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Antivirus transdermal emulsifiable paste containing penciclovir, liquorice, astragalus, cassia nomame and basil

A technology of penciclovir and transdermal cream, which is applied in the field of drugs for the treatment of herpes, and can solve the problem that the product cannot enter the body through the skin

Inactive Publication Date: 2011-09-14
谭国梁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] What can this explain? This means that its products may not be able to penetrate the skin and enter the body at all? Although the drug is marked with 1% penciclovir, there should be doubts about how much penciclovir penetrates into the skin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 0.5g of penciclovir, 1g of water-soluble azone, 1.0g of menthol, 0.5g of carbomer 941, add water to 100g, stir well, and form a white cream, called penciclovir antiviral transdermal cream number 1.

[0028] The penciclovir is a solution of 2 g of penciclovir dissolved in 98 g of 0.8% NaOH solution.

[0029] Apply this product on normal skin and eczema lesions, and it will be completely absorbed within 30 minutes without any trace, feeling comfortable, and no abnormal reaction; apply this product again in situ, the result is the same.

Embodiment 2

[0031] 1.0g penciclovir, 2g water-soluble azone, 2.0g menthol, 1.0g carbomer 941, add water to 100g, fully mix well, and form a white cream, called penciclovir antiviral transdermal milk Cream No. 2. The penciclovir is a solution of 2 g of penciclovir dissolved in 98 g of 0.8% NaOH solution.

[0032] Apply this ointment to the skin, no irritation is seen, and it is completely absorbed within 30 minutes without leaving any traces. This is a Jialiang transdermal formulation.

Embodiment 3

[0034] 0.5g penciclovir, 1.0g oleic acid, 30g saponin extract, 1.0g oil-soluble azone, 1.0g water-soluble azone, 1.0g menthol, 0.5g carbomer 941, add water to 100g, fully mixed evenly, into an orange-yellow cream. It is called Penciclovir Glycyrrhizae Antiviral Transdermal Cream No. 1.

[0035] Oleic acid can also be substituted with oils of sesame, eucalyptus, clove, cardamom, sweetgum, or litsea cubeba with essentially the same effect.

[0036] The penciclovir is a solution of 2 g of penciclovir dissolved in 98 g of 0.8% NaOH solution.

[0037] This cream is applied to the skin without irritation and is completely absorbed within 30 minutes without leaving traces. This is an ideal transdermal formulation.

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PUM

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Abstract

The invention relates to a penciclovir ganhuang soap antiviral transdermal cream. The cream is characterized in that a formulation comprises the following compositions in mixture ratio (weight portion): 0.5 to 1.0 portion of penciclovir, 1 to 2 portions of novel water-soluble azone and 1 to 2 portions of menthol. The penciclovir is western antiviral medicine and is compatible with the water-soluble azone and other strong cosolvents and transdermal agents in order to be favorable for the penciclovir in a junction phase among an oil phase, a water phase and a mixed phase; and at least the creamincreases solubility in five phases and achieves the treatment function through permeating epidermis, corium, subcutis, nerve ending and nerve fiber tissue of skin. Chinese and western medicines permeate each layer and subcutis of the skin through multiphase dissolution, multiphase permeation and high concentration, thereby implementing the functions of inhibiting and killing virus and adjusting immunity.

Description

technical field [0001] The invention belongs to a medicine for treating herpes, and in particular relates to penciclovir ganhuangzaoluo antiviral transdermal cream. Background technique [0002] Herpes virus infection is a frequently-occurring disease, especially herpes simplex virus-infected venereal herpes caused by sexual contact. There are two subtypes of the virus, HSV-1 and HSV-2, which cause clinical symptoms, because of the diversification of sexual behavior, common are: male and female genitals (including urethra, vagina, cervix), anus, lips and mouth with herpes and Pain, or any part of the body that is in contact with the genitals, lips and mouth may have symptoms of rash and pain, and repeated attacks are difficult to cure. [0003] Among the anti-herpes virus drugs, acyclovir and its derivatives or analogues have short-term definite curative effect and are widely used. However, in the National Center for Adverse Drug Reaction Monitoring, among the 928 reports ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/522A61K47/44
Inventor 谭国梁
Owner 谭国梁
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