Application of scopoletin in preparing medicament for treating or preventing tumour

Abstract

The invention relates to application of scopoletin in the preparation of a drug for preventing and treating tumor, wherein the drug for preventing and treating the tumor is a nuclear transcription factor-kB inhibitor. The invention also provides a pharmaceutical composition for treating or preventing the tumor, which contains effective amount of curative scopoletin and a medicinal carrier, or drugs for treating or preventing the tumor. The nuclear transcription factor-kB inhibitor is an effective monomer component of natural Chinese medicine, which has small toxic side effect, high safety, and specific function target point, and can be used for preparing medicaments of the nuclear transcription factor-kB inhibitor or antitumor medicaments.

Description

technical field [0001] The invention relates to the application of an antitumor drug, in particular to the application of scopolamine in the preparation of a drug for treating or preventing tumors. Background technique [0002] Colon cancer is a malignant tumor with high morbidity and mortality. The drug resistance of colon cancer is one of the main reasons affecting the efficacy and prognosis of chemotherapy. In order to overcome tumor drug resistance, people have conducted a lot of research on the mechanism of tumor drug resistance for many years. It has been confirmed that a variety of tumor tissues have high expression of NF-κB, and various anticancer drugs can activate NF-κB, and tumor cells with high expression of NF-κB show resistance to apoptosis mediated by chemotherapy and radiation . At present, a large number of studies have shown that NF-κB plays an important role in inflammation, immune response, tumor and so on. [0003] In most cells, heterodimeric NF-κB e...

AI Technical Summary

Problems solved by technology

As far as the research on NF-KB activation inhibitors is concerned, there are still many technical difficulties in directly transferring the mutant IκBα gene into tumor patients; antisense oligonucleotide therapy may lead to some important gene functions in the body. loss of loss; under normal circumstances, since proteasome and calpain are important regulators of cell cycle and cell function, there are still great problems in the clinical application of their inhibitors; and decoy oligonucleotides are still very problematic in terms of technology and economy. It is difficult to be widely used clinically

Therefore, it is difficult to apply the above NF-κB activation inhibitors in combination with chemotherapy drugs to reverse tumor drug resistance and chemotherapy sensitization

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