Panaxatriol saponin composition and uses in preparing medicament for immunity enhancement

Abstract

The invention relates to a panaxatriol saponin composition, wherein active components with immune-enhancing function in the composition mainly comprise ginsenoside-Re, ginsenoside-Rg1, ginsenoside-Rg2 and ginsenoside-Rh1, and the components in percentage by weight are: 25 to 50 percent of the ginsenoside-Re, 15 to 50 percent of the ginsenoside-Rg1, 0 to 30 percent of the ginsenoside-Rg2, and 0 to30 percent of the ginsenoside-Rh1. The panaxatriol saponin composition of the proportions has the immune-enhancing activity far larger than that of a ginseng monomer saponin, improves the curative effect of the immune-enhancing function, and reduces the toxic side effects. In addition, the preparation method is simple, and the production cost is low.

Description

technical field [0001] The invention relates to a traditional Chinese medicine and its application, in particular to a pharmaceutical composition with panaxatriol group saponin as an active ingredient and its application in preparing immune-enhancing medicine. Background technique [0002] Various diseases are associated with low immune function, such as tumors, AIDS and senile diseases. Therefore, it is of great significance to find drugs for enhancing immunity. Ginseng has a history of more than 4,000 years of application. Modern studies have shown that ginsenosides are the main active ingredients in ginseng, and have various pharmacological effects such as improving immune function. In the early stage, we studied the structure-activity relationship of ginsenosides in cellular and humoral immunity enhancement, and found that protopanaxatriol-type saponins have strong immune enhancement effects (1. Yu JL, Dou DQ, Chen XH, YangHZ, Guo N, Cheng GF. Immunoenhancing activity ...

AI Technical Summary

Problems solved by technology

However, in the actual clinical application of chemotherapy and radiotherapy adjuvant therapy, ginsenoside monomers used alone have relatively large toxic and side effects, such as ginsenoside-Rg 3 Shenyi Capsule is the main ingredient. In actual use, some patients may experience dry mouth and throat and oral ulcers after taking the medicine. If overdose, side effects such as sore throat, dizziness, tinnitus, nosebleed, chest tightness, and dreaminess may occur.

At the same time, the preparation process of monomeric saponins is relatively complicated, which increases the production cost and the treatment cost of patients.

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