltiorrhiza and American ginseng, Add NaHCO 3 The solution (0.2%) is extracted, and ethanol is added for precipitation, so that the alcohol concentration of the alcohol precipitation solution reaches 55%, filtered, and the filtrate is concentrated and recovered into ethanol to form an extract; the remaining medicines are extracted with water, filtered, concentrated into an extract, mixed uniformly, and prepared into the present invention. active ingredient.

[0058]Preparation of masterbatch: Take a mixture of micropowder silica gel ...

Embodiment 3

[0061] The preparation of active ingredient of the present invention: get: American ginseng 100g, flavescens 667.5g, salvia miltiorrhiza 200g, cassia twig 200g, mistletoe 532.5g, hawthorn 400g, licorice 200g; 3ml / min, acidic cation exchange resin on the percolation liquid, distilled water elution to pH7.0, adding ammonia (pH11) to alkalinize, propanol elution, concentration is 80%, concentrated recovery methanol becomes extract; American ginseng, with NaHCO 3 The solution (0.3%) is extracted, and ethanol is added for precipitation, so that the alcohol concentration of the alcohol precipitation solution reaches 60%, filtered, and the filtrate is concentrated and recovered to ethanol to form an extract; the remaining medicines are extracted with water, filtered, concentrated into an extract, mixed uniformly, and prepared into the present invention. active ingredient.

[0062] Preparation of masterbatch: take a mixture of dextrin and starch with a weight ratio of 1:1 and pass th...

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Abstract

The invention provides a traditional Chinese medicine granular preparation with shrubby sophora extract and a preparation method thereof. Traditional Chinese medicine spheroidized particles are prepared by using a traditional Chinese medicine extract and a pharmaceutically acceptable carrier. The shapes of the traditional Chinese medicine spheroidized particles are spherical or similar to spheres, and the density of the traditional Chinese medicine spheroidized particles ranges from 0.6 g / ml to 1.3 g / ml. A single dose of the spheroidized particles is small, the medicine taking is convenient, and the granular preparation can be used as a semifinished product of capsules and can also be used for developing sustained and controlled release preparations of traditional Chinese medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine granule containing Sophora flavescens extract and a preparation method thereof. Background technique [0002] Viral myocarditis (VMC) is myocardial cell degeneration and myocardial interstitial changes caused by viruses invading the myocardium, especially in children. According to related data reports: the incidence of the disease is increasing day by day, second only to coronary heart disease, rheumatic heart disease, etc., and most of the patients are young and middle-aged, which has seriously affected people's lives. [0003] Almost all kinds of viruses can cause viral myocarditis, among which coxsackie, influenza, echo, polio, mumps, and adenovirus are the main ones, especially coxsackie group B myocarditis is the most common. Numerous clinical data suggest that viral myocarditis can be transformed i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61K9/16A61K36/734A61K47/04A61K47/36A61K47/38A61K47/40A61P9/00A61P31/12
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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