Biguanide-containing liposomes

A technology of liposomes and phospholipids, applied in liposome delivery, medical preparations containing active ingredients, organic active ingredients, etc., can solve skin surface damage, affect polyhexanide release, affect polyhexanide resistance Microbial activity and other issues

Inactive Publication Date: 2009-04-15
LOHMANN & RAUSCHER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the problem is: poor stability of silver nitrate solution, possible absorption of silver ions, and destruction of skin surface due to protein coagulation caused by silver
[0018] However, the disadvantage of using polyhexanide solutions is that these antimicrobials lose their activity in the presence of even small amounts of negatively charged ions, such as alginate, acrylate, lactate or iodide ions. fact
This affects the polyhexanide release from the wound dressing and ultimately also affects the antimicrobial activity of the polyhexanide

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0084] To prepare the collagen sponge with antibacterial effect, 1% collagen suspension (derived from bovine) was thoroughly mixed with a defined amount of liposome suspension (in Tris buffer) and then placed in a plastic dish. The mixture was then flash-frozen at -50°C and subsequently lyophilized. Thus, collagen sponges having a polyhexanide content of 0.05 wt%, 0.1 wt%, 0.5 wt% or 1 wt% relative to the dry weight of the collagen were prepared.

[0085] Three different liposome suspensions were used:

[0086] I. Liposomes of E80-S, Cholesterol and Vitamin E (Suspension #20);

[0087] II. E80-S and vitamin E (suspension #21); and

[0088] III. Liposomes of DMPC and Cholesterol (Suspension #22).

[0089] Collagen sponges comprising liposomes containing polyhexanide and the liposome suspensions used to prepare these collagen sponges were examined in more detail for their resistance to Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans by agar diffusion assay....

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Abstract

The present invention relates to biguanide-containing liposomes and antiseptic preparations based on biguanide-containing liposomes, where the liposomes are characterized in that they are essentially free from lipids with anionic head groups, to the preparation of the biguanide-containing liposomes and of the antiseptic preparations, and to their possible uses and to the products arising from their use, in particular wound coverings.

Description

technical field [0001] The present invention relates to liposomes comprising biguanides, antibacterial formulations based on liposomes comprising at least one biguanide as microbicidally active agent, the preparation of said liposomes comprising biguanides and antibacterial formulations, their possible uses and Products that utilize their purpose. Background technique [0002] The wound healing process will be significantly worsened if the wound is dehydrated, if there is a large amount of bacteria present in the wound, and / or if the wound is treated with a toxic agent. By comparison, a moist environment, lack of pathogen colonization, and increased presence of growth factors will promote epithelialization and granulation tissue formation. The advantages of moist wound healing are unquestionable among experts, wherein the moist environment in the wound is intended to stimulate cell growth and thus achieve the fastest possible regeneration of damaged tissue. On the other ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61P31/02A61K31/155
CPCA61K9/0014A61K9/1277A61K9/127A61K31/155A61P17/00A61P31/00A61P31/02
Inventor 克里斯琴·勒雷尔蒂姆·阿克塞尔·威廉斯安德烈亚斯·瓦格纳
Owner LOHMANN & RAUSCHER
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